Jeremiah Chakaya, Mishal Khan, Francine Ntoumi, Eleni Aklillu et al.
The October 2020 Global TB report reviews TB control strategies and United Nations (UN) targets set in the political declaration at the September 2018 UN General Assembly high-level meeting on TB held in New York. Progress in TB care and prevention has been very slow. In 2019, TB remained the most c...
Karine Brudey, Jeffrey Driscoll, Leen Rigouts, Wolfgang M. Prodinger et al.
BACKGROUND: The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is the widely used PCR-based reverse-hybridization blotting technique that assays the genetic dive...
Armand Van Deun, Aung Kya Jai Maug, Md Abdul Hamid Salim, Pankaj Das et al.
RATIONALE: Based on expert opinion, the global guidelines for management of multidrug-resistant tuberculosis impose lengthy and often poorly tolerated treatments. OBJECTIVES: This observational study evaluates the effectiveness of standardized regimens for patients with proven multidrug-resistant tu...
Andrew Nunn, Patrick Phillips, Sarah Meredith, Chen‐Yuan Chiang et al.
BACKGROUND: Cohort studies in Bangladesh showed promising cure rates among patients with multidrug-resistant tuberculosis who received existing drugs in regimens shorter than that recommended by the World Health Organization (WHO) in 2011. METHODS: at 132 weeks and at a previous occasion, with no in...
Stephen M. Graham, Tahmeed Ahmed, Farhana Amanullah, Renee Browning et al.
There is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case defini...
Richard J. Whittington, Karsten Donat, M.F. Weber, D.F. Kelton et al.
Paratuberculosis, a chronic disease affecting ruminant livestock, is caused by Mycobacterium avium subsp. paratuberculosis (MAP). It has direct and indirect economic costs, impacts animal welfare and arouses public health concerns. In a survey of 48 countries we found paratuberculosis to be very com...
K. J. M. Aung, Armand Van Deun, Erik De Clercq, Mihir Ranjan Sarker et al.
SETTING: Tuberculosis (TB) program, Damien Foundation Projects, Bangladesh. OBJECTIVE: To summarize the outcome and its determinants of the first treatment for multidrug-resistant TB using a standardized regimen consisting of a minimum 9 months. DESIGN: This was a prospective, observational study of...
Khalequ Zaman
Tuberculosis (TB) is an ancient disease that has affected mankind for more than 4,000 years (1). It is a chronic disease caused by the bacillus Mycobacterium tuberculosis and spreads from person to person through air. TB usually affects the lungs but it can also affect other parts of the body, such ...
Sayera Banu, Nadine Honoré, Brigitte Saint‐Joanis, Dana J. Philpott et al.
Mycobacterium tuberculosis H37Rv contains 67 PE-PGRS genes, with multiple tandem repetitive sequences, encoding closely related proteins that are exceptionally rich in glycine and alanine. As no functional information was available, 10 of these genes were selected and shown to be expressed in vitro ...
Armand Van Deun, K. J. M. Aung, Valentin Bola, Rossin Lebeke et al.
The rapid diagnosis of rifampin resistance is hampered by a reported insufficient specificity of molecular techniques for detection of rpoB mutations. Our objective for this study was to document the prevalence and prognostic value of rpoB mutations with unclear phenotypic resistance. The study desi...
Jean Jacques Noubiap, Jobert Richie Nansseu, Ulrich Flore Nyaga, Jan René Nkeck et al.
BackgroundAlthough diabetes and poor glycaemic control significantly increase the risk of tuberculosis and adversely affect tuberculosis treatment outcomes, the global burden of diabetes in the context of tuberculosis remains unknown. We did a systematic review and meta-analysis to estimate the prev...
Giovanni Battista Migliori, Simon Tiberi, Alimuddin Zumla, Eskild Petersen et al.
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Glob...
Vineet Ahuja, Rakesh K. Tandon
The Asia-Pacific region has been marked as an area with a low incidence of inflammatory bowel disease (IBD), although confusion always existed as to whether this low incidence was a result of low diagnostic awareness, a high incidence of infective diarrhoea and its diagnostic overlap or a true low i...
Júlia Moreira Pescarini, Agostino Strina, Joilda Silva Nery, Lacita Menezes Skalinski et al.
Over 200,000 new cases of leprosy are detected each year, of which approximately 7% are associated with grade-2 disabilities (G2Ds). For achieving leprosy elimination, one of the main challenges will be targeting higher risk groups within endemic communities. Nevertheless, the socioeconomic risk mar...
Jacob Creswell, Andrew James Codlin, Emmanuel André, Mark A. Micek et al.
BACKGROUND: The Xpert MTB/RIF assay has garnered significant interest as a sensitive and rapid diagnostic tool to improve detection of sensitive and drug resistant tuberculosis. However, most existing literature has described the performance of MTB/RIF testing only in study conditions; little inform...