Josh Hanson, Sue J. Lee, Sanjib Mohanty, Maryam Faiz et al.
BACKGROUND: Most adults dying from falciparum malaria will die within 48 hours of their hospitalisation. An essential component of early supportive care is the rapid identification of patients at greatest risk. In resource-poor settings, where most patients with falciparum malaria are managed, decis...
Richard J. Maude, Katherine Plewes, Muneeb Faiz, Josh Hanson et al.
Several antimalarials can cause significant prolongation of the electrocardiograph QT interval, which can be associated with an increased risk of potentially lethal ventricular arrhythmias. High doses of artemether and artemotil have been associated with QT prolongation in dogs, raising the possibil...
Josh Hanson, Amir Hossain, Prakaykaew Charunwatthana, Mahtab Uddin Hassan et al.
Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established. Clinical and biochemical data were prospectively collected from 171 consecutive Bangladeshi adults with severe malaria. On admission, 57% of...
Atthanee Jeeyapant, Hugh W. F. Kingston, Katherine Plewes, Richard J. Maude et al.
BACKGROUND: Clinical trials in severe falciparum malaria require a large sample size to detect clinically meaningful differences in mortality. This means few interventions can be evaluated at any time. Using a validated surrogate endpoint for mortality would provide a useful alternative allowing a s...
Josh Hanson, Amir Hossain, Prakaykaew Charunwatthana, Mahtab Uddin Hassan et al.
Although hyponatremia occurs in most patients with severe malaria, its pathogenesis, prognostic significance, and optimal management have not been established. Clinical and biochemical data were prospectively collected from 171 consecutive Bangladeshi adults with severe malaria. On admission, 57% of...
Haruhiko Ishioka, Aniruddha Ghose, Prakaykaew Charunwatthana, Richard J. Maude et al.
BACKGROUND: Hyperlactatemia is a strong predictor of mortality in severe falciparum malaria. Sequestered parasitized erythrocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis. METHODS: In a cohort of patients with falcipa...
Richard J. Maude, Katherine Plewes, Muneeb Faiz, Josh Hanson et al.
Several antimalarials can cause significant prolongation of the electrocardiograph QT interval, which can be associated with an increased risk of potentially lethal ventricular arrhythmias. High doses of artemether and artemotil have been associated with QT prolongation in dogs, raising the possibil...
Josh Hanson, Md Mahtab Uddin Hasan, A. A. N. M. Royakkers, Shamsul Alam et al.
BACKGROUND: Acute renal failure is a common complication of severe malaria in adults, and without renal replacement therapy (RRT), it carries a poor prognosis. Even when RRT is available, delaying its initiation may increase mortality. Earlier identification of patients who will need RRT may improve...
Haruhiko Ishioka, Katherine Plewes, Rajyabardhan Pattnaik, Hugh Kingston et al.
BACKGROUND: Liberal fluid resuscitation has proved harmful in adults with severe malaria, but the level of restriction has not been defined. METHODS: In a prospective observational study in adults with severe falciparum malaria, restrictive fluid management was provided at the discretion of the trea...
Michael Herdman, Natthida Sriboonvorakul, Stije J. Leopold, Sam Douthwaite et al.
INTRODUCTION: Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. METHODS: In this prospective study, we characterised organic acids in adults with s...
Josh Hanson, Sophia WK Lam, Sanjib Mohanty, Shamshul Alam et al.
BACKGROUND: To optimize the fluid status of adult patients with severe malaria, World Health Organization (WHO) guidelines recommend the insertion of a central venous catheter (CVC) and a target central venous pressure (CVP) of 0-5 cmH2O. However there are few data from clinical trials to support th...
Richard J. Maude, Abdullah Abu Sayeed, Nicholas A. V. Beare, Prakaykaew Charunwatthana et al.
A specific retinopathy has been described in African children with cerebral malaria, but in adults this has not been extensively studied. It has great potential as a diagnostic and prognostic tool and pathogenetic marker. Since the structure and function of the retinal vasculature greatly resembles ...
Richard J. Maude, Md Gofranul Hoque, Md Mahtab Uddin Hasan, Md. Abu Sayeed et al.
Fariha Fairouz, Wirongrong Chierakul, Chayasin Mansanguan, Hisham Ahmed Imad et al.
With an alarmingly high case fatality rate (CFR) of 0.56% in 2024, marking the consecutive year to report its devastating outbreak on record in 2023 with 1,705 fatalities, dengue fever presents a major public health challenge in Bangladesh, with seasonal outbreaks causing morbidity, mortality, and s...
Haruhiko Ishioka, Aniruddha Ghose, Hugh Kingston, Katherine Plewes et al.
Abstract Background Pulmonary oedema is a feared and difficult to predict complication of severe malaria that can emerge after start of antimalarial treatment. Proinflammatory mediators are thought to play a central role in its pathogenesis. Methods An exploratory study was conducted to evaluate the...