Ujjwal K. Chowdhury, Bhajan Kumar Biswas, Tarit Roy Chowdhury, Gautam Samanta et al.
Nine districts in West Bengal, India, and 42 districts in Bangladesh have arsenic levels in groundwater above the World Health Organization maximum permissible limit of 50 microg/L. The area and population of the 42 districts in Bangladesh and the 9 districts in West Bengal are 92,106 km(2) and 79.9...
Mohammad Mahmudur Rahman, Uttam Kumar Chowdhury, Subhash Chandra Mukherjee, Badal Kumar Mondal et al.
Fifty districts of Bangladesh and 9 districts in West Bengal, India have arsenic levels in groundwater above the World Health Organization's maximum permissible limit of 50 microg/L. The area and population of 50 districts of Bangladesh and 9 districts in West Bengal are 118,849 km2 and 104.9 millio...
Dipankar Chakraborti, Mohammad Mahmudur Rahman, Bhaskar Das, Matthew Murrill et al.
Since 1996, 52,202 water samples from hand tubewells were analyzed for arsenic (As) by flow injection hydride generation atomic absorption spectrometry (FI-HG-AAS) from all 64 districts of Bangladesh; 27.2% and 42.1% of the tubewells had As above 50 and 10 μg/l, respectively; 7.5% contained As above...
Linda Valeri, Maitreyi Mazumdar, Jennifer F. Bobb, Birgit Claus Henn et al.
BACKGROUND: Exposure to chemical mixtures is recognized as the real-life scenario in all populations, needing new statistical methods that can assess their complex effects. OBJECTIVES: We aimed to assess the joint effect of in utero exposure to arsenic, manganese, and lead on children's neurodevelop...
Mohammad Mahmudur Rahman, Debapriyo Mukherjee, Mrinal Kumar Sengupta, Uttam Kumar Chowdhury et al.
The exposure of millions to arsenic contaminated water from hand tube wells is a major concern in many Asiatic countries. Field kits are currently used to classify tube wells as delivering arsenic below 50 microg/L (the recommended limit in developing countries) as safe, painted green or above 50 mi...
Molly L. Kile, E. Andrés Houseman, Carrie V. Breton, Thomas J. Smith et al.
BACKGROUND: Millions of people in Bangladesh are at risk of chronic arsenic toxicity from drinking contaminated groundwater, but little is known about diet as an additional source of As exposure. METHODS: We employed a duplicate diet survey to quantify daily As intake in 47 women residing in Pabna, ...
Molly L. Kile, E. Andrés Houseman, Andrea Baccarelli, Quazi Quamruzzaman et al.
Prenatal arsenic exposure is associated with increased risk of disease in adulthood. This has led to considerable interest in arsenic's ability to disrupt fetal programming. Many studies report that arsenic exposure alters DNA methylation in whole blood but these studies did not adjust for cell mixt...
Molly L. Kile, Andrea Baccarelli, Elaine Hoffman, Letizia Tarantini et al.
BACKGROUND: Arsenic is an epigenetic toxicant and could influence fetal developmental programming. OBJECTIVES: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes. METHODS: Drinking-water and urine samples were collected when women were...
Ema Rodrigues, David C. Bellinger, Linda Valeri, Md Omar Sharif Ibne Hasan et al.
BACKGROUND: The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmen...
Karen L. Huyck, Molly L. Kile, Golam Mahiuddin, Quazi Quamruzzaman et al.
OBJECTIVE: To characterize the effects of maternal arsenic exposure on birth weight. METHODS: Hair, toenail, and drinking water samples were collected from pregnant women (n = 52) at multiple time points during pregnancy and from their newborns after birth. Total arsenic was measured using inductive...
Dipankar Chakraborti, Mohammad Mahmudur Rahman, Bhaskar Das, Bishwajit Nayak et al.
Wen‐Chi Pan, Wei Jie Seow, Molly L. Kile, Elaine Hoffman et al.
Chronic exposure to high levels of arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM), but the association between lower levels of arsenic and T2DM is more controversial. Therefore, this study evaluated the association between low to moderate arsenic expos...
Uttam Kumar Chowdhury, Mohammad Mahmudur Rahman, Mrinal Kumar Sengupta, Dilip Lodh et al.
Urinary arsenic is generally considered as the most reliable indicator of recent exposure to inorganic arsenic and is used as the main bio-marker of exposure. However, due to the different toxicity of arsenic compounds, speciation of arsenic in urine is generally considered to be more convenient for...
Molly L. Kile, Elaine Hoffman, Yu‐Mei Hsueh, Sakila Afroz et al.
BACKGROUND: Urinary arsenic metabolites (UAs) are used as biomarkers of exposure and metabolism. OBJECTIVES: To characterize inter- and intraindividual variability in UAs in healthy individuals. METHODS: In a longitudinal study conducted in Bangladesh, we collected water and spot urine samples from ...
Kathleen M. McCarty, Yen‐Ching Chen, Quazi Quamruzzaman, Mahmuder Rahman et al.
OBJECTIVE: We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. METHODS: A case-control study of 600 cases and 600 controls that were frequency matched on age and sex w...
Bhaskar Das, Mohammad Mahmudur Rahman, Bishwajit Nayak, Arup Pal et al.
Molly L. Kile, Andrés Cárdenas, Ema Rodrigues, Maitreyi Mazumdar et al.
BACKGROUND: The relationship between arsenic and birth weight is not well understood. The objective was to evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential mediation effects of gestational age and maternal weight gain during pregnancy usin...
Lindsay M. Jaacks, Nancy Diao, Antonia M. Calafat, María Ospina et al.
BACKGROUND: Pesticide exposure during pregnancy is thought to adversely affect fetal growth, which in turn may impact child growth, but results have been inconsistent across studies and few have explored these effects in developing countries. OBJECTIVES: To quantify urinary concentrations of pestici...
Selina Daisy, A K Mostaque, T S Bari, Attaullah Khan et al.
This prospective case-control study was conducted on 105 consecutive cases admitted to the burn units of Dhaka Shishu Hospital and Dhaka Medical College Hospital. The same number of controls were selected randomly from the community and matched with respect to age group, sex, and location of residen...
Ema Rodrigues, Molly L. Kile, Christine Dobson, Chitra Amarasiriwardena et al.
Because arsenic (As) and manganese (Mn) are able to pass the placenta, infants among exposed populations may be exposed to considerable levels in utero. The main objective of this paper is to evaluate infant toenails, hair, and cord blood as biomarkers of prenatal exposure to As and Mn and determine...