Julia C. Cutts, Katherine O’Flaherty, Sophie Zaloumis, Elizabeth A. Ashley et al.
BACKGROUND: Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southeast Asia, where resistance has emerged, P. falciparum antibo...
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak et al.
Abstract The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducte...
Roberto Amato, Olivo Miotto, Charles J. Woodrow, Jacob Almagro‐Garcia et al.
Abstract Artemisinin resistant Plasmodium falciparum is advancing across Southeast Asia in a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Afr...