Muhammad Jahangir Hossen, Woo Seok Yang, Daewon Kim, Adithan Aravinthan et al.
Abstract Thymoquinone (TQ) is a bioactive component of black seed ( Nigella sativa ) volatile oil and has been shown to have anti-oxidative, anti-inflammatory, and anti-cancer properties. In the present study, we explored the molecular mechanisms that underlie the anti-inflammatory effect of TQ and ...
Shi Hyoung Kim, Jae Gwang Park, Jongsung Lee, Woo Seok Yang et al.
Even though a lot of reports have suggested the anti-inflammatory activity of kaempferol (KF) in macrophages, little is known about its exact anti-inflammatory mode of action and its immunopharmacological target molecules. In this study, we explored anti-inflammatory activity of KF in LPS-treated ma...
Muhammad Jahangir Hossen, Kwang‐Soo Baek, Eunji Kim, Woo Seok Yang et al.
Ethnopharmacologic relevance Persicaria chinensis L. (Polygonaceae) [also synonym as Polygonum chimnense L.] has been used as Chinese traditional medicine to treat ulcer, eczema, stomach ache, and various inflammatory skin diseases. Due to no molecular pharmacological evidence of this anti-inflammat...
Muhammad Jahangir Hossen, Seung Cheol Kim, Young‐Jin Son, Kwang‐Soo Baek et al.
In traditional Chinese medicine, Persicaria chinensis L. has been prescribed to cure numerous inflammatory disorders. We previously analyzed the bioactivity of the methanol extract of this plant (Pc-ME) against LPS-induced NO and PGE2 in RAW264.7 macrophages and found that it prevented HCl/EtOH-indu...
Van Thai Ha, Heung Soo Beak, Eunji Kim, Kwang‐Soo Baek et al.
AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigat...
Woo Seok Yang, Zubair Ahmed Ratan, Gihyeon Kim, Yunmi Lee et al.
The Cordyceps species has been a good source of compounds with anticancer and anti-inflammatory activities. Recently, we reported a novel compound (4-isopropyl-2,6-bis(1-phenylethyl)phenol, KTH-13) with anticancer activity isolated from Cordyceps bassiana and created several derivatives to increase ...
Han Gyung Kim, Ji Hye Kim, Woo Seok Yang, Jae Gwang Park et al.
Abstract Recently, a SET domain containing 3 (SETD3) was identified as an actin histidine methyltransferase, functioning to control replication and pathogenesis in multiple mouse models for enterovirus infection as well as the regulation of smooth muscle contractility linked to primary dystocia. Her...
Yong-Bo Lee, Young-Hee Na, Suk-Bae Baek, Jae Min Lee et al.