Giacomo Bellani, John G. Laffey, Tài Pham, Eddy Fan et al.
IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS). OBJECTIVES: To evaluate intensive care unit (ICU) incidence and outcome of ARDS and to assess clinician recognition, ventilation manag...
Neal Russell, Anna C. Seale, Megan O’Driscoll, Catherine O’Sullivan et al.
BACKGROUND: Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide. METHODS: We conducted systematic literature reviews (PubMed/Medline,...
Luregn J. Schlapbach, R. Scott Watson, Lauren R. Sorce, Andrew C. Argent et al.
Importance: Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) defined sepsis as life-threatening org...
Lola Madrid, Anna C. Seale, Maya Kohli-Lynch, Karen Edmond et al.
BACKGROUND: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasiv...
François Lamontagne, Marie-Hélène Masse, Julie Ménard, Sheila Sprague et al.
BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction. METHODS: In this randomized, placebo-controlled tri...
Guillaume Émériaud, Yolanda M. López‐Fernández, Narayan P. Iyer, Melania M. Bembea et al.
OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed. D...
Daren K. Heyland, Allan Garland, Sean M. Bagshaw, Deborah Cook et al.
Purpose Increasingly, very old patients are admitted to Intensive Care Units (ICUs). The objective of this study was to describe 12-month outcomes of these patients and determine which characteristics are associated with a return to baseline physical function 1 year later. Methods In this prospectiv...
Jason Phua, Younsuck Koh, Bin Du, Yunqiang Tang et al.
OBJECTIVES: To assess the compliance of Asian intensive care units and hospitals to the Surviving Sepsis Campaign's resuscitation and management bundles. Secondary objectives were to evaluate the impact of compliance on mortality and the organisational characteristics of hospitals that were associat...
Arjen M. Dondorp, Can İnce, Prakaykaew Charunwatthana, Josh Hanson et al.
BACKGROUND: This study sought to describe and quantify microcirculatory changes in the mucosal surfaces of patients with severe malaria, by direct in vivo observation using orthogonal polarization spectral (OPS) imaging. METHODS: The microcirculation in the rectal mucosa of adult patients with sever...
Rebecca Milton, David Gillespie, Calie Dyer, Khadijeh Taiyari et al.
BACKGROUND: Neonatal sepsis is a primary cause of neonatal mortality and is an urgent global health concern, especially within low-income and middle-income countries (LMICs), where 99% of global neonatal mortality occurs. The aims of this study were to determine the incidence and associations with n...
Kristina E. Rudd, Christopher Seymour, Adam R. Aluisio, Marc E. Augustin et al.
Importance: The quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score has not been well-evaluated in low- and middle-income countries (LMICs). Objective: To assess the association of qSOFA with excess hospital death among patients with suspected infection in LMICs and to compare q...
Kirsty Le Doaré, Megan O’Driscoll, Kim Turner, Farah Seedat et al.
BACKGROUND: Intrapartum antibiotic chemoprophylaxis (IAP) prevents most early-onset group B streptococcal (GBS) disease. However, there is no description of how IAP is used around the world. This article is the sixth in a series estimating the burden of GBS disease. Here we aimed to review GBS scree...
L. Nelson Sanchez‐Pinto, Tellen D. Bennett, Peter E. DeWitt, Seth Russell et al.
Importance: The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis and septic shock using measures of organ dysfunction through a data-driven approach. Objective: To derive and validate novel criteria for...
Neal Russell, Wolfgang Stöhr, Nishad Plakkal, Aislinn Cook et al.
BACKGROUND: There is limited data on antibiotic treatment in hospitalized neonates in low- and middle-income countries (LMICs). We aimed to describe patterns of antibiotic use, pathogens, and clinical outcomes, and to develop a severity score predicting mortality in neonatal sepsis to inform future ...
Jonathan A. Silversides, Ruxandra Pinto, Rottem Kuint, Ron Wald et al.
INTRODUCTION: In this cohort study, we explored the relationship between fluid balance, intradialytic hypotension and outcomes in critically ill patients with acute kidney injury (AKI) who received renal replacement therapy (RRT). METHODS: We analysed prospectively collected registry data on patient...