Richelle C. Charles, Jason B. Harris, Michael R. Chase, Lauren M. Lebrun et al.
BACKGROUND: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic typhoidal illness in mice. The PhoP regulon is a well studied two component...
Regina C. LaRocque, Pardis C. Sabeti, Priya Duggal, Fahima Chowdhury et al.
Vibrio cholerae causes a dehydrating diarrheal illness that can be rapidly fatal in the absence of specific treatment. The organism is an historic scourge and, like similar infectious diseases, may have influenced the evolution of the human genome. We report here the results of the first candidate g...
Regina C. LaRocque, Bryan Krastins, Jason B. Harris, Lauren M. Lebrun et al.
An effective vaccine for Vibrio cholerae is not yet available for use in the developing world, where the burden of cholera disease is highest. Characterizing the proteins that are expressed by V. cholerae in the human host environment may provide insight into the pathogenesis of cholera and assist w...