Andrew Mente, Martin O’Donnell, Sumathy Rangarajan, Matthew McQueen et al.
BACKGROUND WHO recommends that populations consume less than 2 g/day sodium as a preventive measure against cardiovascular disease, but this target has not been achieved in any country. This recommendation is primarily based on individual-level data from short-term trials of blood pressure (BP) with...
François Lamontagne, Marie-Hélène Masse, Julie Ménard, Sheila Sprague et al.
BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction. METHODS: In this randomized, placebo-controlled tri...
Muaz Rahman, Tamanna Howlader, Mohammad Shahed Masud, Mohammad Lutfor Rahman
BACKGROUND: Malnutrition in children under five years remains a significant problem in Bangladesh, despite substantial socio-economic progress and a decade of interventions aimed at improving it. Although several studies have been conducted to identify the important risk factors of malnutrition, non...
Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, Subhasish Das et al.
BACKGROUND: More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed development of their gut microbiota. METHOD...
Tahmeed Ahmed, Mohammad Ali, Mohammad Mofiz Ullah, Ireen A Choudhury et al.
Background Severely malnourished children have high mortality rates. Death commonly occurs during the first 48 h after hospital admission, and has been attributed to faulty case-management. We developed a standardised protocol for acute-phase treatment of children with severe malnutrition and diarrh...
Mirza Hasanuzzaman, M. H. M. Borhannuddin Bhuyan, Ali Raza, Barbara Hawrylak-Nowak et al.
Selenium (Se) is yet to be confirmed as essential for plants, but it has proven to be an essential trace element for humans and other animals. However, it is well documented that Se is a beneficial element for plants. Recent studies show that Se treatment at a low concentration exerts positive effec...
Tahera Akter, Fatema Tuz Jhohura, Fahmida Akter, Tridib Roy Chowdhury et al.
BACKGROUND: Public health is at risk due to chemical contaminants in drinking water which may have immediate health consequences. Drinking water sources are susceptible to pollutants depending on geological conditions and agricultural, industrial, and other man-made activities. Ensuring the safety o...
Abdullah H Baqui, Robert E. Black, Shams El Arifeen, Mohammad Yunus et al.
Abstract Objective: To evaluate the effect on morbidity and mortality of providing daily zinc for 14 days to children with diarrhoea. Design: Cluster randomised comparison. Setting: Matlab field site of International Center for Diarrhoeal Disease Research, Bangladesh. Participants: 8070 children age...
Robert E. Black, Kenneth H. Brown, Stan Becker, A. R. M. A. Alim et al.
Longitudinal studies were done in two villages rural Bangladesh to learn more about the interactions between infectious diseases and the nutritional status of children. Diarrheal diseases, identified by surveillance of 197 children aged 2-60 months, were studied for bacterial, viral and parasitic en...
Dinesh Mondal, Juliana Minak, Masud Alam, Yue Liu et al.
BACKGROUND: Malnourished children are at increased risk for death due to diarrhea. Our goal was to determine the contribution of specific enteric infections to malnutrition-associated diarrhea and to determine the role of enteric infections in the development of malnutrition. METHODS: Children from ...
Masahiro Hashizume, Ben Armstrong, Shakoor Hajat, Yukiko Wagatsuma et al.
BACKGROUND: We estimated the effects of rainfall and temperature on the number of non-cholera diarrhoea cases and identified population factors potentially affecting vulnerability to the effect of the climate factors in Dhaka, Bangladesh. METHODS: Weekly rainfall, temperature and number of hospital ...
Mohammad Nazmul Islam, Abdur Rauf, Fowzul Islam Fahad, Talha Bin Emran et al.
), are toxic or can create oxidative stress in cells, a response involved in the pathogenesis of numerous diseases depending on their concentration, location, and cellular conditions. Superoxide dismutase (SOD) activities as an endogenous and exogenous cell defense mechanism include the potential us...
Margaret Kosek, Tahmeed Ahmed, Zulfiqar A Bhutta, Laura E. Caulfield et al.
BACKGROUND: Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populati...
Benjamin F. Arnold, Clair Null, Stephen P. Luby, Leanne Unicomb et al.
INTRODUCTION: Enteric infections are common during the first years of life in low-income countries and contribute to growth faltering with long-term impairment of health and development. Water quality, sanitation, handwashing and nutritional interventions can independently reduce enteric infections ...
Karen L. Kotloff, Dilruba Nasrin, William C. Blackwelder, Yukun Wu et al.
BACKGROUND: Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income and middle-income countries. The Global Enteric Multicenter Study (GEMS) has described the incidence, aetiology, and sequelae of medically attended moderate-to-severe diarrhoe...