LZ Sommer, Steve Iscoe, Ari Robicsek, Joshua M. Kruger et al.
Many clinical and research situations require maintenance of isocapnia, which occurs when alveolar ventilation (V'A) is matched to CO2 production. A simple, passive circuit that minimizes changes in V'A during hyperpnoea was devised. It is comprised of a manifold, with two gas inlets, attached to th...
GM Monsur Habib, Roberto Rabinovich, Kalyani Divgi, Salahuddin Ahmed et al.
Pulmonary rehabilitation (PR) is a guideline-recommended multifaceted intervention that improves the physical and psychological well-being of people with chronic respiratory diseases (CRDs), though most of the evidence derives from trials in high-resource settings. In low- and middle-income countrie...
Kane M. High, Michael T. Snider, Russell Richard, Garry B. Russell et al.
In patients with severe adult respiratory distress syndrome, mechanical ventilation may not be able to ensure gas exchange sufficient to sustain life. We report the use of an intravenous oxygenator (IVOX) in five patients who were suffering from severe adult respiratory distress syndrome as a result...
Hamish Graham, Carina King, Ahmed Ehsanur Rahman, Freddy Eric Kitutu et al.
Executive summary<br/>“Oxygen delayed is life denied,” COVID-19 survivor, Kenya<br/><br/>Medical oxygen is an essential medicine that has been in clinical use for over 150 years. It is required at every level of the healthcare system for children and adults with a wide range of acute and chronic con...
Larry J. Byford, Joe Finkler, A. B. Froese
In diffuse lung injury, optimal oxygenation occurs with high-frequency oscillatory ventilation (HFO-A, where A is active expiratory phase) when sustained inflations (SI) are applied periodically to recruit lung volume. Theoretically pulsed pressures may be safer and more effective than static pressu...
Thomas P. Green, Frank W. Moler, Denise M. Goodman
OBJECTIVE: Extracorporeal membrane oxygenation (ECMO) has been used with increasing frequency for respiratory failure that is unresponsive to conventional therapy. We examined the relationship between duration of ECMO and outcome to understand whether prolonged ECMO (duration of the procedure for > ...
Golam Rabbani, Sheikh Mohammed Shariful Islam, Muhammad Aziz Rahman, Nuhu Amin et al.
: We found that patients with pre-existing COPD had more than 3 times higher risk of mortality and severe COVID-19. There is a need to identify patients with pre-existing COPD during the pandemic so that early interventions can be aimed at this group of patients.
C. Richard Dunn, Deon L. Dunn, Kenneth Μ. Moser, Moser
Musaddique Hussain, Shahzada Khurram Syed, Mobeen Fatima, Saira Shaukat et al.
Acute respiratory distress syndrome (ARDS) is an overwhelming inflammatory disorder of the lung due to direct and indirect insults to the lungs. ARDS is characterized by increased vascular permeability, protein-rich edema, diffuse alveolar infiltrate, and loss of aerated lung tissue, leading to decr...
Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Areef Ahsan et al.
Epidemiology, ventilator management, and outcome in patients receiving invasive ventilation in intensive care units (ICUs) in middle-income countries are largely unknown. PRactice of VENTilation in Middle-income Countries is an international multicenter 4-week observational study of invasively venti...
Nikhil T Awatade, Peter Wark, Andrew S. L. Chan, SM Abdullah Al Mamun et al.
Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and mortality worldwide. There is mounting evidence suggesting that COPD patients are at increased risk of severe COVID-19 outcomes; however, it remains unclear whether they are more susceptible to acquiring SARS-CoV-2 in...
Virginie Lemiale, Jérôme Lambert, Emmanuel Canet, Djamel Mokart et al.
BACKGROUND: We sought to identify risk factors for mechanical ventilation in patients with malignancies and acute respiratory failure (ARF). METHODS: We analyzed data from a previous randomized controlled trial in which nonintubated oncology and hematology subjects with ARF were randomized to early ...
Matthew R. Grigsby, Trishul Siddharthan, Suzanne L. Pollard, Muhammad Ashique Haider Chowdhury et al.
The relationship of body mass index (BMI) with lung function and COPD has been previously described in several high-income settings. However, few studies have examined this relationship in resource-limited settings where being underweight is more common. We evaluated the association between BMI and ...
M. Helm, Gert‐Jan Kremers, L. Lampl, B. Hoßfeld
BACKGROUND: Pre-hospital tracheal intubation (TI) is an important but difficult procedure with the potential to produce hypoxaemia. The aim of this study was to determine the incidence of desaturation episodes during out-of-hospital rapid sequence induction (RSI) and TI by the medical team of a Germ...
K. Munckton, Kwok M. Ho, Geoffrey Dobb, Mike Das-Gupta et al.
Noninvasive ventilation by facemask is commonly used for patients with respiratory failure. We evaluated the pressure exerted by two types of facemask on the faces of 12 healthy volunteers while they were being given different levels of continuous or bi-level positive airway pressure ventilation. Th...