Mohanraj Ramachandran, Carl D. Kirkwood, Leanne Unicomb, Nigel A. Cunliffe et al.
Between 1992 and 1998, serotype G9 human rotavirus (RV) strains have been detected in 10 countries, including Thailand, India, Brazil, Bangladesh, Malawi, Italy, France, the United States, the United Kingdom, and Australia, suggesting the possible emergence of the fifth common serotype worldwide. Un...
M. Steven Oberste, Kaija Maher, W. Allan Nix, Suzanne M. Michele et al.
Molecular methods have enabled the rapid identification of new enterovirus (EV) serotypes that are untypeable using existing neutralizing antisera. As a result, sequencing of the VP1 capsid gene has been developed as a surrogate for antigenic typing to distinguish enterovirus types. In this study, 1...
Jelle Matthijnssens, Mustafizur Rahman, Xuelei Yang, Thomas Delbeke et al.
Several G8P[6] and G8P[8] rotavirus strains were isolated from hospitalized patients in the Democratic Republic of Congo in 2003. To investigate their overall genomic relatedness and to determine to which genogroup they belonged, the complete genomes of strains DRC88 (G8P[8]) and DRC86 (G8P[6]) were...
M. Steven Oberste, Suzanne M. Michele, Kaija Maher, David Schnurr et al.
Sequencing of the gene that encodes the capsid protein VP1 has been used as a surrogate for antigenic typing in order to distinguish enterovirus serotypes; three new serotypes were identified recently by this method. In this study, 14 enterovirus isolates from six countries were characterized as mem...
Md. Mijanur Rahman, Md. Habib Ullah Masum, Shah Wajed, Asma Talukder
The present SARS-CoV-2 induced COVID-19 pandemic is responsible for millions of deaths, illnesses, and economic loss worldwide. There are 21 COVID-19 vaccines from different platforms approved worldwide for emergency use until 13 August 2021. Later, BNT162b2 obtained full approval from the FDA. The ...
Olivier Escaffre, Cyril Le Nouën, Michel Amelot, Xavier Ambroggio et al.
Infectious bursal disease virus (IBDV) causes an economically significant disease of chickens worldwide. Very virulent IBDV (vvIBDV) strains have emerged and induce as much as 60% mortality. The molecular basis for vvIBDV pathogenicity is not understood, and the relative contributions of the two gen...
Beth D. Kirkpatrick, E. Ross Colgate, Josyf C. Mychaleckyj, Rashidul Haque et al.
Oral vaccines appear less effective in children in the developing world. Proposed biologic reasons include concurrent enteric infections, malnutrition, breast milk interference, and environmental enteropathy (EE). Rigorous study design and careful data management are essential to begin to understand...
Khalequ Zaman, David A. Sack, Mohammad Yunus, Shams El Arifeen et al.
Co-administration of oral live-attenuated human rotavirus vaccine RIX4414 (Rotarix) and oral polio vaccine (OPV) was assessed. Healthy infants were randomised to receive 2-doses of either: RIX4414 or placebo co-administered with OPV (12 and 16 weeks of age); or RIX4414 or placebo given 15 days after...
Abhijeet Anand, Khalequ Zaman, Concepción F. Estívariz, Mohammad Yunus et al.
Introduction: Inactivated poliovirus vaccine (IPV) introduction and phased oral poliovirus vaccine (OPV) cessation are essential for eradication of polio. Methods: Healthy 6-week old infants in Bangladesh were randomized to one of five study arms: receipt of trivalent OPV (tOPV) or bivalent OPV (bOP...
Mami Taniuchi, James A Platts-Mills, Sharmin Begum, Md. Jashim Uddin et al.
BACKGROUND: Oral polio vaccine (OPV) and rotavirus vaccine (RV) exhibit poorer performance in low-income settings compared to high-income settings. Prior studies have suggested an inhibitory effect of concurrent non-polio enterovirus (NPEV) infection, but the impact of other enteric infections has n...
Betty A. Brown, Kaija Maher, Mary R. Flemister, Pejman Naraghi‐Arani et al.
Molecular methods, based on sequencing the region encoding the VP1 major capsid protein, have recently become the gold standard for enterovirus typing. In the most commonly used scheme, sequences more than 75% identical (>85% amino acid identity) in complete or partial VP1 sequence are considered to...
M. Steven Oberste, Mohammed M. Feeroz, Kaija Maher, W. Allan Nix et al.
The term synanthropic describes organisms that thrive in human-altered habitats. Where synanthropic nonhuman primates (NHP) share an ecological niche with humans, cross-species transmission of infectious agents can occur. In Bangladesh, synanthropic NHP are found in villages, densely populated citie...
Mustafizur Rahman, Jelle Matthijnssens, Truus Goegebuer, Karolien De Leener et al.
Background Group A rotavirus genotypes G1, G2, G3 and G4 are the main etiological agents of infantile diarrhea. The G9 rotavirus has recently emerged as a fifth important genotype all over the world. Objective To characterize the VP7 gene of group A rotaviruses from gastroenteritis patients admitted...
Jelle Matthijnssens, Mustafizur Rahman, Marc Van Ranst
In 2003, we described the first human G6P[6] rotavirus strain (B1711). To investigate further the molecular origin of this strain and to determine the possible reassortments leading to this new gene constellation, the complete genome of strain B1711 was sequenced. SimPlot analyses were conducted to ...
K Jarecki-Khan, Saul Tzipori, Leanne Unicomb
A total of 4,409 stool specimens from infants less than 5 years of age seeking treatment for diarrhea in Matlab, Bangladesh, were tested for the presence of adenoviruses by using an enzyme immunoassay (EIA). EIA-positive stool samples were serotyped with monoclonal antibodies specific for adenovirus...