Afroza Akter, Tasnuva Ahmed, Imam Tauheed, Marjahan Akhtar et al.
BACKGROUND: COVID-19 caused by SARS-CoV-2 ranges from asymptomatic to severe disease and can cause fatal and devastating outcome in many cases. In this study, we have compared the clinical, biochemical and immunological parameters across the different disease spectrum of COVID-19 in Bangladeshi pati...
Marjahan Akhtar, Md. Rashedul Islam, Fatema Khaton, Umma Hany Soltana et al.
Background: Understanding the characteristics of the humoral immune responses following COVID-19 vaccinations is crucial for refining vaccination strategies and predicting immune responses to emerging SARS-CoV-2 variants. Methods: A longitudinal analysis of SARS-CoV-2 spike receptor binding domain (...
Imam Tauheed, Tasnuva Ahmed, Afroza Akter, Md Golam Firoj et al.
Background Enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae O1 are most common bacterial causes of diarrheal diseases in Bangladesh. This analysis projected distribution of ETEC and V. cholerae O1 among diarrheal patients of icddr,b, Dhaka hospital in two diarrheal peaks of 2022. Methodol...
Fahima Chowdhury, Taufiqur Rahman Bhuiyan, Afroza Akter, Md Saruar Bhuiyan et al.
We have earlier reported that a single dose of oral cholera vaccine (OCV) is protective in adults and children ≥5 years of age and sustained for 2 years. We enrolled participants (n = 240) from this study, between March-September 2017, over 3 years after receiving a primary single dose. Immune respo...
Fahima Chowdhury, Khalid Syed, Afroza Akter, Taufiqur Rahman Bhuiyan et al.
BACKGROUND: The World Health Organization (WHO) recommends the use of oral cholera vaccines (OCVs) as part of an integrated control program, both in highly endemic settings and during cholera epidemics. The available and internationally recommended WHO-prequalified OCVs (Dukoral, Shanchol, Euvichol)...
Marjahan Akhtar, Yasmin Ara Begum, Sadia Rahman, Mokibul Hassan Afrad et al.
Background Age plays a significant role in susceptibility to enterotoxigenic Escherichia coli (ETEC) infections, yet the distribution of ETEC virulence factors across age groups remains understudied. This study investigated the differential pathogenic profiles ETEC across various age groups, emphasi...
Pinki Dash, Al Hakim, Aklima Akter, Hasan Al Banna et al.
ABSTRACT Vaccination is important to prevent cholera. There are limited data comparing anti-O-specific polysaccharide (OSP) and anti-cholera toxin-specific immune responses following oral whole-cell with cholera toxin B-subunit (WC-rBS) vaccine (Dukoral, Valneva) administration in different age grou...
Farhana Khanam, Md Taufiqul Islam, Faisal Ahmmed, Shams Uddin Ahmed et al.
Background: From May to December 2021, Bangladesh experienced a major surge in the Delta variant of SARS-CoV-2. The earlier rollout of several vaccines offered the opportunity to evaluate vaccine effectiveness against this variant. Methods: A prospective, test-negative case-control study was conduct...
Fahima Chowdhury, Afroza Akter, Taufiqur Rahman Bhuiyan, Imam Tauheed et al.
Bangladesh remains cholera endemic with biannual seasonal peaks causing epidemics. At least 300,000 severe cases and over 4,500 deaths occur each year. The available oral cholera vaccineshave not yet been adopted for cholera control in Bangladesh due to insufficient number of doses available for end...
Marjahan Akhtar, Salima Raiyan Basher, Nuder Nower Nizam, Mohammad Kamruzzaman et al.
The longevity of immune responses induced by different degrees of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection provides information important to understanding protection against coronavirus disease 2019 (COVID-19). Here, we report the persistence of SARS-CoV-2 spike recepto...
Taufiqur Rahman Bhuiyan, Hasan Al Banna, M. Hasanul Kaisar, Polash Chandra Karmakar et al.
Coronavirus disease 2019 (COVID-19) is a protean disease causing different degrees of clinical severity including fatality. In addition to humoral immunity, antigen-specific T cells may play a critical role in defining the protective immune response against SARS-CoV-2, the virus that causes this dis...
Fahima Chowdhury, Taufiqur Rahman Bhuiyan, Afroza Akter, Md Saruar Bhuiyan et al.
After the large influx of Rohingya nationals (termed Forcibly Displaced Myanmar National; FDMN) from Rakhine State of Myanmar to Cox's Bazar in Bangladesh, it was apparent that outbreaks of cholera was very likely in this setting where people were living under adverse water and sanitation conditions...
Fahima Chowdhury, Afroza Akter, Taufiqur Rahman Bhuiyan, Imam Tauheed et al.
Worldwide Hepatitis B is known as one of the imperative causes of mortality and morbidity as well as occupational health hazard among health workers. Bangladesh is intermediate endemic country for Hepatitis B infection for which the government has introduced hepatitis B vaccination into the Expanded...
Marjahan Akhtar, Md. Rashedul Islam, Fatema Khaton, Fatima Rahman et al.
Background: Both SARS-CoV-2 infection and COVID-19 vaccines elicit immunological responses. However, it is difficult to distinguish responses generated after vaccination versus natural infection. Methods: We investigated SARS-CoV-2 spike receptor-binding domain (RBD) and nucleocapsid-specific IgG an...
Sadia Rahman, Mohammad Jubair, Marjahan Akhtar, Afroza Akter et al.
(ETEC), a leading cause of diarrhea, is defined by heat-stable (ST) and/or heat-labile (LT) toxins and associated colonization factors (CFs). However, there is still a knowledge gap in understanding ETEC's evolution, particularly in endemic regions like Bangladesh. This study investigates the genomi...
Tasnuva Ahmed, Imam Tauheed, Shahinur Hoque, Golam Sarower Bhuyan et al.
Meningococcal disease is caused by Neisseria meningitidis or meningococcus. Every year globally around 1.2 million people are affected and approximately 120,000 deaths occur due to meningitis. The disease can be prevented by a single dose of meningococcal vaccine. We carried out a randomized observe...
Fahima Chowdhury, Afroza Akter, Taufiqur Rahman Bhuiyan, Rajib Biswas et al.
Background: Immune responses that target sialidase occur following natural cholera and have been associated with protection against cholera. Sialidase is a neuraminidase that facilitates the binding of cholera toxin (CT) to intestinal epithelial cells. Despite this, little is known about age-related...
Md Taufiqul Islam, Ashraful Islam Khan, Zahid Hasan Khan, Nabid Anjum Tanvir et al.
Objective Cholera poses a substantial public health challenge in most developing nations, including Bangladesh. In cholera-endemic settings, optimizing vaccine utilization is crucial to prevent wastage and strengthen outbreak preparedness. This study demonstrates an innovative approach to repurposin...
Marjahan Akhtar, Md. Rashedul Islam, Zahid Hasan Khan, Afroza Akter et al.
Background: The dynamics of humoral immune responses following primary and booster COVID-19 vaccinations are crucial to understand in order to optimize vaccination strategies. This study evaluates the magnitude and durability of SARS-CoV-2-specific IgG antibody responses across different vaccines in...
Md Taufiqul Islam, Ashraful Islam Khan, Zahid Hasan Khan, Nabid Anjum Tanvir et al.
Objective Cholera poses a substantial public health challenge in most developing nations, including Bangladesh. In cholera-endemic settings, optimizing vaccine utilization is crucial to prevent wastage and strengthen outbreak preparedness. This study demonstrates an innovative approach to repurposin...