Gwendolyn Osborne, Fen Wu, Liying Yang, Dervla Kelly et al.
Our objective was to investigate the relationship between the gut microbiota and anthropometric measurements among 248 participants from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Our cohort represents a unique population that allows for the investigation of the gut micr...
Dayana A. Delgado, Chenan Zhang, Lin Chen, Jianjun Gao et al.
Background Leucocyte telomere length (TL) is a potential biomarker of ageing and risk for age-related disease. Leucocyte TL is heritable and shows substantial differences by race/ethnicity. Recent genome-wide association studies (GWAS) report ~10 loci harbouring SNPs associated with leucocyte TL, bu...
Emily Vogtmann, Jun Chen, Muhammad G. Kibriya, Amnon Amir et al.
BACKGROUND: A number of cohort studies have collected Scope mouthwash samples by mail, which are being used for microbiota measurements. We evaluated the stability of Scope mouthwash samples at ambient temperature and determined the comparability of Scope mouthwash with saliva collection using the O...
Fen Wu, Liying Yang, Muhammad Tariqul Islam, Farzana Jasmine et al.
BACKGROUND: Emerging data suggest that inorganic arsenic exposure and gut microbiome are associated with the risk of cardiovascular disease. The gut microbiome may modify disease risk associated with arsenic exposure. Our aim was to examine the inter-relationships between arsenic exposure, the gut m...
Maria Argos, Mahfuzar Rahman, Faruque Parvez, James J. Dignam et al.
BACKGROUND: Epidemiologic research suggests that increased cancer risk due to chronic arsenic exposure persists for several decades even after the exposure has terminated. Observational studies suggest that antioxidants exert a protective effect on arsenical skin lesions and cancers among those chro...
Muhammad G. Kibriya, Liaquat Ali, Nani G Banik, Abul Kalam Azad Khan
The cost-effectiveness of home monitoring of blood glucose (HMBG) in Type-2 diabetes in a developing country was evaluated. A total of 64 uncomplicated Type-2 diabetic individuals of higher middle class to rich socio-economic status were studied. Thirty-two were allocated to conventional monthly hos...
Fen Wu, Farzana Jasmine, Muhammad G. Kibriya, Mengling Liu et al.
Background: Epidemiologic data on genetic susceptibility to cardiovascular effects of arsenic exposure from drinking water are limited.Objective: We investigated whether the association between well-water arsenic and cardiovascular disease (CVD) differed by 170 single nucleotide polymorphisms (SNPs)...
Dayana A. Delgado, Chenan Zhang, Kevin J. Gleason, Kathryn Demanelis et al.
Leukocyte telomere length (LTL) is a heritable trait with two potential sources of heritability (h2): inherited variation in non-telomeric regions (e.g., SNPs that influence telomere maintenance) and variability in the lengths of telomeres in gametes that produce offspring zygotes (i.e., “direct” in...
Yu-Hsuan Shih, Caitlin G. Howe, Molly Scannell Bryan, Hasan Shahriar et al.
Background: Hypertension in later life, a significant risk factor for cardiovascular disease, has been linked to elevated blood pressure in early life. Exposure to metals may influence childhood blood pressure; however, previous research is limited and has mainly focused on evaluating the toxicity o...
Megan M. Niedzwiecki, Xinhua Liu, Huiping Zhu, Megan N. Hall et al.
Background Inorganic arsenic (As) is methylated via one carbon metabolism (OCM) to mono- and dimethylated arsenicals (MMA and DMA), facilitating urinary excretion. Hyperhomocysteinemia (HHcys), a marker of impaired OCM, is a risk factor for As-induced skin lesions, but the influences of single nucle...
Farzana Jasmine, Ronald Rahaman, Shantanu Roy, Maruf Raza et al.
BACKGROUND: Formalin-fixed, paraffin-embedded (FFPE) samples are a highly desirable resource for epigenetic studies, but there is no suitable platform to assay genome-wide methylation in these widely available resources. Recently, Thirlwell et al. (2010) have reported a modified ligation-based DNA r...
Chenan Zhang, Muhammad G. Kibriya, Farzana Jasmine, Shantanu Roy et al.
Background: Chronic arsenic exposure is associated with increased risk for arsenical skin lesions, cancer, and other adverse health outcomes. One potential mechanism of arsenic toxicity is telomere dysfunction. However, prior epidemiological studies of arsenic exposure, telomere length (TL), and ski...
Brandon L. Pierce, Tong Lin, Samantha G. Dean, Maria Argos et al.
Inorganic arsenic (iAs) is a carcinogen, and exposure to iAs via food and water is a global public health problem. iAs-contaminated drinking water alone affects >100 million people worldwide, including ~50 million in Bangladesh. Once absorbed into the blood stream, most iAs is converted to mono-meth...
Fen Wu, Farzana Jasmine, Muhammad G. Kibriya, Mengling Liu et al.
Epidemiologic studies that evaluated genetic susceptibility to the effects of arsenic exposure from drinking water on subclinical atherosclerosis are limited. We conducted a cross-sectional study of 1,078 participants randomly selected from the Health Effects of Arsenic Longitudinal Study in Banglad...
Maria Argos, Tong Lin, Brandon L. Pierce, Muhammad Rakibuz‐Zaman et al.
BACKGROUND: The high prevalence of tobacco use in some developing nations, including Bangladesh, poses several public health challenges for these populations. Smoking behaviour is determined by genetic and environmental factors; however, the genetic determinants of smoking behaviour have not been pr...