B Ogunkolade, Barbara J. Boucher, Jean M. Prahl, Stephen A. Bustin et al.
Associations have been reported between vitamin D receptor (VDR) gene polymorphisms, type 1 diabetes, insulin secretion, and the insulin resistance syndrome. As VDR polymorphisms have no known functional significance, these findings may implicate a variant of the VDR gene or a locus in linkage diseq...
G. A. Hitman, Nasima Mannan, Michael McDermott, E Aganna et al.
Nasima Mannan, Barbara J. Boucher, Stephen Evans
Type 2 diabetes is commoner in Asians than Caucasians. Many nitrosamines are diabetogenic, causing both type 2 and type 1 diabetes. Of CD1 mice fed with betel-nut or associated nitrosamines 8.5% develop glucose intolerance with marked obesity. Glycaemia and anthropometric risk markers for type 2 dia...
W. Garry John, Kate Noonan, Nasima Mannan, Barbara J. Boucher
W Ogunkolade, Barbara J. Boucher, Stephen A. Bustin, Jacky M. Burrin et al.
CONTEXT: Vitamin D deficiency, common in South Asians, is a risk factor for metabolic syndrome, type 2 diabetes, and ischemic heart disease. Vitamin D receptor (VDR) activation depends on activated vitamin D [1,25-dihydroxyvitamin D (1,25(OH)(2)D)] concentration, reflecting opposing actions of 25-hy...
W. Garry John, Kate Noonan, Nasima Mannan, Barbara J. Boucher
Background Although hypovitaminosis D has been suggested to increase the risk of heart disease, its relation to components of the fasting lipid profile has not been clarified for specific ethnic groups. Objective The objective was to determine the relation of circulating 25-hydroxyvitamin D [25(OH)D...
OA Obeid, Nasima Mannan, Gilbert J. Perry, RA Iles et al.
Barbara J. Boucher
Merchant and his colleagues use tertiles of paan-years in their analysis of the increased odds ratios for risk of oral cancer in those using betel nut (Areca catechu) with, or without, the addition of tobacco to the leaf-wrapped quids.1 Because these findings are of considerable inportance for healt...
Barbara J. Boucher
Barbara J. Boucher
Sir, I found the paper ‘Lower risk for cardiovascular mortality in oral 1a-hydroxy vitamin D3 users in a haemodialysis population’ of great interest [1]. We have found a reduction in levels of the inflammatory risk markers for cardiovascular disease, sCRP, MMP2 and most especially of MMP9, in appare...
Kajus Merkevičius, Dmitrii Smirnov, Lea D. Schlieben, Rebecca Ganetzky et al.
This retrospective study on X-linked PDHA1-related pyruvate dehydrogenase complex (PDHc) deficiency combined a systematic literature review with a multicenter survey exploring genotypes, phenotypes, and survival. Data from 891 individuals (45% unpublished) were included. Of note, 53% of cases were f...
G. A. Hitman, W Ogunkolade, Stephen A. Bustin, J. M. Burrin et al.
Barbara J. Boucher, Nasima Mannan, OA Obeid, H. D. Murphy et al.
Conference Abstract| August 01 1998 Increased Prevalence of Raised Serum Homocysteine in Bangladeshis in the Uk BJ Boucher; BJ Boucher 3St Bartholomews & Royal London MDS, Queen Mary & Westfield Colige, London Search for other works by this author on: This Site PubMed Google Scholar N Mannan; N Mann...