Edwin J. C. G. van den Oord, Patrick F. Sulli, Yuxin Jiang, Dermot Walsh et al.
A recent report showed significant associations between several SNPs in a previously unknown EST cluster with schizophrenia. (1). The cluster was identified as the human dystrobrevin binding protein 1 gene (DTNBP1) by sequence database comparisons and homology with mouse DTNBP1. (2). However, the li...
Vladimir I. Vladimirov, Dawn L. Thiselton, P-H Kuo, Joseph L. McClay et al.
The TAAR6 gene has been previously associated with schizophrenia in 192 pedigrees of European and African ancestry. To replicate these findings we performed an association study of TAAR6 in 265 pedigrees of the Irish Study of High-Density Schizophrenia Families (ISHDSF). Of the 24 genotyped single-n...
Joseph L. McClay, Ayman H. Fanous, Edwin J. C. G. van den Oord, Bradley T. Webb et al.
A functional polymorphism (Val-158-Met) at the Catechol-O-methyltransferase (COMT) locus has been identified as a potential etiological factor in schizophrenia. Yet the association has not been convincingly replicated across independent samples. We hypothesized that phenotypic heterogeneity might be...