Oscar Lindblad, Eugenia Cordero, Alexandre Puissant, L Macaulay et al.
Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of FLT3 inhibitor resistance, we generated two resistant AML cell lines by sustained treatment with the F...
Melanie J. Percy, Mary Frances McMullin, Simon N. Jowitt, Michael F. Potter et al.
The Chuvash form of polycythemia is an autosomal recessive disorder common to a large number of families in central Russia. Affected individuals have been reported to be homozygous for an Arg200Trp mutation in the von Hippel-Lindau (VHL) gene. We have screened 78 patients with erythrocytosis and fou...
Ian N Bruce, A. L. Bell
Recently, two new systems have been proposed for the nomenclature of primary vasculitides: the 1990 American College of Rheumatology (ACR) classification criteria and the 1992 Chapel Hill Consensus Conference (CHCC) definitions. We compared these two systems in the same cohort of patients with prima...
Thamal Darshana, David C. Rees, Anuja Premawardhena
BACKGROUND: Hydroxyurea and blood transfusion therapies remain the main therapeutic strategies for Sickle cell disease. Preliminary data suggest substantial variation and inconsistencies in practice of these two therapeutic modalities in South Asia. In this systematic review we searched Medline, Coc...
Mor Gross, Nathalie Ben‐Califa, Mary Frances McMullin, Melanie J. Percy et al.
Primary familial and congenital polycythaemia (PFCP) is a disease characterized by increased red blood cell mass, and can be associated with mutations in the intracellular region of the erythropoietin (EPO) receptor (EPOR). Here we explore the mechanisms by which EPOR mutations induce PFCP, using an...
Junlong Li, Xiao Zhang, Chunxia Qin, Xun Sun et al.
Purpose This study aimed to assess prognosis of patients with newly diagnosed multiple myeloma (NDMM) by combining [ 18 F]-FDG positron emission tomography (PET)/CT parameters and clinical indices. Methods Clinical data and PET/CT parameters of 133 NDMM patients were retrospectively analyzed for ass...
Mohammed Nadimul Islam, Akhil Ranjon Biswas, Humayra Nazneen, Nobendu Chowdhury et al.
BACKGROUND: Hemophilia is one of the commonest inherited bleeding disorders which may lead to chronic bleeding tendencies and life-long disabilities if not properly managed. Knowing the pattern of the disease aids in the prevention of disability and improvement of quality of life in hemophilia. Howe...
M A Uddin, MJ Rahman, MM Rahman, SA Sultana et al.
A prospective study was carried out on the patients presenting with history of recurrent joint swelling and wound bleeding in outpatient department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Armed Forces Institute of Pathology (AFIP), Dhaka Cantonment from January 2000 t...
Md. Abdul Mottalib, Tanvira Afroze Sultana, Md. Ibrahim Khalil, Siew Hua Gan et al.
BACKGROUND: Here, we report the phase distribution of chronic myeloid leukemia (CML), defined based on the World Health Organization criteria, among 63 patients in Bangladesh. All patients were diagnosed based on complete blood count, bone marrow examination including bone marrow aspiration and reve...
Miloš Kuzmanović, Nataša Tos̆ić, Nataša Čolović, Teodora Karan-Djurašević et al.
Based on current findings, the presence of NPM1 mutations in acute myeloid leukemia (AML) patients is associated with an increased probability of complete remission (CR) and better overall survival (OS). We determined the incidence and prognostic relevance of NPM1 mutations, their association with F...
Waheed Sangrar, Jeffrey Mewburn, Sandra G. Vincent, John T. Fisher et al.
Background Fps/Fes is a cytoplasmic tyrosine kinase that is abundantly expressed in the myeloid, endothelial, epithelial, neuronal and platelet lineages. Genetic manipulation in mice has uncovered potential roles for this kinase in hematopoiesis, innate immunity, inflammation and angiogenesis. Objec...
Jie Wang, Yun Wu, Md. Nazim Uddin, Rong Chen et al.
Introduction: Essential thrombocytosis (ET) is a group of myeloproliferative neoplasms characterized by abnormal proliferation of platelet and megakaryocytes. Research on potential key genes and novel regulatory markers in essential thrombocythemia (ET) is still limited. Methods: Downloading array p...
Celeste Bento, Mary Frances McMullin, Melanie J. Percy, Holger Cario
Clinical characteristics Primary familial and congenital polycythemia (PFCP) is characterized by isolated erythrocytosis in an individual with a normal-sized spleen and absence of disorders causing secondary erythrocytosis. Clinical manifestations relate to the erythrocytosis and can include plethor...
Jun Li, Qi Han, Yanqing Huang, Yanhui Wei et al.
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with high mortality and poor outcome, especially for elderly/un fi t (age ≥ 60 years or un fi t patients who are ineligible to receive intensive chemotherapy) with adverse genetic and molecular abnormalities in the newly diagnosed ...
Caian L. Vinhaes, Rozana Teixeira, Jay A. S. Monteiro-Júnior, Rafael Tibúrcio et al.
Sickle cell anemia (SCA) is the most common inherited hemolytic anemia worldwide. Here, we performed an exploratory study to investigate the systemic oxidative stress in children and adolescents with SCA. Additionally, we evaluated the potential impact of hydroxyurea therapy on the status of oxidati...