Cathryn M. Lewis, Douglas F. Levinson, Lesley H. Wise, Lynn E. DeLisi et al.
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkag To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to da...
Richard E. Straub, Yuxin Jiang, Charles J. MacLean, Yunlong Ma et al.
Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as well as results from several other samples, suggest that at least one such gene is located in region 6p24-21. In...
Richard E. Straub, C J MacLean, F. Anthony O’Neill, Dermot Walsh et al.
In our genome scan for schizophrenia genes in 265 Irish pedigrees, marker D5S818 in 5q22 produced the second best result of the first 223 markers tested (P = 0.002). We then tested an additional 13 markers and the evidence suggests the presence of a vulnerability locus for schizophrenia in region 5q...
Dieter B. Wildenauer, Sibylle G. Schwab, Margot Albus, Joachim Hallmayer et al.
In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403-567 informative pedigrees per marker, and in the Original sample which produced each finding (the Johns Hop...
Richard E. Straub, Charles J. MacLean, Rory Martin, Yunlong Ma et al.
In our genomic scan of 265 Irish families with schizophrenia, we have thus far generated modest evidence for the presence of vulnerability genes in three chromosomal regions, i.e., 5q21-q31, 6p24-p22, and 8p22-p21. Outside of those regions, of all markers tested to date, D10S674 produced one of the ...
Richard E. Straub, C J MacLean, Yunlong Ma, Bradley T. Webb et al.
From our linkage study of Irish families with a high density of schizophrenia, we have previously reported evidence for susceptibility genes in regions 5q21-31, 6p24-21, 8p22-21, and 10p15-p11. In this report, we describe the cumulative results from independent genome scans of three a priori random ...
Kenneth S. Kendler, F. Anthony O’Neill, John Burke, Bernadette Murphy et al.
Large samples of multiplex pedigrees will probably be needed to detect susceptibility loci for schizophrenia by linkage analysis. Standardized ascertainment of such pedigrees from culturally and ethnically homogeneous populations may improve the probability of detection and replication of linkage. T...
Kenneth S. Kendler, Charles J. MacLean, Yunlong Ma, F. Anthony O’Neill et al.
Linkage disequilibrium (LD) is a potentially powerful tool for the localization of disease genes for complex disorders. Most prior studies of the relationship between genetic distance and LD have examined only very short distances, focusing on the role of LD in fine-mapping and positional cloning. W...
Kenneth S. Kendler, F. Anthony O’Neill, John P. Burke, Bernadette Murphy et al.
Large samples of multiplex pedigrees will probably be needed to detect susceptibility loci for schizophrenia by linkage analysis. Standardized ascertainment of such pedigrees from culturally and ethnically homogeneous populations may improve the probability of detection and replication of linkage. T...