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31+ results
Field: Neuroscience

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

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Md. Sahab Uddin, Anna Stachowiak, Abdullah Al Mamun, Nikolay Tzvetkov et al.

Journal: Frontiers in Aging NeuroscienceYear: 2018
Citations: 457

Alzheimer’s disease (AD) is the most common cause of progressive dementia in the elderly. It is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid β (Aβ), and neurofibrillary tangles (NFTs), composed of tau protein,...

Health SciencesMedicineEpidemiologyOpen Access
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Addressing the risk of maladaptation to climate change

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Alexandre Magnan, E. Lisa F. Schipper, Maxine Burkett, Sukaina Bharwani et al.

Journal: Wiley Interdisciplinary Reviews Climate ChangeYear: 2016Citations: 419

This paper reviews the current theoretical scholarship on maladaptation and provides some specific case studies—in the Maldives, Ethiopia, South Africa, and Bangladesh—to advance the field by offering an improved conceptual understanding and more practice‐oriented insights. It notably highlights fou...

Life SciencesAgricultural and Biological SciencesEcology, Evolution, Behavior and Systematics
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Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries

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Chuangshi Wang, Shrikant I. Bangdiwala, Sumathy Rangarajan, Scott A. Lear et al.

Journal: European Heart JournalYear: 2018Citations: 394

AIMS: To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events. METHODS AND RESULTS: We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time a...

Social SciencesPsychologyExperimental and Cognitive PsychologyOpen Access
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Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood–Brain Barrier Integrity

Verified

Ying Bai, Yuan Zhang, Bing Han, Li Yang et al.

Journal: Journal of NeuroscienceYear: 2017Citations: 381

Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, we show that the circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Accurate brain tumor detection using deep convolutional neural network

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Md. Saikat Islam Khan, Anichur Rahman, Tanoy Debnath, Md. Razaul Karim et al.

Journal: Computational and Structural Biotechnology JournalYear: 2022Citations: 380

Detection and Classification of a brain tumor is an important step to better understanding its mechanism. Magnetic Reasoning Imaging (MRI) is an experimental medical imaging technique that helps the radiologist find the tumor region. However, it is a time taking process and requires expertise to tes...

Life SciencesNeuroscienceNeurologyOpen Access
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The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

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Sabine Ring, Sascha W. Weyer, Susanne B. Kilian, Elaine Waldron et al.

Journal: Journal of NeuroscienceYear: 2007Citations: 378

It is well established that the proteolytic processing of the beta-amyloid precursor protein (APP) generates beta-amyloid (Abeta), which plays a central role in the pathogenesis of Alzheimer's disease (AD). In contrast, the physiological role of APP and of its numerous proteolytic fragments and the ...

Health SciencesMedicinePhysiologyOpen Access
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Salinity Stress in Wheat (Triticum aestivum L.) in the Changing Climate: Adaptation and Management Strategies

Verified

Ayman El Sabagh, Mohammad Sohidul Islam, Milan Skalický, Muhammad Ali Raza et al.

Journal: Frontiers in AgronomyYear: 2021Citations: 362

Wheat constitutes pivotal position for ensuring food and nutritional security; however, rapidly rising soil and water salinity pose a serious threat to its production globally. Salinity stress negatively affects the growth and development of wheat leading to diminished grain yield and quality. Wheat...

Life SciencesAgricultural and Biological SciencesPlant ScienceOpen Access
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Mammalian Sirt1: insights on its biological functions

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Shahedur Rahman, Rezuanul Islam

Journal: Cell Communication and SignalingYear: 2011Citations: 355

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-ass...

Health SciencesMedicineGeriatrics and GerontologyOpen Access
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Progress in Brain Computer Interface: Challenges and Opportunities

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Simanto Saha, Khondaker A. Mamun, Khawza Ahmed, Raqibul Mostafa et al.

