Taibur Rahman, Md. Ismail Hosen, Md. Monirul Islam, Hossain Uddin Shekhar
Redox degenerative reactions of the biological system inevitably produce reactive oxygen species (ROS) and their derivatives. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species (ROS), such as hydrogen pe...
Sajib Chakraborty, Md. Ismail Hosen, Musaddeque Ahmed, Hossain Uddin Shekhar
The acquisition of cancer hallmarks requires molecular alterations at multiple levels including genome, epigenome, transcriptome, proteome, and metabolome. In the past decade, numerous attempts have been made to untangle the molecular mechanisms of carcinogenesis involving single OMICS approaches su...
Q. Shazia, Zamani Mohammad, Taibur Rahman, Hossain Uddin Shekhar
Beta thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival. This may cause oxidative stress and tissue injury due to iron overload, altered antioxidant enzymes, and other essenti...
Md. Ismail, Md. Faruk Hossain, Arifur Rahman Tanu, Hossain Uddin Shekhar
BACKGROUND AND OBJECTIVE: Oxidative stress is intimately associated with many diseases, including chronic obstructive pulmonary disease (COPD). Study objectives include a comparison of the oxidative stress, antioxidant status, and lipid profile between COPD patients and controls and evaluation of th...
Masashi Kato, Mayuko Y. Kumasaka, S. Ohnuma, Akio Furuta et al.
Health risk for well drinking water is a worldwide problem. Our recent studies showed increased toxicity by exposure to barium alone (≤700 µg/L) and coexposure to barium (137 µg/L) and arsenic (225 µg/L). The present edition of WHO health-based guidelines for drinking water revised in 2011 has maint...
Farjana Akther Noor, Nusrat Sultana, Golam Sarower Bhuyan, Md Tarikul Islam et al.
BACKGROUND: ß-thalassemia is one of the most common inherited blood disorders in the world and a major deterrent to the public health of Bangladesh. The management of thalassemia patients requires lifelong frequent blood transfusion and the available treatment options are unsatisfactory. A national ...
Md. Fazlul Karim, Md. Ismail, A M Mahmudul Hasan, Hossain Uddin Shekhar
BACKGROUND: Thalassemia is one of the most common hereditary disorders and Beta-thalassemia major is its severe form. The present study is concerned with the analysis of liver function, thyroid function and estimation of critical serum ions as well as hematological characteristics in beta-thalassemi...
Mayuko Y. Kumasaka, Osamu Yamanoshita, Shingo Shimizu, S. Ohnuma et al.
Various carcinomas including skin cancer are explosively increasing in arsenicosis patients who drink arsenic-polluted well water, especially in Bangladesh. Although well drinking water in the cancer-prone areas contains various elements, very little is known about the effects of elements except ars...
Ichiro Yajima, Noriyuki Uemura, Saika Nizam, Md. Khalequzzaman et al.
Our fieldwork showed more than 1 μM (145.1 μg/L) barium in about 3 μM (210.7 μg/L) arsenic-polluted drinking well water (n = 72) in cancer-prone areas in Bangladesh, while the mean concentrations of nine other elements in the water were less than 3 μg/L. The types of cancer include squamous cell car...
Ar-Rafi Md. Faisal, Syed Hassan Imtiaz, Tasnim Zerin, Tania Rahman et al.
Ymr210w was identified as a MAG (Monoacylglycerol) lipase. The accumulation of the phospholipids in the ymr210wΔ was not clearly understood. It was expressed in S. cerevisiae using pYES2/CT vector and His-tag purified recombinant protein confirmed TAG lipase activity. To further evaluate the role of...
Sharif A. Mukul, Shekhar R. Biswas, A. Z. M. Manzoor Rashid, Md. Danesh Mıah et al.
In tropical developing countries, reducing emissions from deforestation and forest degradation (REDD+) is becoming an important mechanism for conserving forests and protecting biodiversity. A key prerequisite for any successful REDD+ project, however, is obtaining baseline estimates of carbon in for...
Md Tarikul Islam, Suprovath Kumar Sarkar, Nusrat Sultana, Mst. Noorjahan Begum et al.
BACKGROUND: Bangladesh lies in the global thalassemia belt, which has a defined mutational hot-spot in the beta-globin gene. The high carrier frequencies of beta-thalassemia trait and hemoglobin E-trait in Bangladesh necessitate a reliable DNA-based carrier screening approach that could supplement t...
Ichiro Yajima, Mayuko Y. Kumasaka, S. Ohnuma, Nobutaka Ohgami et al.
Various cancers including skin cancer are increasing in 45 million people exposed to arsenic above the World Health Organization's guideline value of 10 μg l(-1). However, there is limited information on key molecules regulating arsenic-mediated carcinogenesis. Our fieldwork in Bangladesh demonstrat...
Yearul Kabir, Hossain Uddin Shekhar, Jiwan S. Sidhu
Mango (Mangifera indica L.), which belongs to the family Anacardiaceae, is a rich source of various bioactive phytochemical compounds. This chapter provides a brief description of various functional properties and health benefits of bioactive compounds found in mango. Mango polyphenols, like other p...
Shamima Akter, Hossain Uddin Shekhar, Sharif Akhteruzzaman
Background: The liver function tests (LFTs) remain one of the most commonly employed clinical measures for the diagnosis of hepatobiliary disease. LFTs sometimes referred to as hepatic panel help to determine the health of liver, monitor the progression of a disease and measure the severity of a dis...