Gary L. Darmstadt, M Mao-Qiang, Emil Chi, SK Saha et al.
UNLABELLED: Topical therapy to enhance skin barrier function may be a simple, low-cost, effective strategy to improve outcome of preterm infants with a developmentally compromised epidermal barrier, as lipid constituents of topical products may act as a mechanical barrier and augment synthesis of ba...
Gary L. Darmstadt, M Mao‐Qiang, Emil Chi, SK Saha et al.
Topical therapy to enhance skin barrier function may be a simple, low‐cost, effective strategy to improve outcome of preterm infants with a developmentally compromised epidermal barrier, as lipid constituents of topical products may act as a mechanical barrier and augment synthesis of barrier lipids...
Stephen P. Luby, Amal Halder, Tarique Md. Nurul Huda, Leanne Unicomb et al.
BACKGROUND: Standard public health interventions to improve hand hygiene in communities with high levels of child mortality encourage community residents to wash their hands with soap at five separate key times, a recommendation that would require mothers living in impoverished households to typical...
Aamer Imdad, Luke C. Mullany, Abdullah H Baqui, Shams El Arifeen et al.
BACKGROUND: There is an increased risk of serious neonatal infection arising through exposure of the umbilical cord to invasive pathogen in home and facility births where hygienic practices are difficult to achieve. The World Health Organization currently recommends 'dry cord care' because of insuff...
Gary L. Darmstadt, Samir K. Saha, ASM Nawshad Uddin Ahmed, MAK Azad Chowdhury et al.
Background Infections and complications of prematurity are main causes of neonatal mortality. Very low birthweight premature infants have compromised skin barrier function, and are at especially high risk for serious infections and mortality. Our aim was to ascertain whether topical application of e...
Shams El Arifeen, Luke C. Mullany, Rashed Shah, Ishtiaq Mannan et al.
Background Up to half of neonatal deaths in high mortality settings are due to infections, many of which can originate through the freshly cut umbilical cord stump. We aimed to assess the effectiveness of two cord-cleansing regimens with the promotion of dry cord care in the prevention of neonatal m...
Gary L. Darmstadt, Nadia Badrawi, Paul A. Law, Saifuddin Ahmed et al.
BACKGROUND: Because the therapeutic options for managing infections in neonates in developing countries are often limited, innovative approaches to preventing infections are needed. Topical therapy with skin barrier-enhancing products may be an effective strategy for improving neonatal outcomes, par...
Gary L. Darmstadt, Samir K. Saha, ASM Nawshad Uddin Ahmed, Saifuddin Ahmed et al.
OBJECTIVE: Skin barrier therapy during the neonatal period, when the skin barrier is most highly compromised and the risk of death is greatest, has been shown to have a number of potential benefits, including reduced risk of nosocomial sepsis. Topical application of emollients that augment skin barr...
Amal Halder, Carole Tronchet, Shamima Akhter, Abbas Bhuiya et al.
BACKGROUND: We analyzed data from the baseline assessment of a large intervention project to describe typical handwashing practices in rural Bangladesh, and compare measures of hand cleanliness with household characteristics. METHODS: We randomly selected 100 villages from 36 districts in rural Bang...
Gary L. Darmstadt, Rebecca E. Rosenberg, ASM Nawshad Uddin Ahmed, Saifuddin Ahmed et al.
The validity of three methods (last menstrual period [LPM], Ballard and Dubowitz scores) for assessment of gestational age for premature infants in a low-resource setting was assessed, using antenatal ultrasound as the gold standard. It was hypothesized that LMP and other methods would perform simil...
Gary L. Darmstadt, Samir K. Saha
Topical application of natural oils is practised routinely in many countries and may either improve skin barrier function and health or have detrimental cutaneous and systemic effects, depending on the composition of the oil. Little literature on the epidemiology, practice, and perceptions of tradit...
Gary L. Darmstadt, Samir K. Saha, ASM Nawshad Uddin Ahmed, M CHOWDHURY et al.
Nadine Seward, David Osrin, Leah Li, Anthony Costello et al.
BACKGROUND: Sepsis accounts for up to 15% of an estimated 3.3 million annual neonatal deaths globally. We used data collected from the control arms of three previously conducted cluster-randomised controlled trials in rural Bangladesh, India, and Nepal to examine the association between clean delive...
Gary L. Darmstadt, ASM Nawshad Uddin Ahmed, Samir K. Saha, M. A. K. Azad Chowdhury et al.
Objective The skin is a potential source for invasive infections in neonates from developing countries such as Bangladesh, where the level of environmental contamination is exceedingly high. A randomized controlled trial was conducted from 1998 to 2003 in the Special Care Nursery of a tertiary hospi...
Kavita Singh, Shane M. Khan, Liliana Carvajal–Aguirre, Paul Brodish et al.
BACKGROUND: Skin-to-skin contact (SSC) between mother and newborn offers numerous protective effects, however it is an intervention that has been under-utilized. Our objectives are to understand which newborns in Bangladesh and Nigeria receive SSC and whether SSC is associated with the early initiat...