Tanvir Mahtab Uddin, Arka Chakraborty, Ameer Khusro, BM Redwan Matin Zidan et al.
Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-molecular-weight bioactive agents have also been used for a variety of other medicinal applications. In the battle against microbes, antibiotics have certainly been a blessing to human civilization by savin...
Saikat Mitra, Mashia Subha Lami, Tanvir Mahtab Uddin, Rajib Das et al.
Plant-based phytochemicals are now being used to treat plenty of physiological diseases. Herbal drugs have gained popularity in recent years because of their strength, purity, and cheap cost-effectiveness. Citrus fruits contain significant amounts of flavanones, which falls to the category of polyph...
Arka Chakraborty, Tanvir Mahtab Uddin, B. M. Redwan Matin Zidan, Saikat Mitra et al.
As Allium cepa is one of the most important condiment plants grown and consumed all over the world, various therapeutic and pharmacological effects of A. cepa were reviewed. Onion (Allium cepa) is a high dietary fiber-rich perennial herb that is placed under the family Amaryllidaceae. It contains hi...
Rapeephan R. Maude, Md. Amir Hossain, Mahtab Uddin Hassan, Sophie Osbourne et al.
INTRODUCTION: Measurement of optic nerve sheath diameter (ONSD) by ultrasound is increasingly used as a marker to detect raised intracranial pressure (ICP). ONSD varies with age and there is no clear consensus between studies for an upper limit of normal. Knowledge of normal ONSD in a healthy popula...
Quique Bassat, Dianna M. Blau, Ikechukwu U. Ogbuanu, Solomon Samura et al.
Importance: The number of deaths of children younger than 5 years has been steadily decreasing worldwide, from more than 17 million annual deaths in the 1970s to an estimated 5.3 million in 2019 (with 2.8 million deaths occurring in those aged 1-59 months [53% of all deaths in children aged <5 years...
Md. Sajib Al Reza, Md. Mahmudul Hasan, Md. Kamruzzaman, Md. Imam Hossain et al.
Abstract This study was conducted to evaluate the toxic effects of an azo dye carmoisine widely used in foods and to investigate its relation to carcinogenicity. Carmoisine administered into mice orally in four different doses as control, low, medium, and high equivalent to 0, 4, 200, and 400 mg/kg ...
Katherine Plewes, Hugh W. F. Kingston, Aniruddha Ghose, Richard J. Maude et al.
Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown. As part of a prospective observational study, enrolment plasma cell-free hemo...
Josh Hanson, Sue J. Lee, Md Amir Hossain, Nicholas M. Anstey et al.
BACKGROUND: Microvascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease's pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe falcip...
Richard J. Maude, Nicholas A. V. Beare, Abdullah Abu Sayeed, Christina C. Chang et al.
A specific retinopathy has been described in African children with cerebral malaria, but in adults this has not been extensively studied. Since the structure and function of the retinal vasculature greatly resembles the cerebral vasculature, study of retinal changes can reveal insights into the path...
Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy et al.
persists in the circulation of artesunate-treated malaria patients in Bangladesh and in French travelers who became infected with malaria in Africa. HRP2 persisted in whole blood (not plasma) of artesunate-treated patients with malaria at higher levels compared to quinine-treated patients. Using an ...
Katherine Plewes, Hugh W. F. Kingston, Aniruddha Ghose, Thanaporn Wattanakul et al.
Background: Acute kidney injury independently predicts mortality in falciparum malaria. It is unknown whether acetaminophen's capacity to inhibit plasma hemoglobin-mediated oxidation is renoprotective in severe malaria. Methods: This phase 2, open-label, randomized controlled trial conducted at two ...
Katherine Plewes, A. A. N. M. Royakkers, Josh Hanson, Md Mahtab Uddin Hasan et al.
BACKGROUND: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The precise pathophysiology of AKI in falciparum malaria remains unclear. Histopatholog...
Mamun Al‐Mahtab, Sheikh Mohammad Fazle Akbar, Julio Aguilar, Md. Helal Uddin et al.
Purpose The safety and clinical efficacy of a vaccine containing both hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) (HBsAg/HBcAg) were evaluated in patients with chronic hepatitis B (CHB). Methods Eighteen patients with CHB were administered a vaccine containing 100 μg of ...
Zachary J. Madewell, Cynthia G. Whitney, Sithembiso Velaphi, Portia Mutevedzi et al.
Importance: Although child mortality trends have decreased worldwide, deaths among children younger than 5 years of age remain high and disproportionately circumscribed to sub-Saharan Africa and Southern Asia. Tailored and innovative approaches are needed to increase access, coverage, and quality of...
Josh Hanson, Nguyen Hoan Phu, Mahtab Uddin Hasan, Prakaykaew Charunwatthana et al.
BACKGROUND: Thrombocytopenia is a common finding in adults with severe falciparum malaria, but its clinical and prognostic utility is incompletely defined. METHODS: Clinical and laboratory data from 647 adults with severe falciparum malaria were analysed retrospectively to determine the relationship...