Verónica Miguel, Jessica Tituaña, J. Ignacio Herrero, Laura Herrero et al.
Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent inflammatory and profibrotic response. Fatty acid oxidation (FAO), the main source of energy for TECs, is reduced in kidney fibrosis...
Martin Beal, Maria P. Dias, Richard A. Phillips, Steffen Oppel et al.
Migratory marine species cross political borders and enter the high seas, where the lack of an effective global management framework for biodiversity leaves them vulnerable to threats. Here, we combine 10,108 tracks from 5775 individual birds at 87 sites with data on breeding population sizes to est...
Abtin Tondar, Sergio Sánchez-Herrero, Asim Kumar Bepari, Amir Bahmani et al.
This study aimed to identify potential BCL-2 small molecule inhibitors using deep neural networks (DNN) and random forest (RF), algorithms as well as molecular docking and molecular dynamics (MD) simulations to screen a library of small molecules. The RF model classified 61% (2355/3867) of molecules...
Verónica Miguel, Jessica Tituaña, J.Ignacio Herrero, Laura Herrero et al.
Abstract Chronic kidney disease (CKD) remains a major epidemiological, clinical and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) suffer a persistent inflammatory and profibrotic response. Fatty acid oxidation (FAO), the main source of energy for TECs, is reduced in kidney ...
Abtin Tondar, Muhammad Irfan, Sergio Sánchez-Herrero, Hafsa Athar et al.
Non-synonymous single nucleotide polymorphisms (nsSNPs), also known as missense SNPs, can seriously affect an individual's vulnerability to numerous diseases, including cancer. In this study, we conducted a comprehensive in-silico analysis to examine the structural and functional implications of nsS...