Mohammad H. Forouzanfar, Ashkan Afshin, Lily Alexander, H Ross Anderson et al.
BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debat...
Derek Klarin, The VA Million Veteran Program, Scott M. Damrauer, Kelly Cho et al.
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical...
Norihiro Kato, CARDIo GRAMplusCD, LifeLines Cohort Study, Marie Loh et al.
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). ...
Yanjun Cai, Inez Fung, R. Lawrence Edwards, Zhisheng An et al.
A speleothem δ(18)O record from Xiaobailong cave in southwest China characterizes changes in summer monsoon precipitation in Northeastern India, the Himalayan foothills, Bangladesh, and northern Indochina over the last 252 kyr. This record is dominated by 23-kyr precessional cycles punctuated by pro...
Helen E. Gruber, Tracy Johnson, Kelly Leslie, Jane A. Ingram et al.
STUDY DESIGN: Work presented here used a small animal model to illustrate the feasibility of autologous disc cell implantation. OBJECTIVES: To develop a small animal model for autologous disc cell implantation. SUMMARY OF THE BACKGROUND DATA: The use of autologous disc cells in the potential treatme...
V. Spike Peterson
Click to increase image sizeClick to decrease image size Acknowledgments I am grateful to Georgina Waylen for her generosity in sharing prepublication work with me; and to Drucilla Barker, Jen Cohen, Deb Figart, Ellen Mutari, Julie Nelson, Paulette Olsen and Ara Wilson for conference discussions reg...
Derek Klarin, Shefali S. Verma, Renae Judy, Ozan Dikilitas et al.
Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction of AAA heritability. Methods: We performed a genome-wide association stu...
Claire Palles, Laura Chegwidden, Xinzhong Li, John M. Findlay et al.
BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subse...
Yan Boucher, Otto X. Cordero, Alison Takemura, Dana E. Hunt et al.
Vibrio cholerae represents both an environmental pathogen and a widely distributed microbial species comprised of closely related strains occurring in the tropical to temperate coastal ocean across the globe (Colwell RR, Science 274:2025-2031, 1996; Griffith DC, Kelly-Hope LA, Miller MA, Am. J. Trop...
Molly K. Grace, H. Reşi̇t Akçakaya, Elizabeth L. Bennett, Thomas M. Brooks et al.
Recognizing the imperative to evaluate species recovery and conservation impact, in 2012 the International Union for Conservation of Nature (IUCN) called for development of a "Green List of Species" (now the IUCN Green Status of Species). A draft Green Status framework for assessing species' progres...
Russell A. Johnson, Taher Uddin, Amena Aktar, M. Mohasin et al.
Immunity against Vibrio cholerae O1 is serogroup specific, and serogrouping is defined by the O-specific polysaccharide (OSP) part of lipopolysaccharide (LPS). Despite this, human immune responses to V. cholerae OSP have not previously been characterized. We assessed immune responses against V. chol...
Robert C. Kauffman, Taufiqur Rahman Bhuiyan, Rie Nakajima, Leslie M. Mayo-Smith et al.
We characterized the acute B cell response in adults with cholera by analyzing the repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. We found that the cholera-induced responses were characterized by high levels...
Mohammad Kamruzzaman, Shahriar Wahid, Shamsuddin Shahid, Edris Alam et al.
Understanding spatiotemporal variability in precipitation and temperature and their future projections is critical for assessing environmental hazards and planning long-term mitigation and adaptation. In this study, 18 Global Climate Models (GCMs) from the most recent Coupled Model Intercomparison P...
Md. Abu Sayeed, Meagan Kelly Bufano, Peng Xu, Grace Eckhoff et al.
BACKGROUND: Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). METHODOLOGY: Here we describe a conjugate vaccine for choler...
Amresh Chopdar, Usha Chakravarthy, Dinesh Verma
EDITOR—Kelly et al point out that we did not discuss the importance of smoking as a risk factor. Our article was intended to provide a broad yet brief perspective on age related macular degeneration, and with the constraints on space we were unable to provide specific and extensive details of the va...