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16+ results
Field: Pharmacological Effects of Natural Compounds

Pharmacological potential of ginseng and its major component ginsenosides

Verified

Zubair Ahmed Ratan, Mohammad Faisal Haidere, Yo Han Hong, Sang Hee Park et al.

Journal: Journal of Ginseng Research
Year: 2020
Citations: 512

Ginseng has been used as a traditional herb in Asian countries for thousands of years. It contains a large number of active ingredients including steroidal saponins, protopanaxadiols, and protopanaxatriols, collectively known as ginsenosides. In the last few decades, the antioxidative and anticancer...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2

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Rajib Islam, Md. Rimon Parves, Archi Sundar Paul, Nizam Uddin et al.

Journal: Journal of Biomolecular Structure and DynamicsYear: 2020Citations: 347

value of 0.842 for the training set and 0.753 for the test set. Our proposed MLR model can predict the favorable binding energy compared with the binding energy detected from molecular docking. ADMET analysis demonstrates that these candidates appear to be safer inhibitors. Our comprehensive computa...

Physical SciencesComputer ScienceComputational Theory and MathematicsOpen Access
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Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Verified

Md. Abdul Hannan, Md. Ataur Rahman, Abdullah Al Mamun Sohag, Md Jamal Uddin et al.

Journal: NutrientsYear: 2021Citations: 313

L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquino...

Health SciencesMedicineComplementary and alternative medicineOpen Access
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Extracts and molecules from medicinal plants against herpes simplex viruses

Verified

Mahmud Tareq Hassan Khan, Arjumand Ather, Kenneth D. Thompson, Roberto Gambari

Journal: Antiviral ResearchYear: 2005Citations: 312

Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans, especially in the case of highly susceptible adults. Moreover, HSV-2 has been reported to be a high risk factor for HIV infection. Therefore, the discovery of novel anti-HSV drugs deserves great efforts. In this paper, we revi...

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacology
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Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra

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Md. Kamrul Hasan, Iffat Ara, Muhammad Shafiul Alam Mondal, Yearul Kabir

Journal: HeliyonYear: 2021Citations: 189

Linn. It is an herb-type plant with medicinal value. In the following article, we shall elaborately look at the plants' phytochemical constituents and the pharmacological impact of those substances. Several compounds such as glycyrrhizin, glycyrrhizinic acid, isoliquiritin, and glycyrrhizic acid hav...

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacologyOpen Access
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Anti-hypertensive Effect of Cereal Antioxidant Ferulic Acid and Its Mechanism of Action

Verified

Md Ashraful Alam

Journal: Frontiers in NutritionYear: 2019Citations: 173

Ferulic acid is a simple phenolic acid found mainly in cereals and grains, used as an antioxidant and food preservative. Recent evidence suggests that ferulic acid possess anti-inflammatory, anti-diabetic, anticancer, and cardioprotective properties. Several investigations also have shown that ferul...

Health SciencesMedicineBiochemistryOpen Access
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Hericium erinaceus: an edible mushroom with medicinal values

Verified

Md. Asaduzzaman Khan, Mousumi Tania, Rui Liu, Mohammad Mijanur Rahman

Journal: Journal of Complementary and Integrative MedicineYear: 2013Citations: 172

Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in...

Health SciencesMedicinePharmacology
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Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice

Verified

Yuqing Chen, Dan Liu, Dingyi Wang, Shanshan Lai et al.

Journal: Food and Chemical ToxicologyYear: 2019Citations: 156

GFP-N, a novel heteropolysaccharide with a molecular weight of 1.26 × 107 Da, was isolated from maitake mushroom and purified by anion-exchange chromatography on a DEAE cellulose-52 column and gel-filtration chromatography on a Sephadex G-100 column. Its structure was characterized by Fourier transf...

Health SciencesMedicinePharmacology
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Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities

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Muhammad Jahangir Hossen, Woo Seok Yang, Daewon Kim, Adithan Aravinthan et al.

Journal: Scientific ReportsYear: 2017Citations: 156

Abstract Thymoquinone (TQ) is a bioactive component of black seed ( Nigella sativa ) volatile oil and has been shown to have anti-oxidative, anti-inflammatory, and anti-cancer properties. In the present study, we explored the molecular mechanisms that underlie the anti-inflammatory effect of TQ and ...

Health SciencesMedicineComplementary and alternative medicineOpen Access
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Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

Verified

Muhammad Bin Sayeed, S.M.M. Karim, Tasnuva Sharmin, Mohammed Monzur Morshed

Journal: MedicinesYear: 2016Citations: 152

Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokine...

Health SciencesMedicineSurgeryOpen Access
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Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

Verified

Ibrahim Jantan, Md. Areeful Haque, Laiba Arshad, Hemavathy Harikrishnan et al.

Journal: The Journal of Nutritional BiochemistryYear: 2021Citations: 144

The high failure rate of the reductionist approach to discover effective and safe drugs to treat chronic inflammatory diseases has led scientists to seek alternative ways. Recently, targeting cell signaling pathways has been utilized as an innovative approach to discover drug leads from natural prod...

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacology
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Anti-inflammatory activity of seed essential oil from Zizyphus jujuba

Verified

Sharif M. Al‐Reza, Jung In Yoon, Hyo Jung Kim, Jong‐Sang Kim et al.

Journal: Food and Chemical ToxicologyYear: 2009Citations: 134

This study was undertaken to evaluate the effect of essential oil from seeds of Zizyphus jujuba on TPA-induced skin inflammation in experimental mice. Exposure of TPA on the ear of the BALB/c mice caused a marked increase in both ear thickness and skin water content. The ear thickness was measured f...

Life SciencesAgricultural and Biological SciencesFood Science
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An Insight Into the Modulatory Effects and Mechanisms of Action of Phyllanthus Species and Their Bioactive Metabolites on the Immune System

Verified

Ibrahim Jantan, Md. Areeful Haque, Menaga Ilangkovan, Laiba Arshad

Journal: Frontiers in PharmacologyYear: 2019Citations: 128

species should be carried out to provide sufficient data to prove that their traditional uses are inherently effective and safe and will allow clinical trials to be pursued for their further development as therapeutic agents to treat immune-related disorders.

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacologyOpen Access
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Adaptogenic effects of Panax ginseng on modulation of immune functions

Verified

Zubair Ahmed Ratan, Soo-Hyun Youn, Yi-Seong Kwak, Chang-Kyun Han et al.

Journal: Journal of Ginseng ResearchYear: 2020Citations: 126

Traditional medicinal practices have used natural products such as adaptogens to treat inflammatory, autoimmune, neurodegenerative, bacterial, and viral diseases since the early days of civilization. Panax ginseng Myer is a common herb used in East Asian countries for millennia, especially in Korea,...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Phyllanthus emblica: A comprehensive review of its therapeutic benefits

Verified

Bashir Ahmad, Nabia Hafeez, Abdur Rauf, Shumaila Bashir et al.

Journal: South African Journal of BotanyYear: 2021Citations: 116

Medicinal plants are precious gifts of nature, which may serve as a source of food and medicine to humans. Phyllanthus emblica L has held a unique position in the Indian (Ayurvedic), Turkish, Unani, and Tibetan medicinal systems for centuries. Its nutritional, therapeutic and healing potentials have...

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacologyOpen Access
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