Martin J. Garland, Katarzyna Migalska, Tuan Mazlelaa Tuan Mahmood, Thakur Raghu Raj Singh et al.
In order to exploit the transdermal route for systemic delivery of a wide range of drug molecules, including peptide/protein molecules and genetic material, a means of disrupting the excellent barrier properties of the uppermost layer of the skin, the stratum corneum, must be sought. The use of micr...
Prateek Ranjan Yadav, Monika Nasrin Munni, Lauryn Campbell, Golam Mostofa et al.
The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the tr...
Ravinder Verma, Ajeet Kaushik, Rafa Almeer, Md. Habibur Rahman et al.
Purpose: The purpose of this proposed research was to investigate a nano-formulation developed using self-nanoemulsifying drug delivery system (SNEDDS) to improve the pharmacodynamic potential of rosuvastatin by assisting its transportation through lymphatic circulation. Methods: The utilized lipids...
Ronald Grigg, M. J. R. DORRITY, Frances Heaney, John F. Malone et al.
James Regun Karmoker, Ikramul Hasan, Nusrat Ahmed, Mohammad Saifuddin et al.
The grail of the study was to design, develop and characterize sustained release mucoadhesive microspheres of acyclovir and to optimize the drug release profile using response surface methodology by applying Box–Behnken design (BBD) which was equipped with three levels and three factors. Microsphere...
Ravi Sheshala, Gan Chew Hong, Wong Pui Yee, Venkata Srikanth Meka et al.
The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepare...
Vishal Bhardwaj, Nirmala, S.L. Harikumar
Oral controlled release delivery systems are programmed to deliver the drug in predictable time frame that will increase the efficacy and minimize the adverse effects and increase the bioavailability of drugs. It is most widely utilized route of administration among all the routes that have been exp...
Mohammad Hossain Shariare, Shakila Sharmin, Israt Jahan, Hasan Mahmud Reza et al.
Reza-ul Jalil
Poly(lactic acid) [PLA] and its co-polymers with glycolic acid [PLCG] have been known for the past 20 years of its biodegradability and histocompatibility. Their physico-chemical and biological properties have been found suitable, in many instances, for sustaining drug release in vivo and in vitro f...
Mohammad Hossain Shariare, Mohammad A. Altamimi, Akbar L. Marzan, Rahnuma Tabassum et al.
BACKGROUND: performance of furosemide nanosuspensions. METHODS: dissolution experiments were conducted to compare the representative formulation with raw drug powder. The bioavailability of nanosuspension was, also, evaluated in mice as an animal model. RESULTS: about 233% and 266%, respectively. Th...
Paul W. Armstrong, Ronald Grigg, Frances Heaney, Sivagnanasundram Surendrakumar et al.
Tanzina Sharmin Nipun, Sardar Mohammad Ashraful Islam
In the study, self emulsifying drug delivery system (SEDDS) of gliclazide, a poorly soluble drug, was developed and evaluated by in-vitro, ex-vivo and in-vivo techniques. Oil and surfactant were screened out according to their solubilizing capacity. Among the tested components Transcutol HP and Twee...
Mithun Saha, Diti Rani Saha, Tahamina Ulhosna, Shazid Md. Sharker et al.
The lower drug retention to the eye's anterior portion is a prime concern in the ocular drug delivery system. To improve the drug retention capacity, we aimed to develop drug–containing nanoparticles using Quality by Design (QbD) approach. The current study describes the development of resveratrol-l...
Shihab Uddin, Rafiqul Islam, Md. Raihan Chowdhury, Rie Wakabayashi et al.
Lipid-based biocompatible ionic liquids (LBILs) have attracted attention as carriers in transdermal drug delivery systems (TDDSs) because of their lipophilic character. In this study, we report the formulation of a peptide–LBIL complex microencapsulated in an oil phase as a potential carrier for the...
Rahul Dev Bairagi, Raiyan Rahman Reon, Md. Mahbub Hasan, Sumit Kanti Sarker et al.
Ocular drug delivery is a significant challenge due to the intricate anatomy of the eye and the various physiological barriers. Conventional therapeutic approaches, while effective to some extent, often fall short in effectively targeting ocular diseases, resulting in suboptimal therapeutic outcomes...