Brandon L. Pierce, Muhammad G. Kibriya, Tong Lin, Farzana Jasmine et al.
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer. There is inter-individual variation in arsenic metabolism efficiency and susceptibility to arsenic toxicity; however, the basis of this variation ...
Yu Chen, Fen Wu, Mengling Liu, Faruque Parvez et al.
BACKGROUND: Few prospective studies have evaluated the influence of arsenic methylation capacity on cardiovascular disease (CVD) risk. OBJECTIVE: We evaluated the association of arsenic exposure from drinking water and arsenic methylation capacity with CVD risk. METHOD: We conducted a case-cohort st...
Marni Hall, Mary V. Gamble, Vesna Slavkovich, Xinhua Liu et al.
BACKGROUND: In Bangladesh, tens of millions of people have been consuming waterborne arsenic for decades. The extent to which As is transported to the fetus during pregnancy has not been well characterized. OBJECTIVES: We therefore conducted a study of 101 pregnant women who gave birth in Matlab, Ba...
J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Vesna Ilievski et al.
BACKGROUND: An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown. OBJECTIVE: The objective of this study was to investigate the influence of prenat...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
BACKGROUND: Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility. OBJECTIVE: A...
Julia E. Heck, Mary V. Gamble, Yu Chen, Joseph H. Graziano et al.
Background Inorganic arsenic (InAs) is metabolized to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), and this methylation facilitates urinary arsenic excretion. Previous studies suggest that persons with more complete methylation, characterized as greater proportions of DMA and lesser ...
Faruque Parvez, Yu Chen, Mahbub Yunus, Christopher O. Olopade et al.
RATIONALE: Exposure to arsenic through drinking water has been linked to respiratory symptoms, obstructive lung diseases, and mortality from respiratory diseases. Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic. OBJECTIVES: To ...
F. Parvez, Yu Chen, Paul W. Brandt‐Rauf, Vesna Slavkovich et al.
BACKGROUND AND AIMS: A prospective cohort study was conducted to evaluate the effect of arsenic (As) exposure from drinking water on respiratory symptoms using data from the Health Effects of Arsenic Exposure Longitudinal Study (HEALS), a large prospective cohort study established in Ariahazar, Bang...
Faruque Parvez, Yu Chen, Paul W. Brandt‐Rauf, Alfred Bernard et al.
BACKGROUND: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bia...
Yu Chen, Alexander van Geen, Joseph H. Graziano, Alexander Pfaff et al.
BACKGROUND: There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh. OBJECTIVE: We evaluated the effectiveness of a multifaceted mitigation program to reduce As exposure among 11,746 individuals in a prospective cohort study ini...
Mary V. Gamble, Habibul Ahsan, Xinhua Liu, Pam Factor‐Litvak et al.
Background Indian Asian men residing in the United Kingdom have a higher prevalence of hyperhomocysteinemia than do their European counterparts. This has been largely attributed to dietary deficiencies in cobalamin associated with vegetarianism among these Indian Asians. Objective We aimed to ascert...
Yu Chen, Habibul Ahsan, Vesna Slavkovich, Gretchen Loeffler Peltier et al.
BACKGROUND: The long-term effects of arsenic exposure from drinking water at levels < 300 microg/L and the risk of diabetes mellitus remains a controversial topic. METHOD: We conducted a population-based cross-sectional study using baseline data from 11,319 participants in the Health Effects of Arse...
Yu Chen, Fen Wu, Joseph H. Graziano, Faruque Parvez et al.
We conducted a cross-sectional study to evaluate the interrelationships between past arsenic exposure, biomarkers specific for susceptibility to arsenic exposure, and carotid intima-media thickness (cIMT) in 959 subjects from the Health Effects of Arsenic Longitudinal Study in Bangladesh. We measure...
Megan N. Hall, Xinhua Liu, Vesna Slavkovich, Vesna Ilievski et al.
BACKGROUND: Approximately 35 million people in Bangladesh are chronically exposed to inorganic arsenic (InAs) in drinking water. Methylation of InAs to monomethylarsonic (MMA) and dimethylarsinic acids (DMA) relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic (uAs) elimi...
J. Richard Pilsner, Megan N. Hall, Xinhua Liu, Habibul Ahsan et al.
BACKGROUND: Global hypomethylation of DNA is thought to constitute an early event in some cancers and occurs in response to arsenic (As) exposure and/or selenium (Se) deficiency in both in vitro and animal models. In addition, antagonism between As and Se, whereby each reduces toxicity of the other,...