Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan et al.
Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Arai...
Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan et al.
Exposure to arsenic has long been known to have neurologic consequences in adults, but to date there are no well-controlled studies in children. We report results of a cross-sectional investigation of intellectual function in 201 children 10 years of age whose parents participate in our ongoing pros...
Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan et al.
BACKGROUND: We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells. OBJECTIVES: We present results of a similar investigation of 301 randomly selected 6-year-olds ...
Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Pam Factor‐Litvak et al.
Recently, epidemiologic studies of developmental neurotoxicology have been challenged to increase focus on co-exposure to multiple toxicants. Earlier reports, including our own work in Bangladesh, have demonstrated independent associations between neurobehavioral function and exposure to both arseni...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Chronic exposure to arsenic is occurring throughout South and East Asia due to groundwater contamination of well water. Variability in susceptibility to arsenic toxicity may be related to nutritional status. Arsenic is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via one...
Khalid Khan, Gail A. Wasserman, Xinhua Liu, Ershad Ahmed et al.
Drinking water manganese (WMn) is a potential threat to children’s health due to its associations with a wide range of outcomes including cognitive, behavioral and neuropsychological effects. Although adverse effects of Mn on cognitive function of the children indicate possible impact on their acade...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Background Populations in South and East Asia and many other regions of the world are chronically exposed to arsenic-contaminated drinking water. To various degrees, ingested inorganic arsenic (InAs) is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via folate-dependent on...
Faruque Parvez, Gail A. Wasserman, Pam Factor‐Litvak, Xinhua Liu et al.
BACKGROUND: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children's intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. METHODS: We investigated the associations...
Khalid Khan, Pam Factor‐Litvak, Gail A. Wasserman, Xinhua Liu et al.
Background: Evidence of neurological, cognitive, and neuropsychological effects of manganese (Mn) exposure from drinking water (WMn) in children has generated widespread public health concern. At elevated exposures, Mn has been associated with increased levels of externalizing behaviors, including i...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
Background Studies in cell culture and animal models indicate that arsenic exposure induces modifications in DNA methylation, including genome-wide DNA hypomethylation. It is not known whether arsenic exposure influences genomic DNA methylation in human populations chronically exposed to arsenic-con...
Gail A. Wasserman, Xinhua Liu, Nancy J. LoIacono, Jennie Kline et al.
BACKGROUND: In recent studies in Bangladesh and elsewhere, exposure to arsenic (As) via drinking water is negatively associated with performance-related aspects of child intelligence (e.g., Perceptual Reasoning, Working Memory) after adjustment for social factors. Because findings are not easily gen...
Marni Hall, Mary V. Gamble, Vesna Slavkovich, Xinhua Liu et al.
BACKGROUND: In Bangladesh, tens of millions of people have been consuming waterborne arsenic for decades. The extent to which As is transported to the fetus during pregnancy has not been well characterized. OBJECTIVES: We therefore conducted a study of 101 pregnant women who gave birth in Matlab, Ba...
J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
BACKGROUND: An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown. OBJECTIVE: The objective of this study was to investigate the influence of prenat...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
BACKGROUND: Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility. OBJECTIVE: A...
Yana Chervona, Megan N. Hall, Adriana Arita, Fen Wu et al.
BACKGROUND: Exposure to arsenic (As) is associated with an increased risk of several cancers as well as cardiovascular disease, and childhood neuro-developmental deficits. Arsenic compounds are weakly mutagenic, alter gene expression and posttranslational histone modifications (PTHMs) in vitro. METH...