A.‐M. Svennerholm, Marianne Jertborn, I. e. Gothefors, Amr M. Karim et al.
Mucosal and systemic immune responses to a new oral cholera vaccine, consisting of the B subunit plus killed vibrios, were studied in Bangladeshi volunteers and compared with those to clinical cholera. A single peroral dose of vaccine induced a local IgA antitoxin response in intestinal-lavage fluid...
Marianne Jertborn, Ann‐Mari Svennerholm, Jan Holmgren
The possibility that antibody responses in serum, saliva, or breast milk samples to oral vaccines or enteric infections may reflect the intestinal immune response was evaluated in Bangladeshi volunteers orally immunized with a cholera B subunit-whole-cell vaccine (B + WCV) and in patients convalesci...
John D. Clemens, Bonita Stanton, J. Chakraborty, David A. Sack et al.
We conducted a randomized trial among persons in rural Bangladesh to evaluate the side effects and immunogenicity of orally administered B subunit-killed whole cell (BS-WC) and killed whole cell-only (WC) cholera vaccines and a killed Escherichia coli strain K12 placebo proposed for field testing. T...
Jan Holmgren, Ann‐Mari Svennerholm, Marianne Jertborn, John D. Clemens et al.
During the last decade there has been a rapid progress in the development of new, much improved vaccines against cholera. These vaccines, which are given orally to stimulate the gut mucosal immune system, are based on either a combination of purified cholera toxin B (binding) subunit and killed chol...
John D. Clemens, Marianne Jertborn, David A. Sack, Bonita Stanton et al.
Journal Article Effect of Neutralization of Gastric Acid on Immune Responses to an Oral B Subunit, Killed Whole-Cell Cholera Vaccine Get access J. D. Clemens, J. D. Clemens International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; the University of Göteborg, Göteborg, Swed...
Marianne Jertborn, A.‐M. Svennerholm, Jan Holmgren
The immunoglobulin subclass distribution of cholera antitoxin antibody responses in serum was studied in Swedish volunteers after different routes of immunization with a cholera B subunit-whole cell vaccine (B + WCV) and in Bangladeshi patients convalescing from cholera disease. Both oral and parent...
Jan Holmgren, A.‐M. Svennerholm, Leif Gothefors, Marianne Jertborn et al.
We examined whether infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-labile enterotoxin (LT) can prime the gut immune system to respond more efficiently to the immunologically related cholera B subunit component of a recently developed oral B subunit-whole-cell cholera vacci...
Firdausi Qadri, Muhammad Asaduzzaman, Christine Wennerås, Golam Mohi et al.
Cholera toxin (CT)-specific antibody responses of the immunoglobulin E (IgE) isotype in the sera of adult patients suffering from infection with either Vibrio cholerae O1, V. cholerae O139, or enterotoxigenic Escherichia coli (ETEC) were analyzed and compared with those in the sera of volunteers imm...
A.‐M. Svennerholm, Marianne Jertborn, Leif Gothefors, A. Karim et al.
Purified B subunit of cholera toxin retains membrane-binding capacity and protective immunogenicity and yet has no toxic activity as tested in animals. These properties suggest that B subunit might be a promising immunogen, particularly as an oral vaccine, for stimulating protective antitoxic immuni...
A-M Svennerholm, Marianne Jertborn, Leif Gothefors, Amr M. Karim et al.