Anna‐Lena Lindberg, Eva-Charlotte Ekström, Barbro Nermell, Mahfuzar Rahman et al.
Although genetic polymorphisms have been shown to explain some of the large variation observed in the metabolism of inorganic arsenic there may be several other factors playing an important role, e.g. nutrition. The objective of this study was to elucidate the influence of various factors on current...
Shoumen Lasker, Md Mizanur Rahman, Faisal Parvez, Mushfera Zamila et al.
The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following fou...
Joseph Butchart, Laura Brook, Vivienne Hopkins, Jessica L. Teeling et al.
OBJECTIVES: To determine whether the tumor necrosis factor α inhibitor etanercept is well tolerated and obtain preliminary data on its safety in Alzheimer disease dementia. METHODS: In a double-blind study, patients with mild to moderate Alzheimer disease dementia were randomized (1:1) to subcutaneo...
Krishna Palipudi, Prakash C. Gupta, Dhirendra Narain Sinha, Linda J. Andes et al.
BACKGROUND: Tobacco use has been identified as the single biggest cause of inequality in morbidity. The objective of this study is to examine the role of social determinants on current tobacco use in thirteen low-and-middle income countries. METHODOLOGY/PRINCIPAL FINDINGS: We used nationally represe...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Background Populations in South and East Asia and many other regions of the world are chronically exposed to arsenic-contaminated drinking water. To various degrees, ingested inorganic arsenic (InAs) is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via folate-dependent on...
Hannah Blencowe, Simon Cousens, Mary L. Kamb, Stuart M. Berman et al.
BACKGROUND: Globally syphilis is an important yet preventable cause of stillbirth, neonatal mortality and morbidity. OBJECTIVES: This review sought to estimate the effect of detection and treatment of active syphilis in pregnancy with at least 2.4 MU benzathine penicillin (or equivalent) on syphilis...
Maria Kippler, A.M. Waheedul Hoque, Rubhana Raqib, Helena Öhrvik et al.
Cadmium (Cd) is a widespread, highly toxic environmental pollutant known to accumulate in human placenta. The aim of the present study was to elucidate to what extent the accumulation of Cd in human placenta interacts with the transport of micronutrients to the fetus. Cd and micronutrients were meas...
Barbro Nermell, Anna‐Lena Lindberg, Mahfuzar Rahman, Marika Berglund et al.
This study aims at evaluating the suitability of adjusting urinary concentrations of arsenic, or any other urinary biomarker, for variations in urine dilution by creatinine and specific gravity in a malnourished population. We measured the concentrations of metabolites of inorganic arsenic, creatini...
Md. Sahab Uddin, Md. Tanvir Kabir, Abdullah Al Mamun, Mohamed M. Abdel‐Daim et al.
Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau protein. People carrying the APOE4 allele are at high risk of AD concerning the ones carrying the ε3 allele, while the ε2 ...
Lawrence D. Hayes, Martha White, Nigel Unwin, R. Bhopal et al.
BACKGROUND: Differences in level of physical activity between European, Indian, Pakistani and Bangladeshi populations living in the UK might contribute to differences in the prevalence of diabetes and cardiovascular disease risk markers that exist in these populations. METHODS: Type and level of phy...
Rubhana Raqib, Sultan Ahmed, Rokeya Sultana, Yukiko Wagatsuma et al.
Chronic exposure to arsenic, a potent carcinogen and toxicant, via drinking water is a worldwide public health problem. Because little is known about early-life effects of arsenic on immunity, we evaluated the impact of in utero exposure on infant immune parameters and morbidity in a pilot study. Pr...
Lucy Griffiths, Mario Cortina‐Borja, Francesco Sera, Theodora Pouliou et al.
OBJECTIVE: To describe levels of physical activity, sedentary time and adherence to Chief Medical Officers (CMO) physical activity guidelines among primary school-aged children across the UK using objective accelerometer-based measurements. DESIGN: Nationally representative prospective cohort study....
Faruque Parvez, Gail A. Wasserman, Pam Factor‐Litvak, Xinhua Liu et al.
BACKGROUND: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children's intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. METHODS: We investigated the associations...
Habibul Ahsan, Yu Chen, Muhammad G. Kibriya, Vesna Slavkovich et al.
We conducted a case-control study to investigate interindividual variability in susceptibility to health effects of inorganic arsenic due to arsenic metabolism efficiency, genetic factors, and their interaction. A total of 594 cases of arsenic-induced skin lesions and 1,041 controls was selected fro...
Maria Kippler, Karin Engström, Simona Jurković Mlakar, Matteo Bottai et al.
Dietary cadmium exposure was recently found to alter DNA methylation in adults, but data on effects early in life are lacking. Our objective was to evaluate associations between prenatal cadmium exposure, DNA methylation and birth weight. In total 127 mother-child pairs from rural Bangladesh were st...