Shiaw‐Lin Wu, Álvaro A. Figueroa, Barry L. Karger
We have studied the conformational behavior of alpha-lactalbumin (alpha-LACT) in hydrophobic interaction chromatography (HIC). Retention characterization in terms of Z (slope of plot of ln k' vs. ln phi B, where k' is the capacity factor and phi B is the volume fraction of mobile phase B) has been e...
Álvaro A. Figueroa, Claudio Corradini, Binyamin Feibush, Barry L. Karger
High-performance separations of proteins, based on immobilized-metal affinity chromatography (HPIMAC), are described. The stationary phase consisted of iminodiacetic acid (IDA) chelate groups, bonded to small particle, wide pore silica gel by means of a polyether hydrophilic leash. After loading the...
Olga Vera, Carlos Rodríguez‐Antolín, Ana Salgado-Figueroa, Patrycja Michalska et al.
Adjuvant chemotherapy for solid tumors based on platinum‐derived compounds such as cisplatin is the treatment of choice in most cases. Cisplatin triggers signaling pathways that lead to cell death, but it also induces changes in tumor cells that modify the therapeutic response, thereby leading to ci...