Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Anne Jackson et al.
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 ...
Daniel P. Donnelly, Catherine M. Rawlins, Caroline J. DeHart, Luca Fornelli et al.
One gene can give rise to many functionally distinct proteoforms, each of which has a characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins and proteoforms. Here members of the Consortium for Top-Down Proteomics provide a decision tree that guides research...
Ying Bai, Yuan Zhang, Bing Han, Li Yang et al.
Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, we show that the circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge...
Md Atiqul Haque, Yihui Wang, Zhiqiang Shen, Xiaohui Li et al.
Mycotoxins are secondary metabolites produced mainly by fungi belonging to the genera Aspergillus, Fusarium, Penicillium, Claviceps, and Alternaria that contaminate basic food products throughout the world, whether developing countries becoming predominantly affected. Currently, more than 500 mycoto...
Norihiro Kato, CARDIo GRAMplusCD, LifeLines Cohort Study, Marie Loh et al.
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). ...
Quan Zhang, Tao Jin, Jianguo Cai, Liang Xu et al.
Gait and waist motions always contain massive personnel information and it is feasible to extract these data via wearable electronics for identification and healthcare based on the Internet of Things (IoT). There also remains a demand to develop a cost-effective human-machine interface to enhance th...
Quangang Zhu, Zhongjian Chen, Pijush Paul, Yi Lü et al.
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeut...
CARDIoGRAMplusC4D, Joanna M. M. Howson, EPIC-CVD, Wei Zhao et al.
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may...
Saisai Li, Yuanzhi Jiang, Jian Xu, Di Wang et al.
α-FA 1-x Cs x PbI 3 is a promising absorbent material for efficient and stable perovskite solar cells (PSCs) 1,2 . However, the most efficient α-FA 1-x Cs x PbI 3 PSCs require the inclusion of the additive methylammonium chloride 3,4 , which generates volatile organic residues (methylammonium) that ...
Cindy Q. Tang, Tetsuya Matsui, Haruka Ohashi, Yi-Fei Dong et al.
Today East Asia harbors many "relict" plant species whose ranges were much larger during the Paleogene-Neogene and earlier. The ecological and climatic conditions suitable for these relict species have not been identified. Here, we map the abundance and distribution patterns of relict species, showi...
Wa Gao, Li Shi, Huichao He, Xiaoning Li et al.
Abstract Artificial photosynthesis, light-driving CO 2 conversion into hydrocarbon fuels, is a promising strategy to synchronously overcome global warming and energy-supply issues. The quaternary AgInP 2 S 6 atomic layer with the thickness of ~ 0.70 nm were successfully synthesized through facile ul...
Ziqian Xue, Yinle Li, Yawei Zhang, Wei Geng et al.
Abstract Exploring effective electrocatalysts for oxygen evolution reaction (OER) is a crucial requirement of many energy storage and conversion systems, involving fuel cells, water splitting, and metal–air batteries. Herein, a heterogeneity metal‐organic framework (MOF) is prepared by the assemblin...
Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung‐Jin Lee et al.
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D...
Xiang Wan, Mei Qing Qi, Tian Yi Chen, Tie Jun Cui
Digital phase shifters have been applied in traditional phased array antennas to realize beam steering. However, the phase shifter deals with the phase of the induced current; hence, it has to be in the path of each element of the antenna array, making the phased array antennas very expensive. Metam...
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Matthew McQueen et al.
Background The relation between dietary nutrients and cardiovascular disease risk markers in many regions worldwide is unknown. In this study, we investigated the effect of dietary nutrients on blood lipids and blood pressure, two of the most important risk factors for cardiovascular disease, in low...