Qing Li, Yong Ni, Liren Zhang, Runqiu Jiang et al.
N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possible involvement of m6A modification of mRNA in hypox...
Sajib Chakraborty, Md. Ismail Hosen, Musaddeque Ahmed, Hossain Uddin Shekhar
The acquisition of cancer hallmarks requires molecular alterations at multiple levels including genome, epigenome, transcriptome, proteome, and metabolome. In the past decade, numerous attempts have been made to untangle the molecular mechanisms of carcinogenesis involving single OMICS approaches su...
Maurice W. Southworth, Eric Adam, Daniel Panne, Robyn Byer et al.
Inteins are protein splicing elements that mediate their excision from precursor proteins and the joining of the flanking protein sequences (exteins). In this study, protein splicing was controlled by splitting precursor proteins within the Psp Pol-1 intein and expressing the resultant fragments in ...
Shirley M. Myers, Charis Eng, Bruce A.J. Ponder, Lois M. Mulligan
The RET proto-oncogene, which encodes a receptor tyrosine kinase, displays multiple alternative splicing variants. Splicing of sequences 3' of exon 19 to generate several coding and untranslated region (UTR) sequences has been previously reported. We have sequenced the full length RET coding region ...
Bekim Sadiković, Maisa Yoshimoto, Susan Chilton‐MacNeill, Paul S. Thorner et al.
Altered gene expression in tumors can be caused by copy number alterations to DNA or mutation affecting coding or regulatory regions of genes. However, epigenetic events may also influence gene expression. Malignant cells can show major disruptions in DNA methylation profiles, which are manifested a...
Bin Li, Xi Wen, Ying Bai, Xue Liu et al.
Abstract Vascular repair is considered a key restorative measure to improve long-term outcomes after ischemic stroke. N 6 -methyladenosine (m 6 A), the most prevalent internal modification in eukaryotic mRNAs, functionally mediates vascular repair. However, whether circular RNA SCMH1 (circSCMH1) pro...
Yufei Lan, Boyang Liu, Hongbo Guo
N(6)-methyladenosine (m(6)A) is the most abundant modification in eukaryotic cells, and it regulates RNA transcription, processing, splicing, degradation, and translation. Long non-coding RNAs (lncRNAs), as transcriptional products with no or limited protein coding ability more than 200 nt in length...
Zhidong Yuan, Xiao Sun, Hongde Liu, Jianming Xie
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by targeting mRNAs for translation repression or mRNA degradation. Many miRNAs are being discovered and studied, but in most cases their origin, evolution and function remain unclear. Here, we characterized miRNAs d...
Chenghao Guo, Zhuanzhuan Che, Junjie Yue, Peng Xie et al.
Release of paused RNA polymerase II (Pol II) requires incorporation of the positive transcription elongation factor b (P-TEFb) into the super elongation complex (SEC), thus resulting in rapid yet synchronous transcriptional activation. However, the mechanism underlying dynamic transition of P-TEFb f...
Zhipeng Xu, Shuqiu Chen, Ruiji Liu, Hui Chen et al.
BACKGROUND: Increasing evidence has demonstrated that circular RNAs (circRNAs) are implicated in cancer progression. However, the aberrant expression and biological functions of circRNAs in clear cell renal cell carcinoma (cRCC) remain largely elusive. METHOD: Differentially expressed circRNAs in cR...
Mei Cao, Huaqing Li, Jian Zhao, Juan Cui et al.
Alzheimer’s disease (AD) is an age- and gender-associated brain disorder. Long noncoding RNAs (lncRNAs) have emerged as key regulators of brain development, homeostasis, and pathologies. Here we utilized gene array datasets and bioinformatics analysis to identify differentially-expressed age- and ge...
Elisabetta Valentini, Michele Zampieri, Marco Malavolta, Maria Giulia Bacalini et al.
Aging | doi:10.18632/aging.101022. Elisabetta Valentini, Michele Zampieri, Marco Malavolta, Maria Giulia Bacalini, Roberta Calabrese, Tiziana Guastafierro, Anna Reale, Claudio Franceschi, Antti Hervonen, Bernhard Koller, Jürgen Bernhardt, P. Eline Slagboom, Olivier Toussaint, Ewa Sikora, Efstathios...
Qian Li, Liwen Yu, Amy Gao, Ruiqing Ren et al.
Background: Atherosclerosis is a chronic inflammatory disease, in which macrophages determine the progression of atherosclerotic plaques. However, no studies have investigated how METTL3 (methyltransferase like 3) in macrophages affects atherosclerotic plaque formation in vivo. Additionally, whether...
Tania Islam, Rezanur Rahman, Esra Göv, Beste Turanlı et al.
The head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world, but robust biomarkers and diagnostics are still not available. This study provides in-depth insights from systems biology analyses to identify molecular biomarker signatures to inform systematic drug ta...
Farhadul Islam, Vinod Gopalan, Alfred K. Lam
FAM134B (family with sequence similarity 134, member B)/RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that re...