David F. Choy, Kevin M. Hart, Lee A. Borthwick, Aarti Shikotra et al.
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), endobronchial tissue gene expression analysis revealed three major patient clusters: TH2-high, TH17-high, and TH2/17...
Lorcan McGarvey, Claire A. Butler, Susan Stokesberry, Liam Polley et al.
Background The airway epithelium is exposed to a range of physical and chemical irritants in the environment that are known to trigger asthma. Transient receptor potential (TRP) cation channels play a central role in sensory responses to noxious physical and chemical stimuli. Recent genetic evidence...
Joseph R. Arron, David F. Choy, Michel Laviolette, Steven G. Kelsen et al.
To the Editor: Asthma heterogeneity has been described by the nature and intensity of granulocytic infiltration into the airways [1, 2]. Sputum, endobronchial biopsies and bronchoalveolar lavage (BAL) sample different anatomical regions of the airways. Few studies have directly compared the inflamma...
Emma Doran, David F. Choy, Aarti Shikotra, Claire A. Butler et al.
Severe asthma represents a major unmet clinical need. Eosinophilic inflammation persists in the airways of many patients with uncontrolled asthma, despite high-dose inhaled corticosteroid therapy. Suppressors of cytokine signalling (SOCS) are a family of molecules involved in the regulation of cytok...
Ellen Rafferty, Janna M. Schurer, Michael B. Arndt, Robert K. M. Choy et al.
Cryptosporidium is a leading cause of pediatric diarrhea in resource-limited settings; yet, few studies report the health care costs or societal impacts of this protozoan parasite. Our study examined direct and indirect costs associated with symptomatic cryptosporidiosis in infants younger than 12 m...
Joshua M. Ackerman, Theodore Samore, Daniel M. T. Fessler, Tom R. Kupfer et al.
Identifying cues to contagious disease is critical for effectively tracking and defending against interpersonal infection threats. People hold lay beliefs about the types of sensory information most relevant for identifying whether others are sick with transmissible illnesses. Are these beliefs univ...
Aarti Shikotra, David F. Choy, Salman Siddiqui, Greer Arthur et al.
<b>Background:</b> Understanding the pathophysiology of severe asthma is essential for the development of novel therapies. Carcinoembryonic antigen cell adhesion molecule (CEACAM) family members are expressed in healthy lung tissue, and have properties that suggest they may play a role in asthma pat...
Ernest Choy, Beverley White-Alao, Fowzia Ibrahim, Anna Kowalczyk et al.
D. Mulherin, Oliver FitzGerald, Barry Bresnihan, G. Yanni et al.