Debashish Biswas, Raduan Hossin, Mahbubur Rahman, Kevin Bardosh et al.
INTRODUCTION Diarrheal disease is one of the most common causes of hospital admission globally. The barriers that influence guideline-adherent care at resource limited hospitals are poorly defined, especially during diarrheal disease outbreaks. The objective of this study was to characterize challen...
Annette Peters, Klaus Stark, Muntaser D. Musameh, Christopher P. Nelson et al.
Adverse levels of lipoproteins are highly heritable and constitute risk factors for cardiovascular outcomes. Hitherto, genome-wide association studies revealed 95 lipid-associated loci. However, due to the small effect sizes of these associations large sample numbers (>100 000 samples) were needed. ...
Jason R. Andrews, Daniel T. Leung, Shahnawaz Ahmed, Mohammed A. Malek et al.
BACKGROUND: To take advantage of emerging opportunities to reduce morbidity and mortality from diarrheal disease, we need to better understand the determinants of life-threatening severe dehydration (SD) in resource-poor settings. METHODOLOGY/FINDINGS: We analyzed records of patients admitted with a...
Alba Covelo-Paz, Emma Giovinazzo, Pascal A. Oesch, R. A. Meyer et al.
The H α nebular emission line is an optimal tracer for recent star formation in galaxies. With the advent of JWST , this line has recently become observable at z > 3 for the first time. We present a catalog of 1050 H α emitters at 3.7 < z < 6.7 in the GOODS fields obtained from a blind sear...
Stephanie C. Garbern, Tzu-Chun Chu, Phillip Yang, Monique Gainey et al.
OBJECTIVES: Few studies have evaluated determinants of multidrug-resistant (MDR) Vibrio cholerae O1 in older children and adults. This study aimed to characterize the prevalence of MDR V. cholerae O1 and associated risk factors among patients over five years of age in Bangladesh. METHODS: Stool cult...
L. А. Alexandrova, Farhana Haque, Patricia Hernández-Rodríguez, Ashton C Marrazzo et al.
BACKGROUND: A first step to combating antimicrobial resistance in enteric pathogens is to establish an objective assessment of antibiotic exposure. Our goal was to develop and evaluate a liquid chromatography-ion trap mass spectrometry (LC/MS) method to determine antibiotic exposure in patients with...
Stephanie C. Garbern, Eric J. Nelson, Sabiha Nasrin, Adama Mamby Keita et al.
Background: Diarrheal illness is a leading cause of antibiotic use for children in low- and middle-income countries. Determination of diarrhea etiology at the point-of-care without reliance on laboratory testing has the potential to reduce inappropriate antibiotic use. Methods: This prospective obse...
Eric J. Nelson, Jessica A. Grembi, Dennis L. Chao, Jason R. Andrews et al.
= 78/849), the odds that a rapid diagnostic test (RDT) or qPCR was positive was reduced by 89% (odds ratio [OR], 0.108; 95% confidence interval [CI], 0.002 to 0.872) and 87% (OR, 0.130; 95% CI, 0.022 to 0.649), respectively, when lytic bacteriophage were detected. The odds that an RDT or qPCR was po...
Eric J. Nelson, Jason R. Andrews, Stace Maples, Michèle Barry et al.
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Adam C. Levine, Meagan A. Barry, Monique Gainey, Sabiha Nasrin et al.
Diarrheal diseases lead to an estimated 1.3 million deaths each year, with the majority of those deaths occurring in patients over five years of age. As the severity of diarrheal disease can vary widely, accurately assessing dehydration status remains the most critical step in acute diarrhea managem...
Vasily Kokorev, Hakim Atek, John Chisholm, Ryan Endsley et al.
Abstract We report the discovery of two galaxy candidates at redshifts between 15.7 < z < 16.4 in James Webb Space Telescope (JWST) observations from the GLIMPSE survey. These robust sources were identified using a combination of Lyman break selection and photometric redshift estimates. The ul...
Erica Nelson, Daniela Reyes Saade, P. Gregg Greenough
BACKGROUND: The Rohingya refugee crisis in Bangladesh continues to outstrip humanitarian resources and undermine the health and security of over 900,000 people. Spatial, sector-specific information is required to better understand the needs of vulnerable populations, such as women and girls, and to ...
Robert D. Sheeler, Michael J. Ackerman, Elliott Richelson, Thomas K. Nelson et al.
Cindy Castillejos-Petalcorin, David De Padua, Rhea Molato, Nedelyn Magtibay‐Ramos et al.
This report forecasts growth in developing Asia of 7.1% in 2021 and 5.4% in 2022 in an uneven recovery caused by divergent growth paths. Its theme chapter explores sustainable agriculture. Growth forecasts are revised up for East Asia and Central Asia from the projections made in April, but down for...
Stephanie C. Garbern, Tzu-Chun Chu, Monique Gainey, Samika Kanekar et al.
BACKGROUND: Antimicrobial resistance (AMR) is a global public health threat and is increasingly prevalent among enteric pathogens in low- and middle-income countries (LMICs). However, the burden of multidrug-resistant organisms (MDROs) in older children, adults, and elderly patients with acute diarr...
Eric J. Nelson, Ashraful Islam Khan, Adama Mamby Keita, Ben J. Brintz et al.
Importance: Inappropriate use of antibiotics for diarrheal illness can result in adverse effects and increase in antimicrobial resistance. Objective: To determine whether the diarrheal etiology prediction (DEP) algorithm, which uses patient-specific and location-specific features to estimate the pro...
Saadiyah Bilal, Eric J. Nelson, Lars Meisner, Md Mahfuj Alam et al.
Diarrhea remains a leading cause of morbidity and mortality in patients worldwide. The objective of this study was to determine the relative inter-rater reliability and usability of standard and Mobile health (mHealth)-supported World Health Organization (WHO) algorithms for dehydration assessment i...
Ashton Creasy-Marrazzo, Morteza M. Saber, Manasi Kamat, Laura S. Bailey et al.
The antibiotic formulary is threatened by high rates of antimicrobial resistance (AMR) among enteropathogens. Enteric bacteria are exposed to anaerobic conditions within the gastrointestinal tract, yet little is known about how oxygen exposure influences AMR. The facultative anaerobe Vibrio cholerae...
Helena Treiber, Jenny E. Greene, John R. Weaver, Tim B. Miller et al.
Abstract JWST has revealed diverse new populations of high-redshift ( z ∼ 4–11) active galactic nuclei (AGNs) and extreme star-forming galaxies that challenge current photoionization models. In this paper, we use rest-frame UV emission-line diagnostics to identify AGN candidates and other exceptiona...
Adam C. Levine, Monique Gainey, Kexin Qu, Sabiha Nasrin et al.
BackgroundDespite the importance of accurate and rapid assessment of hydration status in patients with acute diarrhoea, no validated tools exist to help clinicians assess dehydration severity in older children and adults. The aim of this study is to validate a clinical decision support tool (CDST) a...