Jordan Peck, James C. Benneyan, Deborah Nightingale, Stephan A. Gaehde
OBJECTIVES: The objectives were to evaluate three models that use information gathered during triage to predict, in real time, the number of emergency department (ED) patients who subsequently will be admitted to a hospital inpatient unit (IU) and to introduce a new methodology for implementing thes...
Jennifer Hall, Nadine Hack Adams, Linda Bartlett, Anna C. Seale et al.
Background. Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide.
Jason E. Buick, Ian R. Drennan, Damon C. Scales, Steven C. Brooks et al.
Background Considerable effort has gone into improving outcomes from out-of-hospital cardiac arrest (OHCA). Studies suggest that survival is improving; however, prior studies had insufficient data to pursue the relationship between markers of guideline compliance and temporal trends. The objective o...
Ozan Akça, Anthony G. Doufas, Nobutada Morioka, Steve Iscoe et al.
BACKGROUND: Wound infections are common, serious, surgical complications. Oxidative killing by neutrophils is the primary defense against surgical pathogens and increasing intraoperative tissue oxygen tension markedly reduces the risk of such infections. Since hypercapnia improves cardiac output and...
Waheeda Nargis, Md Ibrahim, Borhan Uddin Ahamed
BACKGROUND: Early diagnosis and appropriate therapy of sepsis is a daily challenge in intensive care units (ICUs) despite the advances in critical care medicine. Procalcitonin (PCT); an innovative laboratory marker, has been recently proven valuable worldwide in this regard. OBJECTIVES: This study w...
Kathryn Thomson, Calie Dyer, Feiyan Liu, Kirsty Sands et al.
BACKGROUND: Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicr...
Josh Hanson, Sue J. Lee, Sanjib Mohanty, M. Abul Faiz et al.
BACKGROUND: World Health Organization treatment guidelines recommend that adults with severe malaria be admitted to an intensive care unit (ICU). However, ICU facilities are limited in the resource-poor settings where most malaria occurs. Identification of patients at greater risk of complications m...
Kusum Menon, Luregn J. Schlapbach, Samuel Akech, Andrew Argent et al.
OBJECTIVE: To determine the associations of demographic, clinical, laboratory, organ dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic shock in children with infection and 2) multiple organ dysfunction or death in children with sepsis, severe sepsis, or sept...
ASM Nawshad Uddin Ahmed, M. A. K. Azad Chowdhury, Mahbul Hoque, Gary L. Darmstadt
The present article is a descriptive analysis of clinical and bacteriological profile of neonatal septicemia in a tertiary care hospital in Bangladesh. Eighty six neonates with suspected sepsis were enrolled, out of which 30 were culture positive. Clinical presentation was non-specific. Majority (70...
Daren K. Heyland, Elsie Konopad, Thomas Noseworthy, Richard Johnston et al.
Objective To compare the cost and consequences of a policy of continuing to care for patients with a prolonged stay in the ICU with a proposed policy of withdrawing support. Design Economic evaluation using data derived from a prospective cohort study. Setting Adult medical/surgical ICU in a tertiar...
Peter Serina, Ian Riley, Andrea Stewart, Spencer L James et al.
BACKGROUND: Reliable data on the distribution of causes of death (COD) in a population are fundamental to good public health practice. In the absence of comprehensive medical certification of deaths, the only feasible way to collect essential mortality data is verbal autopsy (VA). The Tariff Method ...
Andrew Li, Lowell Ling, Hanyu Qin, Yaseen M. Arabi et al.
Abstract Rationale Directly comparative data on sepsis epidemiology and sepsis bundle implementation in countries of differing national wealth remain sparse. Objectives To evaluate across countries/regions of differing income status in Asia 1) the prevalence, causes, and outcomes of sepsis as a reas...
Mahbuba Meem, Joyanta K. Modak, Roman Mortuza, Mahboob Morshed et al.
BACKGROUND: Neonatal infections annually claim lives of 1.4 million neonates worldwide. Until now, there is no ideal diagnostic test for detecting sepsis and thus management of possible sepsis cases often depends on clinical algorithm leading to empirical treatment. This often results in unnecessary...
Jianfeng Xie, Daniel Hungerford, Hui Chen, Simon T. Abrams et al.
Mohammad Shafiqur Rahman, Gareth Ambler, Babak Choodari‐Oskooei, Rumana Omar
BACKGROUND: When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have been proposed, there is only limited guidance regarding their use in the contex...