Karen L. Kotloff, James P. Nataro, William C. Blackwelder, Dilruba Nasrin et al.
Background Diarrhoeal diseases cause illness and death among children younger than 5 years in low-income countries. We designed the Global Enteric Multicenter Study (GEMS) to identify the aetiology and population-based burden of paediatric diarrhoeal disease in sub-Saharan Africa and south Asia. Met...
A. Grant, A Avenell, Marion Campbell, Andrew M. McDonald et al.
Background Elderly people who have a fracture are at high risk of another. Vitamin D and calcium supplements are often recommended for fracture prevention. We aimed to assess whether vitamin D3 and calcium, either alone or in combination, were effective in prevention of secondary fractures. Methods ...
Chen-Shan Chin, Jon M. Sorenson, Jason B. Harris, William P. Robins et al.
BACKGROUND: Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera in Haiti. METHODS: We used third-generation single-molecule real-time DNA sequencing to determine the ge...
Samba O. Sow, Khitam Muhsen, Dilruba Nasrin, William C. Blackwelder et al.
BACKGROUND: The importance of Cryptosporidium as a pediatric enteropathogen in developing countries is recognized. METHODS: Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-sever...
Karen L. Kotloff, Dilruba Nasrin, William C. Blackwelder, Yukun Wu et al.
BACKGROUND: Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income and middle-income countries. The Global Enteric Multicenter Study (GEMS) has described the incidence, aetiology, and sequelae of medically attended moderate-to-severe diarrhoe...
Myron M. Levine, Dilruba Nasrin, Sozinho Acácio, Quique Bassat et al.
BACKGROUND: The Global Enteric Multicenter Study (GEMS) was a 3-year case-control study that measured the burden, aetiology, and consequences of moderate-to-severe diarrhoea (MSD) in children aged 0-59 months. GEMS-1A, a 12-month follow-on study, comprised two parallel case-control studies, one asse...
Sandra Panchalingam, Martín Antonio, Anowar Hossain, Inácio Mandomando et al.
To understand the etiology of moderate-to-severe diarrhea among children in high mortality areas of sub-Saharan Africa and South Asia, we performed a comprehensive case/control study of children aged <5 years at 7 sites. Each site employed an identical case/control study design and each utilized a u...
V. Spike Peterson
Click to increase image sizeClick to decrease image size Acknowledgments I am grateful to Georgina Waylen for her generosity in sharing prepublication work with me; and to Drucilla Barker, Jen Cohen, Deb Figart, Ellen Mutari, Julie Nelson, Paulette Olsen and Ara Wilson for conference discussions reg...
Eike Steinig, Sebastián Duchêne, D. Ashley Robinson, Stefan Monecke et al.
The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh and India in 2004. In this study, we showed that the Bengal Bay clone emerged from a virulent progenitor circulating on the Indian subcontinent. Its subsequent ...
Adrian Leftwich
Click to increase image sizeClick to decrease image size Notes 1. Atul Kohli, ‘State, society and development’, in: Ira Katnelson & Helen V. Milner (eds), Political Science: The State of the Discipline (W. W. Norton & Co., 2002), p. 117. 2. Dani Rodrik, ‘Growth strategies’, in: Philippe Aghion & Ste...
Chun Yu Lok, Alison T. Merryweather‐Clarke, Vip Viprakasit, Yingyong Chinthammitr et al.
Hereditary hemochromatosis is an iron overload disorder that can lead to the impairment of multiple organs and is caused by mutations in one or more different genes. Type 1 hemochromatosis is the most common form of the disease and results from mutations in the HFE gene. Juvenile hemochromatosis (JH...
Philip W. Boyd, Carol Robinson, Graham Savidge, P.J.leB. Williams
Carol A. Gilchrist, James A. Cotton, Cecelia Burkey, Tuhinur Arju et al.
We studied the genetic diversity of Cryptosporidium hominis infections in slum-dwelling infants from Dhaka over a 2-year period. Cryptosporidium hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole-genome resequencing. Recombination...
David Taylor‐Robinson, Hywel C Williams, Anna Pearce, Catherine Law et al.
BACKGROUND: Atopic dermatitis (eczema) in childhood is socially patterned, with higher incidence in more advantaged populations. However, it is unclear what factors explain the social differences. OBJECTIVES: To identify early-life risk factors for eczema, and to explore how early-life risk factors ...
William P. Robins, Shah M. Faruque, John J. Mekalanos
The sequence of a protein determines its function by influencing its folding, structure, and activity. Similarly, the most conserved residues of orthologous and paralogous proteins likely define those most important. The detection of important or essential residues is not always apparent via sequenc...