Marie Ng, Tom Fleming, Margaret S. Robinson, Blake Thomson et al.
Background In 2010, overweight and obesity were estimated to cause 3.4 million deaths, 3.9% of years of life lost, and 3.8% of DALYs globally. The rise in obesity has led to widespread calls for regular monitoring of changes in overweight and obesity prevalence in all populations. Comparative, up-to...
Elizabeth A. Ashley, Mehul Dhorda, Rick M. Fairhurst, Chanaki Amaratunga et al.
BACKGROUND: Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistance is essential for planning containment and elimination strategies. METHODS: Between May 2011 and Apri...
Olivo Miotto, Roberto Amato, Elizabeth A. Ashley, Bronwyn MacInnis et al.
We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains, ...
Sachel Mok, Elizabeth A. Ashley, Pedro Eduardo Ferreira, Lei Zhu et al.
Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of...
Norihiro Kato, CARDIo GRAMplusCD, LifeLines Cohort Study, Marie Loh et al.
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). ...
Kathryn E. Lafond, Harish Nair, Mohammad Hafiz Rasooly, Fátima Valente et al.
BACKGROUND: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has be...
Rob W. van der Pluijm, Rupam Tripura, Richard M. Hoglund, Aung Pyae Phyo et al.
BACKGROUND: Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide eff...
Ali Disha, Saha Kuntal K., Nguyen Phuong H., Diressie Michael T. et al.
Household food insecurity (HFI) is a recognized underlying determinant of child undernutrition, but evidence of associations between HFI and child undernutrition is mixed. The purpose of this study was to investigate if HFI is associated with undernutrition in children aged 6-59.9 mo in Bangladesh (...
Phuong Hong Nguyen, Rasmi Avula, Marie T. Ruel, Kuntal Kumar Saha et al.
Dietary diversity (DD) reflects micronutrient adequacy of the diet and is associated with better child growth. Emerging evidence suggests that maternal and child DD are associated. This could have measurement and programmatic implications. Data on mother-child (6-24 mo) dyads in Bangladesh, Vietnam,...
Phuong Hong Nguyen, Sunny S. Kim, Tina Sanghvi, Zeba Mahmud et al.
Background: Maternal undernutrition is a major concern globally, contributing to poor birth outcomes. Limited evidence exists on delivering multiple interventions for maternal nutrition simultaneously. Alive & Thrive addressed this gap by integrating nutrition-focused interpersonal counseling, commu...
Purnima Menon, Phuong Hong Nguyen, Kuntal Kumar Saha, Khaled Adiba et al.
BACKGROUND: Complementary feeding (CF) contributes to child growth and development, but few CF programs are delivered at scale. Alive & Thrive addressed this in Bangladesh through intensified interpersonal counseling (IPC), mass media (MM), and community mobilization (CM). OBJECTIVE: The objective w...
Purnima Menon, Phuong Hong Nguyen, Kuntal Kumar Saha, Khaled Adiba et al.
BACKGROUND: Despite recommendations supporting optimal breastfeeding, the number of women practicing exclusive breastfeeding (EBF) remains low, and few interventions have demonstrated implementation and impact at scale. Alive & Thrive was implemented over a period of 6 y (2009-2014) and aimed to imp...
Christopher G. Jacob, Thuy-Nhien Nguyen, Mayfong Mayxay, Richard J. Maude et al.
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integ...
Jessica C. Stark, Ally Huang, Peter Q. Nguyen, Rachel S. Dubner et al.
Synthetic biology offers opportunities for experiential educational activities at the intersection of the life sciences, engineering, and design. However, implementation of hands-on biology activities in classrooms is challenging because of the need for specialized equipment and expertise to grow li...
Phuong Hong Nguyen, Kuntal Kumar Saha, Disha Ali, Purnima Menon et al.
OBJECTIVE: We assessed associations of maternal common mental disorders (CMD) with undernutrition and two common illnesses in children aged 0-5 years. DESIGN: Cross-sectional survey. Maternal CMD was measured using the WHO Self-Reporting Questionnaire-20. Child undernutrition was defined as stunting...