Samuel A.J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath et al.
Abstract Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one indiv...
Shahedur Rahman, Rezuanul Islam
Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-ass...
Aneesa Ansari, Md. Shahedur Rahman, Subbroto Kumar Saha, Forhad Karim Saikot et al.
In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involve...
Md. Abdul Hannan, Raju Dash, Abdullah Al Mamun Sohag, Md. Nazmul Haque et al.
Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related disorders, including neurodegenerative diseases and ischemic stroke, which are the major causes of dementia. The Nrf2-ARE (nuclear factor erythroid 2-related factor 2/antioxidant responsive element antioxidan...
Partha Biswas, Dipta Dey, Polash Kumar Biswas, Tanjim Ishraq Rahaman et al.
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible fo...
Md. Habibur Rahman, Rokeya Akter, Tanima Bhattacharya, Mohamed M. Abdel‐Daim et al.
Alzheimer’s disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of Aβ (β-amyloid peptides), phosphorylation of tau-proteins, and chronic infla...
Saikat Kumar Poddar, Ali Ehsan Sifat, Sanjana Haque, Noor Ahmed Nahid et al.
Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis. Although the biosynthetic pathway of NMN varies between eukaryote and prokaryote, two pathways are mainly followed in case of eukaryotic...
Md. Sahab Uddin, Abdullah Al Mamun, Md. Tanvir Kabir, Jamil Ahmad et al.
Neurodegenerative diseases (NDs) are characterized by disorders with progressive deterioration of the structure and/or function of neurons. Genetic mutations can lead to many NDs. Nevertheless, neurodegeneration can also take place due to several biological processes. The pathogenesis of several NDs...
Raushanara Akter, Afrina Afrose, Md. Rashidur Rahman, Rakhi Chowdhury et al.
Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by binding with biological macromolecules, si...
Zhendong Zhu, Rongnan Li, Xiaoteng Fan, Yinghua Lv et al.
Mammalian sperm is highly susceptible to the reactive oxygen species (ROS) stress caused by biochemical and physical modifications during the cryopreservation process. 5<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:msup><mml:mrow/><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:...
Fahadul Islam, Mohamed H. Nafady, Md. Rezaul Islam, Susmita Saha et al.
Alzheimer's disease (AD) is the most common cause of dementia and cognitive impairment; yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative stress, and inflammation in AD is pathogenic. The accumulation of amyloid-beta (Aβ) peptides in these neurocognitive a...
Jibon Kumar Paul, Mahir Azmal, ANM Shah Newaz Been Haque, Omar Faruk Talukder et al.
• Phytochemicals are bioactive compounds with therapeutic potential. • Phytochemicals could modulate key cellular functions and disease progression. • Phytochemicals interact with crucial signaling and biological pathways. • Despite their promising therapeutic benefits, many challenges remain for cl...
Rubayat Khan, Saif Nirzhor, Raushanara Akter
Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide⁺ (NAD⁺) dependent enzyme and stress response protein that has sparked the curiosity of many researchers in different branches of the biomedical sciences. A unique member of the known Sirtuin family, SIRT6 has several different functions in mul...
Guo Zhao, Junfeng Zhen, Xinyuan Liu, J.J. Guo et al.
Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism phy...
Philippe Jeandet, Eduardo Sobarzo‐Sánchez, Md. Sahab Uddin, Roque Bru‐Martínez et al.
Most drugs or the natural substances reputed to display some biological activity are hydrophobic molecules that demonstrate low bioavailability regardless of their mode of absorption. Resveratrol and its derivatives belong to the chemical group of stilbenes; while stilbenes are known to possess very...