A. Huq, Rita R. Colwell, R Rahman, Afsar Ali et al.
Vibrio cholerae O1 in plankton samples collected from ponds and rivers between February 1987 and January 1990 in Matlab, Bangladesh, was detected by the fluorescent-monoclonal antibody (FA) technique. Samples were collected at sites which were monitored fortnightly (fixed sites) as well as at sites ...
G. Balakrish Nair, Firdausi Qadri, Jan Holmgren, Ann–Mari Svennerholm et al.
We determined the types of cholera toxin (CT) produced by a collection of 185 Vibrio cholerae O1 strains isolated in Bangladesh over the past 45 years. All of the El Tor strains of V. cholerae O1 isolated since 2001 produced CT of the classical biotype, while those isolated before 2001 produced CT o...
A.‐M. Svennerholm, Marianne Jertborn, I. e. Gothefors, Amr M. Karim et al.
Mucosal and systemic immune responses to a new oral cholera vaccine, consisting of the B subunit plus killed vibrios, were studied in Bangladeshi volunteers and compared with those to clinical cholera. A single peroral dose of vaccine induced a local IgA antitoxin response in intestinal-lavage fluid...
Munirul Alam, Marzia Sultana, G. Balakrish Nair, Abul K.M. Siddique et al.
Vibrio cholerae persists in aquatic environments predominantly in a nonculturable state. In this study coccoid, nonculturable V. cholerae O1 in biofilms maintained for 495 days in Mathbaria, Bangladesh, pond water became culturable upon animal passage. Culturability, biofilm formation, and the wbe, ...
Brian Schwartz, Jason B. Harris, Ashraful Islam Khan, Regina C. LaRocque et al.
We examined demographic, microbiologic, and clinical data from patients presenting during 1988, 1998, and 2004 flood-associated diarrheal epidemics at a diarrhea treatment hospital in Dhaka, Bangladesh. Compared with non-flood periods, individuals presenting during flood-associated epidemics were ol...
Jason B. Harris, Ashraful Islam Khan, Regina C. LaRocque, David J. Dorer et al.
Individuals with blood group O are more susceptible than other individuals to severe cholera, although the mechanism underlying this association is unknown. To assess the respective roles of both intrinsic host factors and adaptive immune responses that might influence susceptibility to infection wi...
R. Bradley Sack, Abdullah Siddique, Ira M. Longini, Azhar Nizam et al.
How Vibrio cholerae spreads around the world and what determines its seasonal peaks in endemic areas are not known. These features of cholera have been hypothesized to be primarily the result of environmental factors associated with aquatic habitats that can now be identified. Since 1997, fortnightl...
Shah M. Faruque, Nityananda Chowdhury, Muhammad Kamruzzaman, Michelle Dziejman et al.
To understand the evolutionary events and possible selection mechanisms involved in the emergence of pathogenic Vibrio cholerae, we analyzed diverse strains of V. cholerae isolated from environmental waters in Bangladesh by direct enrichment in the intestines of adult rabbits and by conventional lab...
Vanessa Ha, John L. Sievenpiper, Russell J. de Souza, Viranda H. Jayalath et al.
BACKGROUND: Evidence from controlled trials encourages the intake of dietary pulses (beans, chickpeas, lentils and peas) as a method of improving dyslipidemia, but heart health guidelines have stopped short of ascribing specific benefits to this type of intervention or have graded the beneficial evi...
Shah M. Faruque, David A. Sack, R. Bradley Sack, Rita R. Colwell et al.
The emergence of Vibrio cholerae O139 Bengal during 1992-1993 was associated with large epidemics of cholera in India and Bangladesh and, initially, with a total displacement of the existing V. cholerae O1 strains. However, the O1 strains reemerged in 1994 and initiated a series of disappearance and...
Qifang Bi, Eva Ferreras, Lorenzo Pezzoli, Dominique Legros et al.
BACKGROUND: Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges...
Mustafizur Rahman, Rasheda Sultana, Giasuddin Ahmed, Sharifun Nahar et al.
Approximately 20,000 stool specimens from patients with diarrhea visiting 1 urban and 1 rural hospital in Bangladesh during January 2001-May 2006 were tested for group A rotavirus antigen, and 4,712 (24.0%) were positive. G and P genotyping was performed on a subset of 10% of the positive samples (n...
Munirul Alam, Marzia Sultana, G. Balakrish Nair, R. Bradley Sack et al.
Toxigenic Vibrio cholerae, rarely isolated from the aquatic environment between cholera epidemics, can be detected in what is now understood to be a dormant stage, i.e., viable but nonculturable when standard bacteriological methods are used. In the research reported here, biofilms have proved to be...
ASG Faruque, AM Shamsir Ahmed, Tahmeed Ahmed, M Munirul Islam et al.
Recent data from the World Health Organization showed that about 60% of all deaths, occurring among children aged less than five years (under-five children) in developing countries, could be attributed to malnutrition. It has been estimated that nearly 50.6 million under-five children are malnourish...
Paul Farmer, Charles Patrick Almazor, Emily T. Bahnsen, Donna Barry et al.
Meeting Cholera's Challenge to Haiti and the World: A Joint Statement on Cholera Prevention and Care