Mihai Pop, Alan W. Walker, Joseph N. Paulson, Brianna Lindsay et al.
BACKGROUND: Diarrheal diseases continue to contribute significantly to morbidity and mortality in infants and young children in developing countries. There is an urgent need to better understand the contributions of novel, potentially uncultured, diarrheal pathogens to severe diarrheal disease, as w...
Brianna Lindsay, Joe Oundo, M. Anowar Hossain, Martín Antonio et al.
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 ...
Brianna Lindsay, Mihai Pop, Martín Antonio, Alan W. Walker et al.
Cultivation-based assays combined with PCR or enzyme-linked immunosorbent assay (ELISA)-based methods for finding virulence factors are standard methods for detecting bacterial pathogens in stools; however, with emerging molecular technologies, new methods have become available. The aim of this stud...
Joseph N. Paulson
High-throughput technologies such as whole targeted sequencing of marker-genes and whole metagenomic shotgun (WMS) sequencing have provided unprecedented insight into microbial communities and the interactions between their members. Statistical inference is a challenging task in analyzing these comm...