Md Saidur Rahman, Khandkar Shaharina Hossain, Sharnali Das, Sushmita Kundu et al.
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose levels; insulin acts via an anabolic pathway, while glucagon performs catabolic functions. Insulin regulates glucose le...
Patricio López‐Jaramillo, Diego Gómez-Arbeláez, Daniel Martínez-Bello, Marc Evans M. Abat et al.
BackgroundThe triglyceride glucose (TyG) index is an easily accessible surrogate marker of insulin resistance, an important pathway in the development of type 2 diabetes and cardiovascular diseases. However, the association of the TyG index with cardiovascular diseases and mortality has mainly been ...
Saruar Alam, Md. Kamrul Hasan, Sharif Neaz, Nazmul Hussain et al.
Diabetes mellitus has become a serious and chronic metabolic disorder that results from a complex interaction of genetic and environmental factors, principally characterized by hyperglycemia, polyuria, and polyphagia. Uncontrolled high blood sugar can result in a host of diabetic complications. Prol...
Intza Garin, Emma L. Edghill, İldem Akerman, Oscar Rubio‐Cabezas et al.
Heterozygous coding mutations in the INS gene that encodes preproinsulin were recently shown to be an important cause of permanent neonatal diabetes. These dominantly acting mutations prevent normal folding of proinsulin, which leads to beta-cell death through endoplasmic reticulum stress and apopto...
Biazid Alam Shibib, Laazina Khan, R Rahman
Coccinia indica leaves were extracted with 60% ethanol, solvents were evaporated and the residue was suspended in water. This suspension was administered orally at a dose of 200 mg/kg body wt. after 18 h of fasting to normal fed and streptozotocin-induced male diabetic rats (180-250 g). After 90 min...
Siddhartha Dutta, Rima Shah, Shubha Singhal, Sudeshna Banerjee Dutta et al.
Metformin has been designated as one of the most crucial first-line therapeutic agents in the management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent, metformin also has a plethora of pleiotropic effects on various systems and processes. It acts majorly by activating AMPK ...
Muhamad Noor Alfarizal Kamarudin, Md. Moklesur Rahman Sarker, Jin‐Rong Zhou, Ishwar S. Parhar
Growing evidence showed the increased prevalence of cancer incidents, particularly colorectal cancer, among type 2 diabetic mellitus patients. Antidiabetic medications such as, insulin, sulfonylureas, dipeptyl peptidase (DPP) 4 inhibitors and glucose-dependent insulinotropic peptide (GLP-1) analogue...
Akhtar Hussain, Muhammad Abdur Rahim, Abul Kalam Azad Khan, S Ali et al.
AIMS: To describe differences in prevalence of Type 2 diabetes mellitus with its associated risk factors between rural and urban populations in Bangladesh. Diagnostic criteria [fasting blood glucose (FBG) and oral glucose tolerance tests (OGTT)] were compared and reviewed for both populations. METHO...
Pamela J. Goodwin, Wendy R. Parulekar, Karen A. Gelmon, Lois E. Shepherd et al.
BACKGROUND: Metformin may improve metabolic factors (insulin, glucose, leptin, highly sensitive C-reactive protein [hs-CRP]) associated with poor breast cancer outcomes. The NCIC Clinical Trials Group (NCIC CTG) MA.32 investigates effects of metformin vs placebo on invasive disease-free survival and...
Abu Sadat Md. Sayem, Aditya Arya, Hamed Karimian, Narendiran Krishnasamy et al.
Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise pr...
M Abu Sayeed, Hajera Mahtab, Parvin Akter Khanam, Zafar Latif et al.
OBJECTIVE: To determine the prevalence of type 2 diabetes and impaired fasting glycemia (IFG) in a rural population of Bangladesh. RESEARCH DESIGN AND METHODS: A cluster sampling of 4,923 subjects >/=20 years old in a rural community were investigated. Fasting plasma glucose, blood pressure, height,...
Brian D. Green, Peter R. Flatt
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are physiological gut peptides with insulin-releasing and extrapancreatic glucoregulatory actions. Incretin analogues/mimetics activate GLP-1 or GIP receptors whilst avoiding physiological in...
S. K. Goel, Ravinder Pal Singh, Varinder Singh, Harmanjit Singh et al.
Metformin is a plant-based drug belonging to the class of biguanides and is known to treat type-2 diabetes mellitus (T2DM). The drug, combined with controlling blood glucose levels, improves the body's response to insulin. In addition, trials have identified the cardioprotective potential of metform...
Ding Ye, Miao Zhang, Wencheng Zhang, Qiulun Lu et al.
RATIONALE: AMP-activated protein kinase (AMPK) has been reported to play a protective role in atherosclerosis. However, whether AMPKα2 controls atherosclerotic plaque stability remains unknown. OBJECTIVE: The aim of this study was to evaluate the impact of AMPKα2 deletion on atherosclerotic plaque s...
Biny K. Joseph, Hsing‐Yin Liu, Jamie Francisco, Devanshi Pandya et al.
AMP kinase is a heterotrimeric serine/threonine protein kinase that regulates a number of metabolic processes, including lipid biosynthesis and metabolism. AMP kinase activity is regulated by phosphorylation, and the kinases involved have been uncovered. The particular phosphatases counteracting the...