Claire Wainwright, J.S. Elborn, Bonnie W. Ramsey, Gautham Marigowda et al.
BACKGROUND: Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease in patients with cystic fibrosis. METHODS: through week 24 (calculated as a percentage) w...
Sarah K. Wise, Cecelia Damask, Lauren T. Roland, Charles S. Ebert et al.
BACKGROUND: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics ...
Jean Bousquet, Holger J. Schünemann, João Fonseca, Bolesław Samoliński et al.
Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient e...
Ruby Pawankar, Giorgio Walter Canonica, Stephen T. Holgate, Richard F. Lockey
The prevalence of allergic diseases and asthma is increasing worldwide, particularly in low and middle-income countries. Moreover, the complexity and severity of allergic diseases, including asthma, continue to increase especially in children and young adults, who are bearing the greatest burden of ...
Lorcan McGarvey, Claire A. Butler, Susan Stokesberry, Liam Polley et al.
Background The airway epithelium is exposed to a range of physical and chemical irritants in the environment that are known to trigger asthma. Transient receptor potential (TRP) cation channels play a central role in sensory responses to noxious physical and chemical stimuli. Recent genetic evidence...
Nihad Karim Chowdhury, Muhammad Ashad Kabir, Md. Muhtadir Rahman, Sheikh Mohammed Shariful Islam
This research aims to analyze the performance of state-of-the-art machine learning techniques for classifying COVID-19 from cough sounds and to identify the model(s) that consistently perform well across different cough datasets. Different performance evaluation metrics (precision, sensitivity, spec...
Mahdi Abastabar, Iman Haghani, Fatemeh Ahangarkani, Mohammad Sadegh Rezai et al.
Candida auris is a multidrug-resistant yeast emerging in immunocompromised and in otherwise healthy individuals. Due to difficulties in microbiological identification of C. auris because of the lack of available laboratory technology in developing countries, the number of patients affected is most l...
Éric Van Ganse, L Kaufman, M.P. Derde, Jean Claude Yernault et al.
A meta-analysis of clinical trials of antihistamines was performed to assess the risk-benefit ratio of this therapeutic class in asthma. Double-blind randomized placebo-controlled trials assessing lung function changes under repeated use of antihistamine in adult asthma were selected, and the qualit...
Mohammad Anwar Hossain, K M Amran Hossain, Karen Saunders, Zakir Uddin et al.
BACKGROUND: The objective of this study was to identify the prevalence of long COVID symptoms in a large cohort of people living with and affected by long COVID and identify any potential associated risk factors. METHODS: A prospective survey was undertaken of an inception cohort of confirmed people...
David Price, Shailen Shah, Sanjay Bhatia, Claus Bachert et al.
BACKGROUND AND OBJECTIVE: MP29-02 (Dymista), a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP), is significantly better than first-line therapy for the treatment of moderate-to-severe seasonal allergic rhinitis (SAR), and is well tolerated following 52 ...
Prashant Jarhyan, Anastasia Hutchinson, Damien Khaw, Dorairaj Prabhakaran et al.
Objective: To estimate the prevalence of chronic obstructive pulmonary disease (COPD) and chronic bronchitis in eight countries in South Asia through a systematic review and meta-analysis. Methods: We searched MEDLINE® Complete, Web of Science, Embase®, Scopus, CINAHL and reference lists of screened...
A. R. Cameron, C.F. Johnston, C. T. Kirkpatrick, Melanie C. A. Kirkpatrick
The effect of inhibitory nerve stimulation on the mechanical, membrane potential and membrane conductance responses of isolated bovine tracheal smooth muscle has been studied. Membrane responses were measured in a sucrose-gap apparatus. In order to record inhibitory responses, it was necessary to in...
Vincenza Snow, Christel Mottur-Pilson, Ralph Gonzales
Position Papers20 March 2001Principles of Appropriate Antibiotic Use for Treatment of Nonspecific Upper Respiratory Tract Infections in AdultsVincenza Snow, MD, Christel Mottur-Pilson, PhD, and Ralph Gonzales, MD, MSPH, for the American College of Physicians–American Society of Internal Medicine*Vin...
Jan Hagemann, Gabrielle L. Onorato, Marek Jutel, Cezmi A. Akdiş et al.
BACKGROUND: Although there are many asymptomatic patients, one of the problems of COVID-19 is early recognition of the disease. COVID-19 symptoms are polymorphic and may include upper respiratory symptoms. However, COVID-19 symptoms may be mistaken with the common cold or allergic rhinitis. An ARIA-...
Enrique Rojas‐Ramos, Ana Francisca Avalos, Lorenzo Perez-Fernandez, F. Cuevas-Schacht et al.
Eosinophil recruitment into the airways is a feature of asthma in children. However, the mechanisms by which these cells migrate into the airways are not fully understood. The present study investigated the presence of the eosinophil-activating chemokines regulated on activation, normal T-cell expre...