Saifon Chawanpaiboon, Joshua P. Vogel, Ann‐Beth Moller, Pisake Lumbiganon et al.
BACKGROUND: Preterm birth is the leading cause of death in children younger than 5 years worldwide. Although preterm survival rates have increased in high-income countries, preterm newborns still die because of a lack of adequate newborn care in many low-income and middle-income countries. We estima...
Neal Russell, Anna C. Seale, Megan O’Driscoll, Catherine O’Sullivan et al.
BACKGROUND: Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide. METHODS: We conducted systematic literature reviews (PubMed/Medline,...
Anna C. Seale, Fiorella Bianchi-Jassir, Neal Russell, Maya Kohli-Lynch et al.
BACKGROUND: We aimed to provide the first comprehensive estimates of the burden of group B Streptococcus (GBS), including invasive disease in pregnant and postpartum women, fetal infection/stillbirth, and infants. Intrapartum antibiotic prophylaxis is the current mainstay of prevention, reducing ear...
Anne CC Lee, Simon Cousens, Stephen Wall, Susan Niermeyer et al.
BACKGROUND: Of 136 million babies born annually, around 10 million require assistance to breathe. Each year 814,000 neonatal deaths result from intrapartum-related events in term babies (previously "birth asphyxia") and 1.03 million from complications of prematurity. No systematic assessment of mort...
Lola Madrid, Anna C. Seale, Maya Kohli-Lynch, Karen Edmond et al.
BACKGROUND: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasiv...
Rebecca Milton, David Gillespie, Calie Dyer, Khadijeh Taiyari et al.
BACKGROUND: Neonatal sepsis is a primary cause of neonatal mortality and is an urgent global health concern, especially within low-income and middle-income countries (LMICs), where 99% of global neonatal mortality occurs. The aims of this study were to determine the incidence and associations with n...
Fiorella Bianchi-Jassir, Anna C. Seale, Maya Kohli-Lynch, Joy E Lawn et al.
BACKGROUND: Preterm birth complications are the leading cause of deaths among children <5 years of age. Studies have suggested that group B Streptococcus (GBS) maternal rectovaginal colonization during pregnancy may be a risk factor for preterm delivery. This article is the fifth of 11 in a series. ...
Neal Russell, Anna C. Seale, Catherine O’Sullivan, Kirsty Le Doaré et al.
BACKGROUND: Early-onset group B streptococcal disease (EOGBS) occurs in neonates (days 0-6) born to pregnant women who are rectovaginally colonized with group B Streptococcus (GBS), but the risk of EOGBS from vertical transmission has not been systematically reviewed. This article, the seventh in a ...
Francisco M. Kovacs, Emma Garcia, Ana Royuela, Lourdes González et al.
STUDY DESIGN: A cross-sectional, multicenter study. OBJECTIVE: To determine the prevalence of low back pain (LBP), leg pain (LP), and pelvic girdle pain (PGP) in pregnant Spanish women and to identify the factors associated with a higher risk. SUMMARY OF BACKGROUND DATA: Previous studies on the prev...
Neal Russell, Wolfgang Stöhr, Nishad Plakkal, Aislinn Cook et al.
BACKGROUND: There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future ...
Anna C. Seale, Hannah Blencowe, Fiorella Bianchi-Jassir, Nicholas D. Embleton et al.
BACKGROUND: There are an estimated 2.6 million stillbirths each year, many of which are due to infections, especially in low- and middle-income contexts. This paper, the eighth in a series on the burden of group B streptococcal (GBS) disease, aims to estimate the percentage of stillbirths associated...
Saskia Osendarp, Joop MA van Raaij, Gary L. Darmstadt, Abdullah H Baqui et al.
BACKGROUND Infant malnutrition and mortality rates are high in less-developed countries especially in low-birthweight infants. Zinc deficiency is also widely prevalent in these circumstances. We aimed to assess the effect of daily zinc supplements given to pregnant mothers on their infants' growth a...
Kathryn Thomson, Calie Dyer, Feiyan Liu, Kirsty Sands et al.
BACKGROUND: Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicr...
The WHO ACTION Trials Collaborators
BACKGROUND: The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain. METHODS: We conducted a multicountry, randomized trial involving pregnant women between 26 weeks 0 days and 33 weeks 6 days of gestation who were at ri...
Grace Li, Julia Bielicki, ASM Nawshad Uddin Ahmed, Mohammad Shahidul Islam et al.
OBJECTIVE: To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and middle-income country (LMIC) setting to inform the design of an observational study on the burden of unit-level antimicrobial resistance (AMR). DESIG...