Journal: Frontiers in Systems NeuroscienceYear: 2021Citations: 353

Brain computer interfaces (BCI) provide a direct communication link between the brain and a computer or other external devices. They offer an extended degree of freedom either by strengthening or by substituting human peripheral working capacity and have potential applications in various fields such...

Life SciencesNeuroscienceCognitive NeuroscienceOpen Access
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Application of deep learning in detecting neurological disorders from magnetic resonance images: a survey on the detection of Alzheimer’s disease, Parkinson’s disease and schizophrenia

Verified

Manan Binth Taj Noor, Nusrat Zerin Zenia, M. Shamim Kaiser, Shamim Al Mamun et al.

Journal: Brain InformaticsYear: 2020Citations: 335

Neuroimaging, in particular magnetic resonance imaging (MRI), has been playing an important role in understanding brain functionalities and its disorders during the last couple of decades. These cutting-edge MRI scans, supported by high-performance computational tools and novel ML techniques, have o...

Life SciencesNeuroscienceNeurologyOpen Access
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Brain Tumor Detection Using Convolutional Neural Network

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Tonmoy Hossain, Fairuz Shadmani Shishir, Mohsena Ashraf, MD Abdullah Al Nasim et al.

Journal: 2019 1st International Conference on Advances in Science, Engineering and Robotics Technology (ICASERT)Year: 2019Citations: 312

Brain Tumor segmentation is one of the most crucial and arduous tasks in the terrain of medical image processing as a human-assisted manual classification can result in inaccurate prediction and diagnosis. Moreover, it is an aggravating task when there is a large amount of data present to be assiste...

Life SciencesNeuroscienceNeurology
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Ethylene-gibberellin signaling underlies adaptation of rice to periodic flooding

Verified

Takeshi Kuroha, Keisuke Nagai, Rico Gamuyao, Diane Wang et al.

Journal: ScienceYear: 2018Citations: 307

How rice defeats the floodwaters Deepwater rice varieties grow taller when flooded, in a growth response driven by the plant hormones gibberellin and ethylene. This keeps the leaves above the water. Kuroha et al. identified the genes underlying this phenotype, which encode a component of the gibbere...

Life SciencesAgricultural and Biological SciencesPlant ScienceOpen Access
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The Accidental Internationalists: A Theory of Born Globals

Verified

Jean‐François Hennart

Journal: Entrepreneurship Theory and PracticeYear: 2013Citations: 306

The distinguishing characteristic of international new ventures/born globals (INVs/BGs) is that they have foreign sales from the outset, or very quickly afterward. I argue that this is due to their business model. INVs/BGs sell to spatially dispersed customers distinctive niche products that incur l...

Social SciencesBusiness, Management and AccountingStrategy and Management
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Topologically Convergent and Divergent Structural Connectivity Patterns between Patients with Remitted Geriatric Depression and Amnestic Mild Cognitive Impairment

Verified

Feng Bai, Ni Shu, Yonggui Yuan, Yongmei Shi et al.

Journal: Journal of NeuroscienceYear: 2012Citations: 306

Alzheimer's disease (AD) can be conceptualized as a disconnection syndrome. Both remitted geriatric depression (RGD) and amnestic mild cognitive impairment (aMCI) are associated with a high risk for developing AD. However, little is known about the similarities and differences in the topological pat...

Life SciencesNeuroscienceCognitive NeuroscienceOpen Access
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The role of perceived usefulness, perceived ease of use, security and privacy, and customer attitude to engender customer adaptation in the context of electronic banking

Verified

Nadim Jahangir, Noorjahan Begum

Journal: AFRICAN JOURNAL OF BUSINESS MANAGEMENTYear: 2008Citations: 305

This research intends to propose a conceptual framework that will investigate the effects of perceived usefulness, ease of use, and security and privacy on customer adaptation mediated through customer attitude in the context of e-banking. To test the framework, structural equation modeling techniqu...

Social SciencesDecision SciencesInformation Systems and ManagementOpen Access
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