Priya Duggal, Xiaoti Guo, Rashidul Haque, Kristine M. Peterson et al.
Malnutrition substantially increases susceptibility to Entamoeba histolytica in children. Leptin is a hormone produced by adipocytes that inhibits food intake, influences the immune system, and is suppressed in malnourished children. Therefore we hypothesized that diminished leptin function may incr...
Rashidul Haque, Mamun Kabir, Zannatun Noor, S. M. Mazidur Rahman et al.
The noninvasive diagnosis of amebic liver abscess is challenging, as most patients at the time of diagnosis do not have a concurrent intestinal infection with Entamoeba histolytica. Fecal testing for E. histolytica parasite antigen or DNA is negative in most patients. A real-time PCR assay was evalu...
Kôji Watanabe, Carol A. Gilchrist, Md. Jashim Uddin, Stacey L. Burgess et al.
The disease severity of Entamoeba histolytica infection ranges from asymptomatic to life-threatening. Recent human and animal data implicate the gut microbiome as a modifier of E. histolytica virulence. Here we have explored the association of the microbiome with susceptibility to amebiasis in infan...
Tania A. Thomas, Dinesh Mondal, Zannatun Noor, Lei Liu et al.
OBJECTIVE: We sought to compare the tuberculin skin test (TST) to the QuantiFERON-TB Gold In-Tube assay (QFT-IT) and assess the effects of malnourishment and intestinal helminth infection on QFT-IT results. METHODS: In this population-based cross-sectional study from Dhaka, Bangladesh, we screened c...
Humaira Rashid, Biplob Hossain, Towfida Jahan Siddiqua, Mamun Kabir et al.
MicroRNAs (miRNAs) are a class of conserved endogenous, small non-coding RNA molecules with a length of 18-25 nucleotides that regulate gene expression by RNA interference processes, including mRNA chopping, mRNA deadenylation, and translation inhibition. miRNAs maintain the physiological functions ...
Md. Amran Gazi, Subhasish Das, Md. Abdullah Siddique, Md Ashraful Alam et al.
ABSTRACT Chronic exposure to infectious agents results in environmental enteric dysfunction—a significant contributor to childhood stunting. Low plasma tryptophan (TRP), increased kynurenine (KYN), and KYN–TRP (KT) ratio are associated with infections and chronic immune activation. We postulated tha...
Md Hamidul Islam, Zannatun Noor Prova, Md. Habibur Rahman Sobuz, Nusrat Jahan Nijum et al.
<h2>Abstract</h2> The rapid global expansion of e-waste poses significant environmental and health risks, making it crucial to find sustainable uses and mitigate its harmful effects. The significance of this research is to look into the impact of e-waste as a possible substitute for natural coarse a...
Parag Palit, Rina Das, Md. Ahshanul Haque, Md. Mehedi Hasan et al.
The prevalence of norovirus infections in different geographical locations and their attribution to childhood diarrhea is well established. However, there are no reports showing possible relationships of different norovirus genogroups with subsequent childhood malnutrition. In this study, we attempt...
Saiful Arefeen Sazed, Mohammad Golam Kibria, Md Fahad Zamil, Mohammad Hossain et al.
There are several methods for the diagnosis of coronavirus disease 2019 (COVID-19), and the choice of methods depends mostly on the resources and level of sensitivity required by the user and health care providers. Still, reverse transcription polymerase chain reaction (RT-PCR) has been chosen as th...
Zannatun Noor, Biplob Hossain, Nishad Tasnim Mithila, Amena Khatun et al.
Cryptosporidium spp. is a cause of diarrhea morbidity and mortality in children under 5 years of age. In addition, asymptomatic infections can have a negative impact on growth and development. In low- and middle-income countries where a greater number of infants may be malnourished, the results of t...
Zannatun Noor, Md. Mehedi Hasan, Md. Amran Gazi, Farzana Hossaini et al.
Malnourished children are susceptible to an increased risk of mortality owing to impaired immune functions. However, the underlying mechanism of altered immune functions and its interaction with malnutrition is poorly understood. This study investigates the immune function and evaluates the effect o...
Humaira Rashid, Towfida Jahan Siddiqua, Biplob Hossain, Abdullah Siddique et al.
Introduction: MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression. Changes in miRNA expression have been reported in a number of intestinal diseases, in both tissue samples and readily accessible specimens like stools. Pathogenic infections, diet, toxin...
Parag Palit, Md. Amran Gazi, Subhasish Das, Md. Mehedi Hasan et al.
Dysregulations in the mammalian target of rapamycin (mTOR) pathway are associated with several human anomalies. We aimed to elucidate possible implications for potential aberrations in the mTOR pathway with childhood malnutrition. We analyzed the activity of phospho-mTORC1 and the expressions of sev...
Guillaume Butler‐Laporte, Kathryn Auckland, Zannatun Noor, Mamun Kabir et al.
Abstract Hepatitis B virus (HBV) vaccine escape mutants (VEM) are increasingly described, threatening progress in control of this virus worldwide. Here we studied the relationship between host genetic variation, vaccine immunogenicity and viral sequences implicating VEM emergence. In a cohort of 1,0...
Jennifer Hendrick, Rubhana Raqib, Zannatun Noor, Shah M. Faruque et al.
Shigella is a Gram-negative, facultative intracellular, gastric acid-resistant bacterium of the Enterobacteriaceae family, which includes four serogroups: Shigella dysenteriae, Shigella sonnei, Shigella flexneri, and Shigella boydii. Globally, shigellosis is the most common cause of invasive bloody ...