Julia C. Cutts, Katherine O’Flaherty, Sophie Zaloumis, Elizabeth A. Ashley et al.
BACKGROUND: Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southeast Asia, where resistance has emerged, P. falciparum antibo...
Roberto Amato, Olivo Miotto, Charles J. Woodrow, Jacob Almagro‐Garcia et al.
Abstract Artemisinin resistant Plasmodium falciparum is advancing across Southeast Asia in a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Afr...