Neeraj Narula, Emily C L Wong, Mahshid Dehghan, Andrew Mente et al.
OBJECTIVE: To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). DESIGN: Prospective cohort study. SETTING: 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle Eas...
Patricio López‐Jaramillo, Diego Gómez-Arbeláez, Daniel Martínez-Bello, Marc Evans M. Abat et al.
BackgroundThe triglyceride glucose (TyG) index is an easily accessible surrogate marker of insulin resistance, an important pathway in the development of type 2 diabetes and cardiovascular diseases. However, the association of the TyG index with cardiovascular diseases and mortality has mainly been ...
Marjan Walli-Attaei, Philip Joseph, Annika Rosengren, Clara K Chow et al.
BACKGROUND Some studies, mainly from high-income countries (HICs), report that women receive less care (investigations and treatments) for cardiovascular disease than do men and might have a higher risk of death. However, very few studies systematically report risk factors, use of primary or seconda...
Andrew Mente, Martin O’Donnell, Sumathy Rangarajan, Matthew McQueen et al.
BACKGROUND WHO recommends that populations consume less than 2 g/day sodium as a preventive measure against cardiovascular disease, but this target has not been achieved in any country. This recommendation is primarily based on individual-level data from short-term trials of blood pressure (BP) with...
P.J. Devereaux, Maura Marcucci, Thomas Painter, David Conen et al.
BACKGROUND: Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. METHODS: We conducted a trial involving patients undergoing noncardiac surgery. Patients were randomly assigned to receive trane...
Abhinav Goyal, Salim Yusuf
Ischaemic heart disease and stroke are among the most common causes of death and disability in the world. The Indian subcontinent (including India, Pakistan, Bangladesh, Sri Lanka, and Nepal) has among the highest rates of cardiovascular disease (CVD) globally. Previous reports have highlighted the ...
Darryl P. Leong, Koon Teo, Sumathy Rangarajan, V. Raman Kutty et al.
Abstract Background The measurement of handgrip strength (HGS) has prognostic value with respect to all‐cause mortality, cardiovascular mortality and cardiovascular disease, and is an important part of the evaluation of frailty. Published reference ranges for HGS are mostly derived from Caucasian po...
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Matthew McQueen et al.
Background The relation between dietary nutrients and cardiovascular disease risk markers in many regions worldwide is unknown. In this study, we investigated the effect of dietary nutrients on blood lipids and blood pressure, two of the most important risk factors for cardiovascular disease, in low...
Selina Rajan, Martin McKee, Sumathy Rangarajan, Shrikant I. Bangdiwala et al.
Importance: Depression is associated with incidence of and premature death from cardiovascular disease (CVD) and cancer in high-income countries, but it is not known whether this is true in low- and middle-income countries and in urban areas, where most people with depression now live. Objective: To...
Adrianna Murphy, Benjamin Palafox, Marjan Walli-Attaei, Timothy Powell‐Jackson et al.
Background: Non-communicable diseases (NCDs) are the leading cause of death globally. In 2014, the United Nations committed to reducing premature mortality from NCDs, including by reducing the burden of healthcare costs. Since 2014, the Prospective Urban and Rural Epidemiology (PURE) Study has been ...
David J.A. Jenkins, Mahshid Dehghan, Andrew Mente, Shrikant I. Bangdiwala et al.
BACKGROUND: Most data regarding the association between the glycemic index and cardiovascular disease come from high-income Western populations, with little information from non-Western countries with low or middle incomes. To fill this gap, data are needed from a large, geographically diverse popul...
Marjan Walli-Attaei, Rasha Khatib, Martin McKee, Scott A. Lear et al.
BACKGROUND: Hypertension is considered the most important risk factor for cardiovascular diseases, but its control is poor worldwide. We aimed to assess the availability and affordability of blood pressure-lowering medicines, and the association with use of these medicines and blood pressure control...
Gilles R. Dagenais, Hertzel C. Gerstein, Xiaohe Zhang, Matthew McQueen et al.
OBJECTIVE: The goal of this study was to assess whether diabetes prevalence varies by countries at different economic levels and whether this can be explained by known risk factors. RESEARCH DESIGN AND METHODS: The prevalence of diabetes, defined as self-reported or fasting glycemia ≥7 mmol/L, was d...
MyLinh Duong, Shofiqul Islam, Sumathy Rangarajan, Darryl P. Leong et al.
BACKGROUND: ) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary across populations is unknown. METHODS: % <-2 SDs [ie, clinically abnormal range]). Follow-up was done every 3 years to collect information on ...
Clara K Chow, Chinthanie Ramasundarahettige, Weihong Hu, Khalid F. AlHabib et al.
BACKGROUND Data are scarce on the availability and affordability of essential medicines for diabetes. Our aim was to examine the availability and affordability of metformin, sulfonylureas, and insulin across multiple regions of the world and explore the effect of these on medicine use. METHODS In th...