J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
BACKGROUND: Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility. OBJECTIVE: A...
Amy L. Rice, Rebecca J. Stoltzfus, Andrés de Francisco, J. Chakraborty et al.
The effects of maternal postpartum vitamin A or beta-carotene supplementation on maternal and infant serum retinol concentrations, modified relative dose-response (MRDR) ratios and breast milk vitamin A concentrations were assessed during a community-based trial in Matlab, Bangladesh. At 1-3 wk post...
Rolf Klemm, Alain Labrique, Parul Christian, Mahbubur Rashid et al.
OBJECTIVES: We assessed the effect of supplementing newborns with 50000 IU of vitamin A on all-cause infant mortality through 24 weeks of age. PATIENTS AND METHODS: This was a community-based, double-masked, cluster-randomized, placebo-controlled trial conducted in 19 unions in rural northwest Bangl...
Fausto Andreola, Pedro M. Fernández‐Salguero, Maria Vincenza Chiantore, Martin Petkovich et al.
Livers from aryl hydrocarbon receptor-null mice showed a 3-fold increase in retinoids and a 65% decrease in retinoic acid metabolism. Levels of expression of the retinoic acid 4-hydroxylase, P450RAI, did not change, whereas cytochrome P4501A2 levels were lower in the null mouse, as shown earlier; ho...
Julia E. Heck, Mary V. Gamble, Yu Chen, Joseph H. Graziano et al.
Background Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser ...
Yana Chervona, Megan N. Hall, Adriana Arita, Fen Wu et al.
BACKGROUND: Exposure to arsenic (As) is associated with an increased risk of several cancers as well as cardiovascular disease, and childhood neuro-developmental deficits. Arsenic compounds are weakly mutagenic, alter gene expression and posttranslational histone modifications (PTHMs) in vitro. METH...
Brandon L. Pierce, L. Tong, Maria Argos, Jianchang Gao et al.
BACKGROUND: Arsenic exposure through drinking water is a serious global health issue. Observational studies suggest that individuals who metabolize arsenic efficiently are at lower risk for toxicities such as arsenical skin lesions. Using two single nucleotide polymorphisms(SNPs) in the 10q24.32 reg...
Faruque Parvez, Yu Chen, Paul W. Brandt‐Rauf, Alfred Bernard et al.
BACKGROUND: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bia...
Suzanne Filteau, Amy L. Rice, Jennifer J Ball, J. Chakraborty et al.
Background Vitamin A supplementation of mothers postpartum may improve infant health, not only by increasing vitamin A delivery to the infant through breast milk but also by increasing delivery of milk immune factors. Our hypothesis was that postpartum supplementation with vitamin A increases milk c...
Molly L. Kile, Elaine Hoffman, Yu‐Mei Hsueh, Sakila Afroz et al.
BACKGROUND: Urinary arsenic metabolites (UAs) are used as biomarkers of exposure and metabolism. OBJECTIVES: To characterize inter- and intraindividual variability in UAs in healthy individuals. METHODS: In a longitudinal study conducted in Bangladesh, we collected water and spot urine samples from ...
Kathleen M. McCarty, Yen‐Ching Chen, Quazi Quamruzzaman, Mahmuder Rahman et al.
OBJECTIVE: We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. METHODS: A case-control study of 600 cases and 600 controls that were frequency matched on age and sex w...
Yu Chen, Habibul Ahsan, Vesna Slavkovich, Gretchen Loeffler Peltier et al.
BACKGROUND: The long-term effects of arsenic exposure from drinking water at levels < 300 microg/L and the risk of diabetes mellitus remains a controversial topic. METHOD: We conducted a population-based cross-sectional study using baseline data from 11,319 participants in the Health Effects of Arse...
D. N. Guha Mazumder, Uday C. Ghoshal, Jayanta Saha, Amal Santra et al.
INTRODUCTION: Chronic arsenic toxicity producing various clinical manifestations is currently epidemic in West Bengal, India, Bangladesh, and other regions of the world. Animal studies have indicated that 2,3-dimercaptosuccinic acid can be used as an oral chelating agent. A prospective, double-blind...
Roy Sk, Md. Ariful Islam, Ayesha Molla, S. M. Akramuzzaman et al.
Objectives To evaluate the effect of vitamin A supplementation 24 h after delivery on breastmilk retinol concentration. Methods Fifty low income women were randomly assigned to a single oral dose of 209 micromol of Vitamin A or none at delivery. Maternal serum and breastmilk retinol levels and infan...
Rick J. Jansen, Maria Argos, Tong Lin, Jiabei Li et al.
BACKGROUND: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine ...