Farazul Haque, Nitish Kumar Verma, Mohammad Alfatah, Swati Bijlani et al.
Sophorolipid induces ROS generation in <italic>C. albicans</italic> leading to mitochondrial dysfunction and ER stress followed by the release of Ca<sup>2+</sup> ions (from the ER lumen) that enter mitochondria and further magnify ROS generation leading to cell death.
Sultan Ahmed, Rubhana Raqib, Guðmundur H. Guðmundsson, Peter Bergman et al.
Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting a major threat to the public health. The currently recommended long term treatment regimen with multiple antibiotics is associated with poor patient compliance, which in turn, ...
Maria Deloria Knoll, Julia C. Bennett, Maria Garcia Quesada, E. Wangeci Kagucia et al.
Serotype-specific surveillance for invasive pneumococcal disease (IPD) is essential for assessing the impact of 10- and 13-valent pneumococcal conjugate vaccines (PCV10/13). The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project aimed to evaluate the global evidence to...
Madhu Emmadi, Naeem Khan, Lennart Lykke, Katrin Reppe et al.
Invasive pneumococcal diseases (IPDs) remain the leading cause of vaccine-preventable childhood death, even though highly effective pneumococcal conjugate vaccines (PCVs) are used in national immunization programs in many developing countries. Licensed PCVs currently cover only 13 of the over 90 ser...
Stephan Schwander, Martha Torres, Claudia Carranza C, Dante Escobedo et al.
Protective immunity against Mycobacterium tuberculosis requires CD4+ lymphocyte-mediated immune responses and IFN-gamma activity. As the primary portal of entry of M. tuberculosis is the lung, pulmonary immune responses against multiple M. tuberculosis Ags were compared between both M. tuberculosis-...
Nishant Jaiswal, Meenu Singh, Rashmi Ranjan Das, Ishita Jindal et al.
INTRODUCTION: Each SAARC nation falls in the zone of high incidence of pneumococcal disease but there is a paucity of literature estimating the burden of pneumococcal disease in this region. OBJECTIVE: To identify the prevalent serotypes causing invasive pneumococcal disease in children of SAARC cou...
N. R. Jena
Repurposed drugs are now considered as attractive therapeutics against COVID-19. It is shown that Remdesivir, a nucleoside drug that was originally invented for the Ebola virus, is effective in suppressing the replication of SARS-CoV-2 that causes COVID-19. Similarly, Galidesivir, Favipiravir, Ribav...
Giovanni Sotgiu, Simon Tiberi, Rosella Centis, Lia D’Ambrosio et al.
In spite of the recent introduction of two new drugs (delamanid and bedaquiline) and a few repurposed compounds to treat multidrug-resistant and extensively drug-resistant tuberculosis (MDR- and XDR-TB), clinicians are facing increasing problems in designing effective regimens in severe cases. Recen...
M S Flora, MN Amin, MR Karim, Shahana Afroz et al.
Despite success in tuberculosis control, multi-drug resistant tuberculosis in Bangladesh is increasing and currently multi-drug-resistant tuberculosis rate is 3.6% in new cases and 19% in re-treatment cases. This study focused on determination of multi-drug-resistant tuberculosis which is warranted ...
Khalequz Zaman, Mohammad Yunus, Shams El Arifeen, Abdullah H Baqui et al.
The objective of the study was to determine the prevalence of smear-positive tuberculosis (TB) in a rural area in Bangladesh at Matlab. A TB surveillance system was established among 106,000 people in rural Bangladesh at Matlab. Trained field workers interviewed all persons aged > or = 15 years to d...
S Koirala, Borisov Se, Edvardas Danila, Andrei Mariandyshev et al.
The World Health Organization (WHO) recommends countries introduce new anti-TB drugs in the treatment of multidrug-resistant tuberculosis. The aim of the study is to prospectively evaluate the effectiveness of bedaquiline (and/or delamanid)- containing regimens in a large cohort of consecutive TB pa...
Tord Holme, Motiur Rahman, Per‐Erik Jansson, Göran Widmalm
Moraxella catarrhalis has recently been shown to be both widespread and pathogenic, in contrast to previous reports. Several factors have been suggested as virulence factors, lipopolysaccharide (LPS) being one. Recent studies have shown the LPS to be without the O-chain, i.e. the polysaccharide part...
Kona Chowdhury, Rahnuma Ahmad, Susmita Sinha, Siddhartha Dutta et al.
Drug-resistant tuberculosis (DR-TB) has continued to be a global health cataclysm. It is an arduous condition to tackle but is curable with the proper choice of drug and adherence to the drug therapy. WHO has introduced newer drugs with all-oral shorter regimens, but the COVID-19 pandemic has disrup...
Arnaud Trébucq, Tom Decroo, Armand Van Deun, Alberto Piubello et al.
About ten years ago, the first results of the so-called "Bangladesh regimen", a short regimen lasting nine months instead of 20 months, revolutionized multidrug-resistant tuberculosis (MDR-TB) treatment. Similar short regimens were studied in different settings, relying for their efficacy on a later...
Paul Collini, Martin A. Bewley, M. Mohasin, Helen M. Marriott et al.
Abstract Rationale People living with HIV are at significantly increased risk of invasive pneumococcal disease, despite long-term antiretroviral therapy (ART). The mechanism explaining this observation remains undefined. Objectives To determine if apoptosis-associated microbicidal mechanisms, requir...