Jelle Matthijnssens, Elisabeth Heylen, Mark Zeller, Mohammad Mustafizur Rahman et al.
Rotaviruses (RVs) are responsible for more than 600,000 child deaths each year. The worldwide introduction of two life oral vaccines RotaTeq and Rotarix is believed to reduce this number significantly. Before the licensing of both vaccines, two new genotypes, G9 and G12, emerged in the human populat...
Mark Zeller, Mustafizur Rahman, Elisabeth Heylen, Sarah De Coster et al.
Rotarix™ was introduced into the Belgian market in 2006 and RotaTeq™ in 2007, quickly reaching more than 85% vaccine coverage of all newborns in Belgium. The incidence of rotavirus gastroenteritis has been monitored in the Gasthuisberg University Hospital (GUH), Belgium since 1986, and since 1999 th...
Jelle Matthijnssens, Mustafizur Rahman, Max Ciarlet, Mark Zeller et al.
G11 rotaviruses are believed to be of porcine origin. However, a limited number of G11 rotaviruses have been recently isolated from humans in combination with P[25], P[8], P[6], and P[4]. To investigate the evolutionary relationships of these strains, we analyzed the complete genomes of 2 human G11P...
Mustafizur Rahman, Jelle Matthijnssens, Farjana Saiada, Zahid Hassan et al.
More than 120 variants of rotavirus strains with different VP7 (G type) and VP4 (P type) combinations are reported thus far. Among them Wa-like G1P[8] rotaviruses are the most common human strains worldwide. However, characterization of their entire genome complement is limited to a few old prototyp...
Elisabeth Heylen, Mark Zeller, Max Ciarlet, Jody Lawrence et al.
BACKGROUND: P[6] rotaviruses have been circulating with a high prevalence in African and, to a more limited extent, Asian countries, but they have not been highly prevalent in other parts of the world. METHODS: To investigate the genomic relationship between African and Asian human P[6] rotaviruses ...