Wasif Ali Khan, Sean R. Galagan, Chai Shwai Prue, Jacob Khyang et al.
BACKGROUND: Pregnancy is a known risk factor for malaria which is associated with increased maternal and infant mortality and morbidity in areas of moderate-high malaria transmission intensity where Plasmodium falciparum predominates. The nature and impact of malaria, however, is not well understood...
Sabeena Ahmed, Sean R. Galagan, Heather M. Scobie, Jacob Khyang et al.
BACKGROUND: Malaria is endemic in 13 of 64 districts of Bangladesh, representing a population at risk of about 27 million people. The highest rates of malaria in Bangladesh occur in the Chittagong Hill Districts, and Plasmodium falciparum (predominately chloroquine resistant) is the most prevalent s...
Hannah E Atlas, Bakary Conteh, Md Taufiqul Islam, Khuzwayo C. Jere et al.
Abstract Background Shigella is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, a precursor to stunting and lifelong morbidity. Several promising Shigella vaccines are in development and field efficacy trials will require a consortium of potentia...
Kerry Shannon, Wasif Ali Khan, David A. Sack, Mohammad Shafiul Alam et al.
OBJECTIVES: An analysis of the risk factors and seasonal and spatial distribution of individuals with subclinical malaria in hypoendemic Bangladesh was performed. METHODS: From 2009 to 2012, active malaria surveillance without regard to symptoms was conducted on a random sample (n=3971) and pregnant...
Jie Liu, Paul F. Garcia Bardales, Kamrul Islam, Sheikh Jarju et al.
Abstract Background Quantitative polymerase chain reaction (qPCR) targeting ipaH has been proven to be highly efficient in detecting Shigella in clinical samples compared to culture-based methods, which underestimate Shigella burden by 2- to 3-fold. qPCR assays have also been developed for Shigella ...
Sean R. Galagan, Chai Shwai Prue, Jacob Khyang, Wasif Ali Khan et al.
Malaria is endemic in the Chittagong Hill Districts of southeastern Bangladesh. Previous epidemiological analyses identified the agricultural practice of jhum cultivation as a potential risk factor for malaria infection. We conducted qualitative interviews with jhum cultivators and surveillance work...
Bri’Anna Horne, Henry Badji, Md Taufiqur Rahman Bhuiyan, Lucero Romaina Cachique et al.
Abstract Background Shigella is a major cause of diarrhea in young children worldwide. Multiple vaccines targeting Shigella are in development, and phase 3 clinical trials are imminent to determine efficacy against shigellosis. Methods The Enterics for Global Health (EFGH) Shigella surveillance stud...
Erika Feutz, Prasanta K. Biswas, Latif Ndeketa, Billy Ogwel et al.
Abstract Background Rigorous data management systems and planning are essential to successful research projects, especially for large, multicountry consortium studies involving partnerships across multiple institutions. Here we describe the development and implementation of data management systems a...
Ryan Dodd, Alex O Awuor, Paul F. Garcia Bardales, Farhana Khanam et al.
Abstract Background Accurate estimation of diarrhea incidence from facility-based surveillance requires estimating the population at risk and accounting for case patients who do not seek care. The Enterics for Global Health (EFGH) Shigella surveillance study will characterize population denominators...
Mohammad Tahir Yousafzai, Jennifer Cornick, Pablo Peñataro Yori, M. Jahangir Hossain et al.
M A Yousafzai, Jennifer Cornick, Pablo Peñataro Yori, M Jahangir Hossain et al.
BACKGROUND: Shigella is a leading cause of dysentery and watery diarrhoea in low-income and middle-income countries (LMICs) with consequences beyond diarrhoea for children younger than 5 years, including environmental enteric dysfunction and linear growth impairment. We established the burden, serot...
Bakary Conteh, Sean R. Galagan, Henry Badji, Ousman Secka et al.
Abstract Globally, respiratory tract infections (RTI) are the main cause of morbidity, and in Low-middle-income countries (LMICs) RTI including pneumonia are a leading cause of morbidity and mortality in children <5 years. Diarrheal illness increases RTI risk in young children through micronutrie...
Donnie Mategula, Bakary Conteh, Christine J. McGrath, Erika L. Feutz et al.
Background Shigella is a leading cause of diarrheal illness in children in low- and middle-income countries, with evidence of contribution to prolonged diarrhoea, hospitalization, and impaired growth. Methods In this prospective cohort study, we analysed data from 8756 children aged 6–35 months with...
Anya Lewin, Naveed Ahmed, Doh Sanogo, Musa Jallow et al.
Olívia Lang Schultes, Aneeta Hotwani, Patricia B. Pavlinac, M Jahangir Hossain et al.
BACKGROUND: Shigella vaccine development is a critical priority due to high burden and long-term outcomes among children. Choosing a clinical efficacy endpoint for Shigella vaccine trials requires comparing existing diarrhea severity definitions among children with Shigella. METHODS: Six- to 35-mont...
Olívia Lang Schultes, Aneeta Hotwani, Patricia B. Pavlinac, M. Jahangir Hossain et al.
Abstract Background Shigella has high global burden and serious long-term outcomes among young children. Increasing antibiotic resistance makes Shigella vaccine development a critical priority. Choosing the optimal clinical efficacy endpoint for Shigella vaccine trials requires comparing existing di...