Results for “"Rumana Mahtarin"”

Sinthyia Ahmed, Rumana Mahtarin, Sayeda Samina Ahmed, Shaila Akter et al.

SARS-CoV-2 virus outbreak poses a major threat to humans worldwide due to its highly contagious nature. In this study, molecular docking, molecular dynamics, and structure-activity relationship are employed to assess the binding affinity and interaction of 76 prescription drugs against RNA dependent...

Sinthyia Ahmed, Rumana Mahtarin, Md. Shamiul Islam, Susmita Das et al.

trials against SARS-CoV-2.Communicated by Ramaswamy H. Sarma.

Mst. Noorjahan Begum, Rumana Mahtarin, Sinthyia Ahmed, Imrul Shahriar et al.

Congenital hypothyroidism is one of the most common preventable endocrine disorders associated with thyroid dysgenesis or dyshormonogenesis. Thyroid peroxidase (TPO) gene defect is mainly responsible for dyshormonogenesis; a defect in the thyroid hormone biosynthesis pathway. In Bangladesh, there is...

Mst. Noorjahan Begum, Rumana Mahtarin, Md Tarikul Islam, Sinthyia Ahmed et al.

The disorder of thyroid gland development or thyroid dysgenesis accounts for 80-85% of congenital hypothyroidism (CH) cases. Mutations in the TSHR gene are mostly associated with thyroid dysgenesis, and prevent or disrupt normal development of the gland. There is limited data available on the geneti...

Fatema- Tuz-Zohora, Rumana Mahtarin, Muhammad Ali, Mohammad Ariful Islam et al.

Phytochemical investigations of the methanolic extract of the whole plant of Micromelum minutum provided two coumarins, namely micromelin and murrangatin, and one sterol stigmast-4-en-3-one, the latter being reported for the first time from M. minutum. To evaluate bioactivities, different fractions ...

Raihan Rahman Imon, Sharmin Aktar, Niaz Morshed, Suza Mohammad Nur et al.

Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, has long been found to be dysregulated in human lung adenocarcinomas (LUADs). Nevertheless, the function, mutational profile, epigenetic regulation, co-expression profile, and clinicopathological significance of the GPC3 gene in LUAD ...

Mst. Noorjahan Begum, Rumana Mahtarin, Md Tarikul Islam, Nusrat Jahan Antora et al.

TPO (Thyroid Peroxidase) is known to be one of the major genes involved in congenital hypothyroid patients with thyroid dyshormonogenesis. The present study aims to validate high-resolution melting (HRM) curve analysis as a substitute method for Sanger sequencing, focusing on the frequently observed...

Mst. Noorjahan Begum, Rumana Mahtarin, Md Tarikul Islam, Sinthyia Ahmed et al.

Abstract The disorder of thyroid gland development or thyroid dysgenesis (TH) accounts for 80-85% cases of congenital hypothyroidism (CH). Hence, the understanding of molecular etiology of TH is prerequisite. Mutations in TSHR gene is mostly associated with thyroid dysgenesis, prevent or disrupt nor...

Zafrul Hasan, Mahedi Hasan, Arafat Islam Ashik, Md. Ali Newaj et al.

In the early establishment of HIV-1 infection, Tat protein plays an essential role in controlling other genes of HIV-1 (e.g., vif, vpr, vpu, nef, gag, pol and env), for viral pathogenesis, while maintaining its polymorphic nature. It is well documented that polymorphism of HIV-1 genome are created t...

Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.

BACKGROUND: β-thalassemia poses a considerable public health burden in Bangladesh, where a high carrier frequency underlies widespread disease risk. It is necessary to distinguish β-thalassemia trait (βTT) and iron deficiency anemia (IDA) to ensure genetic counseling and enable effective prevention ...

Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.

<div> Background β-thalassemia poses a considerable public health burden in Bangladesh, where a high carrier frequency underlies widespread disease risk. It is necessary to distinguish β-thalassemia trait (βTT) and iron deficiency anemia (IDA) to ensure genetic counseling and enable effective preven...

Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.

Discriminant formulas applied for the evaluation of the diagnosis of β-thalassemia trait (βTT) in the Bangladeshi population.

Rumana Mahtarin, Kasrina Azad, Rakib Bin Mahbub Talukder, Rynak Rahmat et al.

<div> Background β-thalassemia poses a considerable public health burden in Bangladesh, where a high carrier frequency underlies widespread disease risk. It is necessary to distinguish β-thalassemia trait (βTT) and iron deficiency anemia (IDA) to ensure genetic counseling and enable effective preven...

Mst. Noorjahan Begum, Suprovath Kumar Sarker, Md Tarikul Islam, Golam Sarower Bhuyan et al.

Congenital hypothyroidism (CH), characterized by insufficient thyroid hormone production at birth, is frequently associated with fatigue, particularly in cases with delayed diagnosis. This study employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to profile carnitine and acylcarnitine...

Afifa Parvin Shanta, Fatema-Tuz-Zohora, Rumana Mahtarin, Alexander D. MacKerell et al.

for the first time. MD simulations of the identified compounds indicated their potential to bind to the aldose reductase (AKR1B1) protein. Predicted binding affinities of the compounds based on the site identification the ligand competitive saturation (SILCS) technology was -15.04, -8.85, -9.83, -11...

Mst. Noorjahan Begum, Rumana Mahtarin, Md Tarikul Islam, Nusrat Jahan Antora et al.

Abstract Thyroid Peroxidase ( TPO ) is known to be the major gene involved in Congenital hypothyroid patients with thyroid dyshormonogenesis. This present study aimed to establish high-resolution melting (HRM) curve analysis as a supplementary mutation detection approach of Sanger sequencing targeti...

Rumana Mahtarin, Kasrina Azad, Mohabbat Hossain, Mst. Sharmin Aktar Mukta et al.

Abstract Thalassemia is a hereditary blood disorder with different severity spectrums. This study aimed to assess thalassemia screening rates between children of Bangladesh and selected camps of Forcibly Displaced Myanmar Nationals (FDMN) in Cox’s Bazar in Bangladesh and compare the hematological pa...